🧬Benefits of routine genetic testing in DCM:
👉 Dilated cardiomyopathy (DCM) is a condition where the heart muscle is weakened, leading to an enlargement of the left ventricle.
👉In its advanced stages, DCM often requires interventions such as a durable left ventricular assist device or a heart transplant.
👉While DCM is recognized to have a genetic foundation, the investigation of rare variants in advanced stages of the disease has only recently gained attention.
👉A recent study has demonstrated the effectiveness of genetic testing in advanced DCM cases. Patients experiencing advanced DCM were found to be 2 ½ times more likely to carry a rare variant in a relevant DCM gene compared to those with less severe heart disease.
👉This discovery provides additional insights for healthcare professionals to better assess the risk of outcomes in managing DCM patients and identifying at-risk family members.
We at 4bases take pride in offering healthcare providers CARDIO pro, a kit utilizing Next Generation Sequencing Technologies for the genetic profiling of familial cardiovascular diseases.
#DCM #genetictesting #CARDIOpro #NGS #4bases
Sources:
Mark Hofmeyer, Garrie Haas, Jinwen Cao, Evan Kransdorf, Ewald, G. A., Alanna Morris, Anjali Owens, A. T., Brian Lowes, D. Stoller, D., Tang, W. W., Garg, S., Barry Trachtenberg, Salpy Pamboukian, S. V., Nancy Sweitzer, Wheeler, M. T., Wilcox, J. E., Katz, S. D., Hershberger, R. E. (2023b).
Rare variant genetics and dilated cardiomyopathy severity : The DCM Precision Medicine Study. Circulation, 148(11), 872‑881.
https://lnkd.in/eVctyPa9
Study shows benefit of routine genetic testing of dilated cardiomyopathy patients with advanced heart disease.
The Ohio State University Wexner Medical Center.
https://lnkd.in/ecAhAXmn
Biochemist researcher, Physical sciences Teacher
1moWonderful. This gives me a feeling of "living in the future". 😮