Myriad Genetics’ Post

About a month ago, Martha Kaiser shared a post in support of Skin Cancer Awareness Month. Her post appeared in my feed because we "linked" up after My Faulty Gene memorialized her story and the story of two of her children and their CDKN2A (p16INK4a) gene mutation for our #FamilyGeneShare video project. While CDKN2A is not a gene we hear much about, most of us are familiar with other gene mutations which put individuals at risk of melanoma. Did you know that the CDKN2A (p16INK4A) mutation is not only associated with a HIGH RISK of melanoma, it is also associated with a HIGH RISK of pancreatic cancer? Although I'd spent hours with Martha and her family during their film shoot, I never knew a key fact about Martha's genetic testing. As she relates in her post, only BRCA testing was originally ordered for Martha--probably because of her mother's breast cancer history as well as her own melanoma history. Martha shared that after her test was ordered, Myriad Genetics offered extended panel testing rather than the limited test originally ordered by her gynecologist. Had the multi-gene panel testing not been offered and used, Martha would not have known about her high risk of both melanoma and pancreatic cancer. I have shared numerous stories over the past several years about the benefits of multi-gene testing. And in our next series of videos we are currently scheduling for shooting this Fall, we will be including a couple of particularly compelling stories about the importance of multi-gene testing. While it is wonderful that providers other than genetic counselors and oncologists are ordering germline genetic testing--resulting in many mutations being identified--they can't be expected to be experts in knowing the best tests to order. So in addition to sharing Martha's family's important video to educate about a lesser-known gene mutation that can lead to deadly cancers, this post is also a reminder about the importance of utilizing genetic counselors in ordering tests. Referrals to genetic counselors are easy to make--and just might save a life! Here's the link to Martha, Erin and Nathan's video: https://lnkd.in/gg5-dEP8 #melanoma #pancreaticcancer #CDKN2A #melanomapancreaticcancersyndrome #hereditarycancer #knowyourrisk #familyhealthhistory #genetictesting #genetictestingsaveslives #geneticcounseling #geneticcounselor National Society of Genetic Counselors ConnectMyVariant.org CGA IGC

Kathy’s story is familiar. So many, given the chance to know their risk, decline. I have learned that fear and differential risk tolerance impacts a person’s decision to test for hereditary cancer risk. In Kathy’s case, testing caught ovarian cancer early, which is the entire goal. Knowledge is the best choice. #genetictesting #knowyourrisk #geneticcounseling #familyhealthhistory #brca #breastcancer #ovariancancer #pancreaticcancer #prostatecancer #hereditarycancer #cancersurvivor #previvor #genetictestingsaveslives #ConnectMyVariant

🔬 Stanford Medicine Study Unveils Gaps in Cancer Genetic Testing 🧬 A recent Stanford Medicine study highlights the increasing importance of germline testing in managing and detecting cancers caused by inherited mutations, which account for 5-10% of all cases. This testing helps identify these mutations, enabling early detection and selecting the most suitable medications or surgical treatment for each patient. Despite this, only 6.8% of more than a million cancer patients underwent this crucial genetic testing within two years of diagnosis. A contributing factor to these low rates is the lack of genetic counselling to patients regarding their cancer risk after testing. To address this gap, CircleDNA’s Premium DNA Test not only offers germline testing for cancer risk screening, but also provides a complimentary consultation with a certified genetic counsellor. This additional support enhances the overall understanding of individuals seeking insights into their genetic predispositions. For further insights, explore the full article here: https://lnkd.in/gexvmxpc If you are interested in understanding your genetic predispositions, email us at [email protected] with the subject ‘Cancer Risk Screening.’ #CircleDNA #CancerResearch #GeneticTesting #PreventiveHealth 💙

