Mehul I Solanki’s Post

SURGICAL ALTERNATIVE OF BIOPSY IN CAVERNOUS SINUS The etiology of cavernous sinus (CS) lesions remains difficult to determine due to the wide range of pathological processes and despite the development of neuroimaging techniques. Microsurgery is not yet appropriate to biopsy CS lesions for diagnostic purposes; computed tomography-guided fine-needle aspiration, which is mostly negative for malignancy, has rarely been attempted. I present to you a new application of endoscopic endonasal surgery for the biopsy of lesions that arise or invade the CS. Primary DBLCL in the cavernous sinus is extremely rare in clinical practice, early diagnosis is crucial to standardize neuro-oncological treatment and improve the prognosis of patients. We analyzed the case of a patient with diffuse large cell B lymphoma (germinal center maturation) that occurred in the cavernous sinus and orbit. Due to the poor prognosis of cavernous sinus lymphomas, whether primary or secondary, early diagnosis is essential. Our case demonstrates the need for physician awareness and the importance of maintaining a broad differential diagnosis.Under direct endoscopic visualization, the technique is safe, effective, precise and provides a surgical route that can be added to the arsenal for the treatment of pathological conditions in this region.

Gastric Cancer Surgery: Balancing Oncological Efficacy against Postoperative Morbidity and Function Detriment Significant progress has been made in the surgical management of gastric cancer over the years, and previous discrepancies in surgical practice between different parts of the world have gradually lessened. A transition from the earlier period of progressively more extensive surgery to the current trend of a more tailored and evidence-based approach is clear. Prophylactic resection of adjacent anatomical structures or neighboring organs and extensive lymph node dissections that were once assumed to increase the chances of long-term survival are now performed selectively. Laparoscopic gastrectomy has been widely adopted and its indications have steadily expanded, from early cancers located in the distal part of the stomach, to locally advanced tumors where total gastrectomy is required. In parallel, function-preserving surgery has also evolved and now constitutes a valid option for early gastric cancer. Pylorus-preserving and proximal gastrectomy have improved the postoperative quality of life of patients, and sentinel node navigation surgery is being explored as the next step in the process of further refining the minimally invasive concept. Moreover, innovative techniques such as indocyanine green fluorescence imaging and robot-assisted gastrectomy are being introduced in clinical practice. These technologies hold promise for enhancing surgical precision, ultimately improving the oncological and functional outcomes. https://lnkd.in/ew425Ksi #ICG #indocyaninegreen #fluorescence #fluorescent #guidedsurgery #surgery #surgeon #imaging #thinkgreen #patients #safety #surgical #laparoscopic #cancer #gastric

Hypofractionated (HF) whole-breast irradiation with simultaneous integrated boost (SIB) can be considered a standard of care for adjuvant radiotherapy after breast conserving surgery. Patients (n = 2,324) were randomized 1-to-1 either to the experimental arm (40 Gy to the breast; 48 Gy to the tumor bed in 16 fractions) or to the control group (physician's choice between conventional fractionation with SIB or sequential tumor bed boost [seqB], or HF with seqB) from 2015-2019. Local control at 5 years was 98.2% in the experimental arm and 98% in the control arm (HR = 1.08). HYPOSIB trial is one of three large trials, along with IMPORT HIGH  and RTOG 1005 , that have shown HF with SIB is feasible and safe.

Indocyanine green fluorescence angiography could reduce the risk of anastomotic leakage in rectal cancer surgery: a systematic review and meta-analysis of randomized controlled trials Aim: Several papers have shown that use of indocyanine green (ICG) decreases incidence of anastomotic leakage (AL) during colonic surgery, but no clear evidence has been found for rectal cancer surgery. Therefore, with this systematic review and meta-analysis of randomized controlled trials (RCTs) we aimed to assess if ICG could also reduce risk of AL in rectal cancer surgery. Method: PubMed, Scopus, CINAHL and Cochrane databases were searched for RCTs assessing the effect of intraoperative ICG on the incidence of AL of the colorectal anastomosis. Pooled relative risk (RR) and pooled risk difference (RD) were obtained using models with random effects. Risk of bias was evaluated with the Rob2 tool and the quality of evidence was assessed using the GRADE Pro tool. Results: Four RCTs were included for analysis, with a total of 1510 patients (743 controls and 767 ICG patients). The rate of AL was 9% in the ICG group (69/767) and 13.9% (103/743) in the control group (p = 0.003, RR -0.5, 95% CI -0.827 to -0.172, heterogeneity test 0%, p = 0.460). The RD in terms of incidence of AL was significantly decreased by 4.51% (p = 0.031, 95% CI -0.086 to -0.004, heterogeneity test 28%, p = 0.182) when using ICG. Conclusion: Our meta-analysis suggested that use of ICG during rectal cancer surgery could reduce the rate of AL. https://lnkd.in/ehYMg6Qe Alessio Lucarini Marion Orville Pr. Yves Panis Andrea Martina Guida  CMC Ambroise Paré / Pierre Cherest / Hartmann Sapienza Università di Roma University of Rome Tor Vergata #ICG #indocyaninegreen #fluorescenceguidedsurgery #fluorescent #guidedsurgery #surgery #surgeon #imaging #thinkgreen #patients #surgical #rectalcancer #indocyaninegreen #cancersurgery #cancer  

