CR2TI UMR 1064 Nantes’ Post

The risk of early heart failure after heart transplantation is lower if the donor heart is stored in a so-called heart-in-a-box instead of in the usual cooler with ice. This is according to a study where researchers at the Sahlgrenska Academy at University of Gothenburg are now presenting the results. Goran Dellgren is Professor of Transplantation Surgery at Sahlgrenska Academy at the University of Gothenburg, and a cardiothoracic surgeon at Sahlgrenska University Hospital and the Swedish Principal Investigator of the study, responsible for about twenty participants: “The results represent a breakthrough in transplantation, which could expand the field. Used correctly, the heart-in-a-box can reduce a number of complications that otherwise often result in suffering, poor outcomes, in the worst cases premature death, and also high costs,” he says. “In terms of time, organs can also be shipped longer distances, thus making more organs available for transplantation. It is also likely that we can start using less ideal organs from older donors, which could increase the number of heart transplants,” concludes Göran. Read more about the study on our website: https://lnkd.in/dAazPzsw

Since November 2020 the UMCG has been investigating whether it is safe to preserve donor livers much longer in a perfusion machine. A new study published in The Lancet showed that this was safe: a donor liver can deliberately be preserved longer, rather than transplanted immediately. There was no difference in transplant outcome for the liver transplant recipients. As a result of that, it has become standard practice since the beginning of 2023 at UMCG to perform virtually all hour-long liver transplants during daytime. The benefits of the new prolonged preservation method are great. According to Vincent de Meijer, professor of surgery and head of the liver transplant program at UMCG, it potentially transforms the field by turning liver transplantation from an acute surgery into a daytime operation. Curious to find out more? https://lnkd.in/duZzia6h #perfusion #transplantation #livertransplantation

Researchers in the thoracic immunobiology laboratory in the Division of Cardiothoracic Surgery have diligently studied the mechanisms concerning the immune system's response to organ transplantation. In a recent study, published in the Journal of Clinical Investigation, lung transplant surgeon Ruben Nava, MD, and colleagues within the laboratory investigated the body's immune response that occurs in lung transplantation and the signaling proteins responsible for the development of ischemia-reperfusion injury, a phenomenon linked to organ rejection. Learn about about the team's research: https://bit.ly/4byxn54

𝐄𝐱𝐜𝐢𝐭𝐢𝐧𝐠 𝐧𝐞𝐰 𝐫𝐞𝐬𝐮𝐥𝐭𝐬 𝐟𝐨𝐫 𝐗𝐕𝐈𝐕𝐎’𝐬 𝐋𝐢𝐯𝐞𝐫 𝐀𝐬𝐬𝐢𝐬𝐭: 𝐀 𝐬𝐭𝐮𝐝𝐲 𝐜𝐨𝐧𝐝𝐮𝐜𝐭𝐞𝐝 𝐛𝐲 UMCG research 𝐢𝐧 𝐭𝐡𝐞 𝐍𝐞𝐭𝐡𝐞𝐫𝐥𝐚𝐧𝐝𝐬 𝐜𝐨𝐧𝐜𝐥𝐮𝐝𝐞𝐬 𝐭𝐡𝐚𝐭 𝐚 𝐝𝐨𝐧𝐨𝐫 𝐥𝐢𝐯𝐞𝐫 𝐜𝐚𝐧 𝐛𝐞 𝐬𝐚𝐟𝐞𝐥𝐲 𝐩𝐫𝐞𝐬𝐞𝐫𝐯𝐞𝐝 𝐟𝐨𝐫 𝐚 𝐥𝐨𝐧𝐠𝐞𝐫 𝐭𝐢𝐦𝐞, 𝐢𝐧𝐬𝐭𝐞𝐚𝐝 𝐨𝐟 𝐛𝐞𝐢𝐧𝐠 𝐭𝐫𝐚𝐧𝐬𝐩𝐥𝐚𝐧𝐭𝐞𝐝 𝐢𝐦𝐦𝐞𝐝𝐢𝐚𝐭𝐞𝐥𝐲, 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐜𝐨𝐦𝐩𝐫𝐨𝐦𝐢𝐬𝐢𝐧𝐠 𝐩𝐚𝐭𝐢𝐞𝐧𝐭 𝐬𝐚𝐟𝐞𝐭𝐲. This finding implies that liver transplantation has the potential to transition from primarily a nighttime procedure to a daytime procedure, facilitated by perfusion machines. XVIVO extends its congratulations to Professor Vincent de Meijer and his team, who, as a standard practice since the beginning of 2023, have been performing liver transplants during daytime using XVIVO’s Liver Assist. #extendinghorizons #machineperfusion #prolongedpreservation #liver #transplant #HOPE #DHOPE #kudos #collaboration

