MSD’s Post

In #neuroscience, new powerful imaging technologies and insights from human genetics are helping us better understand disease-related changes in the brain. Hear from our scientists on how these rapidly emerging insights are informing our research in neurologic disorders. Listen to the full podcast: http://merck.us/3VWVx37

Turning spatial omics data from the brain into actionable insights 🧠✨ If you’re leveraging Spatial Omics techniques to explore brain tissue and uncover new drug targets for Alzheimer's disease, Parkinson's disease, or other neurological disorders, precise data analysis is key. 🔬💡 Check out our Astrocyte Segmentation, one key feature of our neuroscience package helping you to turn your data into results. By the way, ariadne.ai is expanding its neuroscience package within our cloud-based spatial biology analysis software! Stay tuned for more features or join us in 2 weeks at the #SpatialBiologyEU24 in Basel #Neuroscience #SpatialBiology #DrugDiscovery #Alzheimers #Parkinsons #NeurodegenerativeDiseases #Research #Astrocytes #AriadneAI

Typical customer projects and their solution: Cell count -> Segmentation Ratio of different cell types -> Segmentation (multiple classes) Cell size -> Segmentation Cell count per tissue region -> Segmentation (Tissues and cells) Cell migration assay -> Segmentation (Cell tracking is simple if the segmentation is accurate) Cell proximity -> Segmentation Artifact removal -> Segmentation ... I could continue this list forever 😁 My point is that an accurate cell segmentation is key to almost all downstream assays. Now you know why cell segmentation is our key focus ariadne.ai ag #imageanalysis #imageprocessing #biology #microscopy

In vitro brain models are key for developing treatments for neurodegenerative and neuroinflammatory diseases. However, current tools often fall short, extending research timelines. Join Dr. Will Bernard of bit.bio and Dr. Martin Engel of Inventia Life Science as they present advanced methods for creating scalable 2D and 3D brain co-culture models. Register here: https://lnkd.in/e2mSA2Pz #neuroscience #brainmodels

In vitro brain models are key for developing treatments for neurodegenerative and neuroinflammatory diseases. However, current tools often fall short, extending research timelines. Join Dr. William Bernard of bit.bio and Dr. Martin Engel of Inventia Life Sciences as they present advanced methods for creating scalable 2D and 3D brain co-culture models. Register here: https://lnkd.in/e2mSA2Pz #neuroscience #brainmodels bit.bio Inventia Life Science

In a study recently published in PNAS, researchers led by Wayne Sossin at The Neuro found that neurons have a protein synthesis "pause" button that other cells do not. This allows neurons to make proteins at the synapse which is far away from the parts of the cell where proteins are usually made. Mutations in genes responsible for this function are linked to neurodevelopmental disorders like autism. Understanding this process helps reveal their underlying mechanisms. Learn more here: https://lnkd.in/gsi7R9ck #neuroscience #cellularbiology Transforming Autism Care Consortium (TACC) Azrieli Centre for Autism Research (ACAR)

🧠🐁 Decoding the Human Brain: Breakthroughs from Mouse Brain Mapping 🌐 Recent studies highlighted by SciTechDaily are transforming our understanding of the human brain: High-resolution imaging and genetic analysis of mouse brains reveal parallels to human neural processes. These findings are instrumental in exploring treatments for neurological disorders. It exemplifies the power of animal models in advancing human health research. 🔍 A deeper dive into these studies: https://lnkd.in/dNw3vKhs #Neuroscience #BrainMapping #MedicalResearch

Princeton University researchers have created the first complete brain map of an adult fruit fly (Drosophila melanogaster). Using AI and human collaboration, they mapped 139,000 neurons and tens of millions of connections, resulting in a detailed "Google Map" of the brain. This connectome was generated from 21 million images, aiding in the study of brain functions and neurological disorders. Given the genetic similarities between fruit flies and humans, this research is a significant step toward understanding human brain wiring and developing treatments for brain diseases. #Neuroscience #BrainMapping #FruitFly #Drosophila #AI #Research #PrincetonUniversity #Connectome #BrainHealth #NeurologicalDisorders #Genetics #ScientificDiscovery

We are thrilled to announce that Quanterix and Alamar Biosciences are the official sponsors of our upcoming event: 2nd Annual Fluid and Imaging Biomarkers and Endpoints in Neuroscience! 🔬 Quanterix is at the forefront of advancing biomarker science through its innovative digital immunoassay platforms. Their cutting-edge technology perfectly complements our focus on fluid and imaging biomarkers in neuroscience. 🧬 Alamar Biosciences, Inc. stands out for its high-quality reagents and assays that drive next-generation bioscience solutions. Their expertise and commitment are vital as we explore new frontiers in neuroscience research. We are honoured to have these leading companies partner with us, and we can't wait to dive into the latest advancements and insights in Neuro Biomarkers together. Learn More: https://ter.li/baqehw #CNS #DrugDelivery #Neuroscience #Neuroscience #Biomarkers #CNSResearch #ImagingBiomarkers #NeuroImaging #FluidBiomarkers #BrainResearch #NeuroScienceResearch #Neurology #ClinicalNeuroscience

“It is a real adrenaline rush when things suddenly make sense and everything that was hidden and faded is now clear” – Zala Zebec, PhD at BRIC. It is #brainawarenessweek, and to honor research in the brain and #neurobiology we share our enthusiasm on the brain and on brain science. Meet Zala Zebec. She is doing her PhD in neuroimmunology in Shohreh Issazadeh-Navikas's group at BRIC. Zala is driven by her curiosity about the complexity of the brain at the molecular level and how even the smallest discovery might benefit a patient in the long run. “I always try to think about the patient, even though I do basic research in neuroimmunology, which is often far from the clinic. So, whenever I'm doing experiments, although they're often not directly related to patients at all I still try to think that maybe if I can figure out how this super specific signaling pathway works, then it might in the long run help a Parkinsons patient who is currently only getting drugs for symptomatic relief. I might uncover just a small piece of the puzzle, like one phosphorylation site or one tiny, seemingly, super meaningless thing in the whole range of the world, but in my mind, it's so nice to finally understand the interaction at the molecular level. And this tiny uncovering might lead to the next piece being revealed -and then in 30, 40 or 50 years all the pieces of the puzzle might come together.” During Brain Awareness Week five researchers from BRIC will share their enthusiasm on the brain. #brainweek #brainawarenessweek #brainhealth #neuroscience #neurobilogy