Publication Alert 📣 Our latest paper investigating the surgical treatment work-up of #gastric and #esophageal #cancer in Denmark by Astrid Kolind Christensen et.al. is out: https://lnkd.in/dD67Tepr Key Findings: * >950 patients were analyzed, undergoing both initial and specialized endoscopies prior to surgery. * 68% of initial endoscopies lacked sufficient preoperative tumor information. * In 12% of cases, findings from specialized endoscopies led to significant changes in surgical strategy. * Repeated endoscopy at specialized centers was identified as a critical factor in ensuring proper surgical treatment. This research underscores the importance of centralized care and specialized expertise in the treatment of #gastroesophageal cancer.

Surgery after neoadjuvant treatment with immune checkpoint inhibitors (ICIs) is safe for patients with locally advanced renal cell carcinoma (RCC). https://brnw.ch/21wFY8S

Cyberknife is one of the most advanced forms of radiosurgery. The treatment is preferred for complex cancer treatment where direct surgery is not possible. The #cyberknife treatment delivers high doses of radiation to destroy tumours. The treatment allows #cancer patients to live a disease-free life with a 97-100% success rate. There are several advantages of Cyberknife treatment. 1) The procedure is totally non-invasive 2) No anesthesia required 3) Recovery is almost immediate 4) It is a painless procedure 5) Low risk of damages A patient from Yemen came for her cancer treatment. She was suffering from a brain tumour. CureIndia assisted the patient and her family with the right treatment in India. One of the top cancer doctors in Delhi provided the treatment to the patient. She received 3 sessions. Watch the full video and listen to the testimonial to know the patient's experience. Read More on Cyberknife: https://lnkd.in/gvMCmX7M Video Link: https://lnkd.in/gXksUJhx #cyberknife #cyberknifetreatment #noninvasivecancertreatment #radiotherapy #radiosurgery #cancertreatment #painlesstreatment #medicalvalueplatform #medicaltourism #medicaltourismindia #medicaltravelabroad #travelabroad #CureIndia

Hot topic in upper GI surgery! There is no conference without discussions on the extend of lymph node dissection in esophageal cancer surgery. Even when we can reach consensus on the extend, its anatomical boundaries and clearance of the adjacent structures vary between centers. #esophagectomy #Radboudumc #Amsterdamumc

Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes

📃Scientific paper: Primary squamous cell carcinoma of the thyroid treated with concurrent chemoradiation and palliative immunotherapy: a case report Abstract: Background Primary squamous cell carcinoma of the thyroid is a very rare malignancy with aggressive growth and poor prognosis. There is currently no consensus for treatment modality, however, most patients with primary squamous cell carcinoma of the thyroid are treated with surgery and adjuvant chemoradiation. Case presentation We report a rare case of primary squamous cell carcinoma of the thyroid in a 68-year-old White male who underwent chemoradiation and palliative immunotherapy after declining surgery. He was treated with intensity-modulated radiation therapy to 70 Gy in 35 fractions, with concurrent carboplatin–paclitaxel and palliative pembrolizumab. Local thyroid disease recurrence occurred at 6 months post-chemoradiation, and the patient died at 16 months post-chemoradiation. Conclusions This is the first case report demonstrating the use of pembrolizumab as palliative therapy for primary squamous cell carcinoma of the thyroid. Our study also highlights the importance of chemoradiation in decreasing primary mass size and immunotherapy in preventing metastatic disease progression. Continued on ES/IODE ➡️ https://etcse.fr/7Axbm ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.