HistoWiz’s Post

𝐄𝐦𝐛𝐚𝐫𝐤 𝐨𝐧 𝐚 𝐉𝐨𝐮𝐫𝐧𝐞𝐲 𝐰𝐢𝐭𝐡 𝐘𝐨𝐮𝐫 𝐏𝐞𝐞𝐫𝐬 𝐚𝐭 𝐒𝐩𝐚𝐭𝐢𝐚𝐥 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 𝟐𝟎𝟐𝟒! 🥼 On Day One, Track 2 will delve into 'Image Analysis, AI Powered Imaging & Digital Pathology for Spatial Biology,' featuring insights from leading experts including John Le Quesne, Ines Sequeira, Leo M. Carlin, Ilary Allodi, Cara Brodie, and Martin Fergie! 🧠 𝐇𝐞𝐫𝐞'𝐬 𝐰𝐡𝐚𝐭 𝐲𝐨𝐮'𝐥𝐥 𝐮𝐧𝐜𝐨𝐯𝐞𝐫: 🌟 Accelerating the discovery of novel biomarkers and drug targets using spatial imaging 🌟 Tissue imaging and analysis using advanced spatial profiling techniques 🌟 AI guided technology for spatial analysis 🌟 Imaging data analysis / how to set a spatial experiment 🌟 Relevant spatial parameters in different model systems ➡️📖 Dive into the full track information: https://hubs.la/Q02gf8Zv0 Which aspect of spatial biology are you most excited to explore? Comment below! 👇 #OGOmics #SpatialBiologyUK24 #ImageAnalysis #DigitalPathology

Automated Brain-Wide Identification of Microglia with The Translucence Teravoxel ToolKit (3TK) software. Pictured on the left, the images showcase Iba1 immunoreactivity in microglia. On the right, AI-powered 3D microglia labels are shown in a single 2D optical slice. Zoomed images show that the labels reveal detailed cellular morphology. These are 2D slices through 3D labels, and small seeming labels can be portions of microglia that project orthogonal to the 2D optical slice shown. Cell masks allow for counts, shape analysis, and fluorescence intensity measurements. The Translucence Teravoxel ToolKit (3TK) software then performs brain-wide regional quantification of independent object populations. AI-powered analytics provide a nuanced picture of microglia distribution, shape, and density– crucial for uncovering mechanisms associated with the development of various neurodegenerative diseases. Learn more about our AI-powered services and how to obtain precise cell identification and quantification. https://lnkd.in/gcfDpwy5 #TissueClearing, #3Dimaging, #Histology, #Microglia, #AI, #Quantification

The Integration of Computational and Digital Pathology into the clinic is emerging. This represents a paradigm shift when compared to traditional modes of microscopic diagnosis. One key element in this transition periord is overcoming communication barriers between pathologists and developers... too often these barriers prevent realization of the full potential of the available solutions. In this paper, started within the Pathology Innovation Collaborative Community under the leadership of Steven Hart – he initially proposed to address the above gap between pathologists and developers. Challenges include Standardization, Availability of data and annotation, Cost, Quality concerns, Security, and Transparency. In contrast there are levels of supervision - size and diversity of datasets, image augmentation, ensemble learning, bagging, stacking, boosting, over vs. underfitting, and performance assessment approaches and various metrics that converge into clinical use cases. The team includes Qiangqiang Gy, Ankush Patel, Matthew Hanna, Chris Garcia, Mark Zarella, David McClintock and Steven Hart - and I believe we were able to provide a comprehensive outline for the understanding of computational and clinical paradigms regarding the translational gap. Link to pubmed: https://lnkd.in/epKCB8ni DOI: 10.5858/arpa.2023-0250-RA Link to Archives: https://lnkd.in/eCFaJJpE #Digitalpathology #WSI #computationalpathology #biomarker #precisiononcology #diagnostics #laboratory #AI #machinelearning #regulation #training #tuning #testing #generative #histology #histopathology #coding #laboratory

It is always about #communication and how to improve it, especially in #pathology and all #healthcare! I am so glad Joe Lennerz is multilingual! #digitalpathology #AI #informatics