We are thrilled to spotlight customers like Marianne Vivien, CGC, and the team at Overlake Medical Center & Clinics' High-Risk Cancer Surveillance Clinic, who were featured on their local NBC news station for investing in expanding access to genetic testing in their community. Overlake uses CancerIQ's easy to complete risk-assessment questionnaire to proactively identify individuals at an elevated risk for hereditary cancer. With early onset cancers on the rise, it's more important than ever that cancer genetic providers create novel opportunities to invite more patients outside the four walls of the hospital to this life-saving tool ahead of a diagnosis, or to detect cancer at an early, treatable stage. As Marianne notes in her interview, "Genetic testing is for anybody." We’re proud to help their team scale these services with automated test ordering, patient education, and so much more. Watch Marianne's segment below: https://lnkd.in/emmVbmDf #precisionprevention #aheadofcancer #genechat

From today all people with Jewish ancestry will be able to get BRCA testing. This is the first community wide genetic testing programme and is a huge step forward in enabling more people to know their cancer risk and take measures to prevent cancer! We all have BRCA1 and BRCA2 genes. They are tumour suppressor genes and they play a role in protecting us from cancer. If there is a significant change (called an alteration or mutation) in either of the BRCA1 or BRCA2 genes, they may lose the ability to protect us from developing breast; ovarian; pancreatic and prostate cancers. People with Jewish ancestry are estimated to be six times more likely to have an altered BRCA gene. Current testing shows that 1 in 40 Jewish people have an altered BRCA gene. If someone finds out they are at an increased risk of certain cancers due to an altered BRCA gene they will be able to take measures to reduce this risk. They will be offered risk-reducing surgery (for breast and ovarian cancer) or be closely monitored so that any cancer can be found as early as possible, when it is most treatable. Opening up BRCA testing to anyone of Jewish ancestry will enable more people to know their cancer risk and take measures to reduce it, saving lives! This is a very proud day for Team Eve, who have supported Prof Ranjit Manchanda and his research (since his PhD onwards) in expanding genetic testing that has led to this news. A HUGE thank you to everyone who has supported us over the years and helped make this happen! You can find out more about how you can get tested on https://jewishbrca.org/ We have lots of information on BRCA and genetic testing on our website too and our Ask Eve nurses are always here for free information and support on [email protected] or 0808 802 0019. #BRCA #BRCA1 #BRCA2 #GeneticTesting #EveAppeal #TheEveAppeal #AskEve

Snippet 12 Breast cancer is a complex and heterogeneous disease characterized by the uncontrolled growth of abnormal cells in the breast tissue. While the majority of breast cancers are sporadic and not directly linked to inherited genetic mutations, a small percentage of cases are associated with hereditary factors. Hereditary testing, specifically genetic testing for mutations in certain genes, can provide valuable information about an individual's risk for developing breast cancer. Hereditary Factors in Breast Cancer: BRCA1 and BRCA2 Genes: Mutations in the BRCA1 and BRCA2 genes are the most well-known genetic factors associated with hereditary breast and ovarian cancer syndrome (HBOC). Individuals carrying mutations in these genes have an increased risk of developing breast and ovarian cancers. Other Genes: Apart from BRCA1 and BRCA2, mutations in other genes, such as TP53 (Li-Fraumeni syndrome), PTEN (Cowden syndrome), and PALB2, are also associated with an elevated risk of breast cancer. Hereditary Testing: Indications for Testing: Family History: Individuals with a strong family history of breast and ovarian cancers, especially if diagnosed at a young age, may be candidates for genetic testing. Early Onset: Breast cancer diagnosis at a young age (typically before age 50) may trigger consideration for genetic testing. Multiple Cancers: Families with a history of multiple cancers, such as breast and ovarian cancers or breast and prostate cancers, may raise suspicion for hereditary factors. Genetic Counseling: Before undergoing genetic testing, individuals are often advised to seek genetic counseling. This involves assessing the personal and family medical history to determine the likelihood of an inherited predisposition. Genetic counselors help individuals understand the implications of testing, potential outcomes, and the psychological impact of the results. Types of Genetic Testing: Sequencing: Direct sequencing of specific genes to identify mutations. Deletion/Duplication Analysis: Detects large rearrangements within the genes that may not be identified through sequencing alone. Multigene Panels: Testing for mutations in multiple genes associated with various hereditary cancer syndromes. #breastcancer #hereditarycancer #genetics #genetictesting #geneticcounseling #progenics Progenics Laboratories Pvt Ltd #brca1 #brca2

