Google Research’s Post

Sharing our blog post about utilizing unsupervised representation learning on clinical data for genomic discovery! This article summarizes our latest research published in Nature Genetics: - Google Research Blog: https://goo.gle/3y5UdD7 - Nature Genetics: https://lnkd.in/exUr6WM2

一个典型的无监督深度学习成功研究案例👍 我的粗浅理解：通过VAE把高维临床数据(HDCD)压缩到较低维度潜在空间，然后基于基因关联和专家定义特征（Expert-defined Features, EDFs），再对潜在空间的数据进行干涉和调整。🤔 --- A typical success case study of unsupervised deep learning👍 My basic understanding is: High-dimensional clinical data (HDCD) is compressed into a lower-dimensional latent space using Variational Autoencoders (VAEs). Then, based on gene associations and expert-defined features (EDFs), the data in the latent space is further manipulated and adjusted. 🤔

Another Friday means another group of insightful articles on Medical Science and Technology. The first publication discusses how a rare genetic variant that causes short stature in Laron syndrome may also extend people's lives by protecting them from heart disease . https://lnkd.in/gpEXWeTC Next up is an article that spotlights scientists that have designed a solar panel-like pacemaker that can precisely control heartbeats. https://lnkd.in/gpEXWeTC Lastly is an article telling us that researchers now know the cells responsible for the coughing that sometimes follows drinking water. Neuroendocrine cells in the larynx and trachea, which make up the passageway from the mouth to the lungs, can sense water and acid passing through. These cells then communicate with the nervous system to trigger reflexes, like coughing. https://lnkd.in/g4fUyiCs #manhattanlife #medicalscience #healthcarefindings #medicaltechnology

Epoch 38: SURVEY OF THE CRISPR CLINICAL LANDSCAPE 👉 101 History 👉 Disease areas being targeted 👉 Accessible tissue types 👉 Future Directions 👉 Upcoming catalysts https://lnkd.in/dEkBy2bY

Happy to be a part of this fabulous research with ARPAN DEY, Prof. Sudipta Maiti and the team! Aβ and ApoE are important players in bringing about Alzheimer's disease. This work shows how a brief interaction with ApoE leaves a toxic mark on Aβ oligomers. This toxic signature on Aβ can be leveraged for drug development and as a potential biomarker to detect Alzheimer's. Read our work, fresh off the press, here (beautiful graphical abstract by Arpan): https://lnkd.in/gGzVY29b

From your lifestyle to your genetics, there's a range of controllable and uncontrollable factors that determine how difficult weight loss is. Discover how our personalized medical approach accounts for it all on the blog. https://lnkd.in/gWMhnNPP

Hong W, Zippi M, Wang G, Jin X, He W and Goyal H (2024) Editorial: Immune dysfunction in acute pancreatitis: from bench to bedside research. Front. Immunol. 15:1462563. doi: 10.3389/fimmu.2024.1462563

Really pleased to report the publication of our manuscript: Profiling of circulating glial cells for accurate blood-based diagnosis of glial malignancies: https://lnkd.in/erZcJX7u

In our #BioPhysicsFeature this week, scientists have made a breakthrough in diabetes research using islet-VMO! By studying the pancreas in an environment that mimics a real body, researchers can discover more about diabetes and how to treat it: https://ow.ly/VmtB50R2pvA

The manifestation of an immune response can result in #ocular inflammation impacting study duration, power, and the ability to meet objectives. Using immunosuppression can help mitigate inflammatory impact but may not completely quench the response. In this presentation, we explore the ethical and scientific considerations for using immunosuppression in non-clinical ocular studies and the benefits, concerns, and strategies for its use. https://okt.to/4APwz6