Join our "Sliding Into a Digital Cytology Workflow " Exhibitor Seminar at USCAP on Tuesday, March 26, at 12pm, Exhibitor Seminar Room 5. As #DigitalPathology gains ground in modern labs, many face the challenge of handling #cytology samples. While digital workflows benefit FFPE samples, optimizing cytology specimens with whole slide imaging and AI remains uncertain. #Coreplus will showcase their exploration of extended focal imaging, #WaterImmersion, and #AI, demonstrating improved workflow efficiency and results. Speakers: Marino de Socarraz: CEO, CorePlus; DPA Board Memeber; President, Precision Pathology Innovatoine Ben Cahoon: CEO, Techcyte Ryan Davis: Director Global Business, Digital Pathology and AI, #Epredia **Lunch will be provided for the first 50 attendees**

Another great Nature communications paper today ! This one describes a solution to build a correspondence between molecular-scale transcriptomics and tissue-scale atlases. The authors mapped tissue-scale mouse brain atlases to gene-based and cell-based transcriptomics data from #MERFISH and BARseq technologies and to histopathology and cross-species atlases to illustrate integration of diverse molecular and cellular datasets into a single coordinate system as a means of comparison and further atlas construction. For that work, the authors used serial #MERFISH sections from the Allen Institute which were produced under the BRAIN Initiative Cell Census Network (BICCN). Vizgen #MERSCOPE #MERFISH #SpatialTranscriptomics #SpatialBiology #SingleCell #SubCellular #OnlyRealDotsCount https://lnkd.in/e66zh6e5

Get ready to dive into the future of #Pathology with Vincenzo L’Imperio, Professor at the University of Milan-Bicocca and Vice-President of the ESDIP In this groundbreaking first pathology lesson of the ESDIP Academy, he unveils the transformative power of #DigitalPathology. From streamlining workflows to harnessing the power of #AI, discover how the field of pathology is undergoing its third major revolution! What’s in Store? - A complete overview of the pathology workflow and how digital tools are changing the game. - The journey from traditional analog methods to cutting-edge digital pathology. - How AI is revolutionizing tasks like cell detection, tumor grading, and predicting molecular alterations. - The challenges and solutions in digital pathology, ensuring accuracy and consistency across labs. Pathology has come a long way, and now, with the integration of digital tools and AI, the future is here. Don’t miss this chance to learn from a leader in the field and be at the forefront of the next big leap in pathology. Join Now the ESDIP academy: https://lnkd.in/dfTmZqB8 #DigitalPathology #AIinMedicine #PathologyRevolution #HealthcareInnovation

Check out our latest preprint on BioRxiv, introducing organellomics! Our team has developed an AI-driven approach to deep organellar phenotyping of human neurons, providing a systems-level view of cell architecture with 24 organelles. 🧠🔬 With over 1.5 million neuron images encoded, our 𝗡𝗢𝗩𝗔 (𝗡euronal 𝗢rganellomics 𝗩ision 𝗔tlas) enables holistic insights into cellular biology. Shoutout to an amazing team, including Sagy Krispin, Nancy Y., Welmoed van Zuiden Eran Hornstein, and many others!🌟👩💻👨💼 #organellomics #AI #cellbiology #neurons #science

"Expertise doesn't have to be at a university. Expertise can be anywhere." New Episode Now Out! SEASON 3, EPISODE 9: Ken Bloom of Nucleai, "It Has to be Led by Somebody" We examine the beginnings of telepathology, which led to what we now know as #digital #pathology in the 1980s. We trace the journey from then to now, focusing on seminal events in the industry, such as computational pathology, computer-assisted image analysis, the development of CPT codes, the importance of the TCPC split, particularly in the reference lab setting. We also discuss the democratization of immunohistochemistry in connection with digital pathology and touch on recent developments in the assessment of  tumor heterogeneity, #AI algorithms, and spatial analysis. Additionally, we explore the role of pathologists in the era of precision medicine, and the potential for integration of pathology with radiology. Listen to Digital Pathology Today on all major podcast platforms or https://lnkd.in/e6YHDMNy

Are you passionate about the #digitization of microscopy workflows in research and pathology?  Dive into our curated collection of on-demand webinars, where we explore a spectrum of themes ranging from #bestpractices in digital microscopy workflows to the transforming impact of AI in research. The insights you crave are just a click away—join us for knowledge-packed sessions that cater to your interests. Details in comment: 👉 https://lnkd.in/eSUyF9Pa. #digitalmicroscopy #pathology #research #ondemandwebinar