Journal of Intensive Medicine’s Post

Output dysregulation of the substantia nigra pars reticulata (SNr) and globus pallidus internal segment contribute to PD motor symptoms. Increasing SNr activity with ChR2 was found to reduce levodopa-induced dyskinesia in a PD mouse model. https://loom.ly/rw_yz90

Dr. Amir Borhani's article discusses the macro- and microhemodynamics underlying liver congestion, proposes a more inclusive approach, and presents a diagnostic algorithm for approaching hypervascular liver lesions. https://bit.ly/4b0YdTc @AmirBorhaniMD #abdominalimaging

Vascular aging is a multifaceted contributor to ischemic stroke, which is an age-related condition, in which atherosclerotic plaque ruptures to block blood supply to a part of the brain for long enough to cause dysfunction, reperfusion injury, and cell death. #worldhealth #antiaging #aging #regenerativemedicine #medicne #cardiovesculardisease #hearthealth #stroke #clinicalresearch #health https://lnkd.in/gnUi84hM

#Research Myelin oligodendrocyte glycoprotein antibody associated disease. Published in the Journal Acta Neurológica Colombiana, From our Esclerosis Multiple Reference Center. 👉 https://lnkd.in/eR2qZ7KF Results: The clinical manifestations are heterogeneous, ranging from optic neuritis or myelitis to multifocal CNS demyelination or cortical encephalitis. There have been described characteristic MRI features that increase the diagnostic suspicion, such as perineural optic nerve enhancement, spinal cord H-sign or T2-lesion resolution over time. The diagnosis is based on the detection of specific G- immunoglobulins against MOG, in the suggestive clinical context. Acute treatment is based on high dose steroids and maintenance treatment is generally reserved for relapsing cases or patients with severe residual disability after the first attack. #Myelin #OpticNeuritis #Serology #Immunosuppression

Niacin Treatment of Stroke Increases Synaptic Plasticity and Axon Growth i https://lnkd.in/e5peai8X

Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association Stroke. 2024;55:e91–e106. DOI: 10.1161/STR.0000000000000457 Conclusion: -Cervical artery dissection occurs as a result of the interplay among risk factors, minor trauma, anatomic and congenital abnormalities, and genetic predisposition. - In patients with acute ischemic stroke due to cervical artery dissection, acute treatment strategies such as thrombolysis and mechanical thrombectomy are reasonable in otherwise eligible patients. -We suggest that the antithrombotic therapy choice be individualized and continued for at least 3 to 6 months. -The risk of recurrent dissection is low, and preventive measures may be considered early after the diagnosis and continued in high- risk patients.

Discussions about cardiac amyloidosis are hotter than hot in the cardiology world. But do you know the real facts? Hear from Dr. Justin Grodin, a cardiologist and co-director of the UT Southwestern Multidisciplinary Amyloidosis Program, goes through the diagnostic process for AL and ATTR cardiac amyloidosis. He discusses key differences between AL and ATTR, and how typing of amyloidosis is paramount to consider in order to subsequently develop a treatment plan. He goes through a diagnostic algorithm to help clinicians arrive at an accurate diagnosis. Finally, he stresses the importance of genetic testing and counseling for ATTR to differentiate between wild-type and hereditary, as well as identifying the specific genetic variant. https://lnkd.in/eBV-kq7w 

🚨 Is there a better option than retransplantation for hepatic artery thrombosis in liver transplant patients? The answer might surprise you 🤯 Explore the latest from @JVIRmedia on mechanical thrombectomy as a potential alternative! 🔗 Full study: https://lnkd.in/g95XDzgY

New insights published in Cardiovascular Research highlight critical differences in the cellular causes of heart failure with preserved ejection fraction (HFpEF) between sexes. Adding to a growing body of evidence that heart failure is not one-size-fits-all, these findings underscore the urgent need for sex-specific treatment approaches to better address and manage people living with HFpEF. 

Free article ! Review article Neurosurgical therapy possibilities in treatment of Huntington disease: An update Highlights • Treatment of Huntington's disease has evolved from surgical to advanced interventions. • Surgical therapies have shown effectiveness in controlling chorea and other motor symptoms. • Cell transplants and neurotrophic factors have emerged as approaches to modulate the disease. • Ethical considerations and risks make significant challenges for their clinical implementation. • Significant challenges remain in efficacy, safety, and accessibility of these therapies. IAPRD Secretariat Log in : https://lnkd.in/gpDERb4a