🧬 The Role of Genetics in Breast Cancer Risk: What You Need to Know 🌸 Proud to share our latest blog post from Narayana Health, shedding light on a crucial aspect of breast cancer risk - the role of genetics. 🌟 Breast cancer remains a significant health concern worldwide, and understanding the genetic factors involved can be a game-changer in prevention and early detection. Our comprehensive blog dives into the intricate relationship between genetics and breast cancer risk. Key Insights from the Blog: Genetic Predisposition: Learn about how certain genes, such as BRCA1 and BRCA2, can significantly increase the risk of developing breast cancer. These genes are crucial in maintaining the integrity of our DNA, and mutations can lead to cancer. Family History: Explore how a family history of breast cancer can indicate a higher genetic risk, emphasizing the importance of genetic counseling and testing for those with a familial connection to the disease. Genetic Testing: Discover the advancements in genetic testing that allow for the identification of high-risk individuals. Early detection through genetic testing can lead to proactive monitoring and preventive measures. Personalized Risk Assessment: Understand the importance of personalized risk assessments that consider both genetic and non-genetic factors to provide a comprehensive evaluation of breast cancer risk. Preventive Strategies: Insights into preventive strategies for those at high genetic risk, including lifestyle modifications, medical interventions, and, in some cases, prophylactic surgeries. Our commitment to advancing breast cancer research and treatment is unwavering. By understanding the genetic components of breast cancer, we can move towards more effective prevention, early detection, and personalized treatment plans. 💪💗 For an in-depth read, check out the full blog here: Role of Genetics in Breast Cancer Risk Let's continue to raise awareness and promote education about the genetic factors that can influence breast cancer risk. Knowledge is power, and together, we can make a difference. #BreastCancerAwareness #Genetics #NarayanaHealth #CancerPrevention #HealthEducation

In a new #analysis of #genetic #susceptibility to #kidney #cancer , an #international #team of #researchers has identified 50 new #areas across the #genome that are associated with the #risk of developing #kidney #cancer . These #insights could one day be used to #advance our #understanding of the #molecular basis of kidney cancer, #inform #screening #efforts for those at highest risk, and identify new #drug #targets . The #study was led by #scientists at the National Cancer Institute (#nci), part of the National Institutes of Health (#nih). A previous genome-wide association study (GWAS) of #people of European #ancestry identified 13 regions of the #genome that are associated with kidney cancer risk. However, the study population was not #diverse . To identify additional regions, researchers conducted a GWAS in #participants of many different genetic ancestries that included 29,020 people with kidney cancer and 835,670 people without kidney cancer. Analysis of the #data , which came from published #studies, #biobanks , and a new study, resulted in the #identification of 50 new regions associated with the risk of developing kidney cancer, bringing the total #number of such regions to 63. https://lnkd.in/eaHdidRp

Thousands of people with Jewish ancestry are to be offered a genetic test owing to their higher risk of some cancers. NHS England is rolling out a national BRCA gene testing programme to pick up changes that push up cancer risk, with anyone over 18 with Jewish ancestry offered a simple saliva test. To learn more: https://lnkd.in/d_i5mGwS #GeneticTesting #Genomics #Cancer #Oncology #Saliva #BRCA #BRCA1 #BRCA2 #CancerResearch #Samples #Biobank #Biobanking #Repository #OvarianCancer #NHS #Medical #Research #SalivaTest #GeneticRisk Peter Johnson