𝗟𝗶𝘃𝗲𝗿 𝗧𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁𝗮𝘁𝗶𝗼𝗻 𝗘𝘅𝗽𝗹𝗮𝗶𝗻𝗲𝗱: 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗿𝗼𝗺 𝗗𝗿. 𝗦𝗼𝗻𝗮𝗹 𝗔𝘀𝘁𝗵𝗮𝗻𝗮 | 𝗔𝘀𝘁𝗲𝗿 𝗖𝗠𝗜 𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 Join Dr. Sonal Asthana, Lead Consultant in HPB & Liver Transplant Surgery at Aster CMI Hospital, as he provides an in-depth look at liver transplantation. In this informative video, Dr. Asthana discusses the indications for liver transplants, the surgical process, and what patients can expect during recovery. Learn about the latest advancements in liver transplant surgery and how they improve patient outcomes. Whether you’re a patient, a caregiver, or simply interested in the field of liver transplantation, this video offers valuable insights from a leading expert. Watch now to learn more about the life-saving potential of liver transplants. #LiverTransplant #AsterCMIHospital #DrSonalAsthana #HPBSurgery #LiverHealth #TransplantSurgery #MedicalAdvancements #PatientCare #HealthEducation

Introduction of Organ Transplantation (1954) Overview: The first successful human organ transplant, a kidney transplant, was performed by Dr. Joseph Murray and his team in 1954 at Peter Bent Brigham Hospital in Boston. The surgery involved transferring a kidney from one identical twin to another, minimizing the risk of rejection. This pioneering surgery demonstrated that organ transplantation could be a viable treatment for end-stage organ failure. Impact: Organ transplantation has since become a critical and life-saving procedure for patients with failing organs, including kidneys, livers, hearts, and lungs. Advances in immunosuppressive drugs have made it possible to transplant organs between unrelated individuals, further expanding the potential of transplantation. The field continues to evolve with new techniques and #innovations, offering hope to many patients. #organtransplant #kidneytransplant #JosephMurray #immunosuppression. #OrganDonation #TransplantSurgery #LifeSavingCare

𝗕𝗮𝗿𝗶𝗮𝘁𝗿𝗶𝗰 𝘀𝘂𝗿𝗴𝗲𝗿𝘆 𝗶𝗻 𝗽𝗮𝘁𝗶𝗲𝗻𝘁 𝘄𝗶𝘁𝗵 𝗰𝗶𝗿𝗿𝗵𝗼𝘀𝗶𝘀 𝗿𝗲𝗱𝘂𝗰𝗲𝗱 𝟭𝟱-𝘆𝗲𝗮𝗿 𝗠𝗔𝗟𝗢 𝗿𝗶𝘀𝗸 𝗯𝘆 𝟳𝟮% 𝗮𝗻𝗱 𝗳𝗶𝗿𝘀𝘁 𝗱𝗲𝗰𝗼𝗺𝗽𝗲𝗻𝘀𝗮𝘁𝗶𝗼𝗻 𝗯𝘆 𝟴𝟬%. In the SPECCIAL study from Cleveland Clinic, researchers analyzed 62 metabolic surgery patients and 106 nonsurgical control patients, all with compensated MASH-related cirrhosis. Follow-up was over a 25-year period with a mean follow-up of 10.0±4.5 years. The primary outcome, Major Adverse Liver Outcome (MALO), included first occurrence of ascites, variceal hemorrhage, hepatic encephalopathy, hepatocellular carcinoma, liver transplantation, or all-cause mortality. Secondary outcome, the progression to decompensation, included first occurrence of ascites, variceal hemorrhage, or hepatic encephalopathy. Read More: https://hubs.la/Q02FPLfH0 #MASHcirrhosis #bariatricsurgery Cleveland Clinic

On the Cover: Acute-on-Chronic Liver Failure: From Immunopathogenesis to Transplantation The May issue, featuring two articles on acute-on-chronic liver failure, kicks off a Virtual Special Issue to which articles will be added in the coming months. Artru and McPhail detail the immune dysfunction that drives this high mortality syndrome to rationalize future immune-based therapeutic strategies. Bajaj, in collaboration with colleagues covering six continents, critically examines geographic disparities in (timely) access to liver transplantation in both the developed and the developing regions of the world. We urge you to look for additional articles on transplant-related topics of acute-on-chronic liver failure. Cover design by Megan Llewellyn, CMI, Department of Surgery, Duke University. https://lnkd.in/g7q_E_bB

Montefiore Einstein has performed a groundbreaking surgical procedure led by Ahmed A. Aboumohamed, MD, Director, Robotic and Minimally Invasive Urologic Surgery. The innovative surgery, called Robotic radical nephrectomy with IVC thrombectomy, was performed in a completely robotic, minimally invasive approach. Dr. Aboumohamed collaborated with Charbel Chalouhy, MD, Department of Urology, and Marie E. Le, MD, Center for Transplantation, to be the first in the Bronx and Westchester County area to perform this type of surgery. Robotic radical nephrectomy with IVC thrombectomy is only performed in very few select tertiary hospitals across the country. Traditionally, such complex procedures have been performed through open surgery due to the advanced nature of the disease. However, Dr. Aboumohamed and esteemed colleagues used robotics to perform the removal of a large kidney tumor with inferior vena cava (IVC) tumor thrombus extension, marking a pivotal moment in progress toward innovative healthcare solutions in Montefiore Einstein's Health System. #Montefiore #MontefioreEinstein  #MontefioreEinsteinComprehensiveCancerCenter

🌟 ILTS members enjoy FREE access to the Liver Transplantation journal, delivering current, peer-reviewed articles on liver transplantation, surgery, and chronic liver disease. 📑 Don't miss out on the essential information you need to stay ahead in this evolving specialty. Click the link to join and access your free subscription: https://loom.ly/jiKXzw8 📚 #LiverTransplantation #LT #Transplantation #Anesthesia