Blue Matter’s Post

Just a reminder from Miller's insights: IV NaHCO3, vital in emergencies, reveals its nuances in broader clinical contexts, underlining the delicate balance of acid-base equilibrium, potential complications, and optimal dosing. #Medicine #AcidBaseBalance #criticalcare IV NaHCO3 Use: ✔ Reserved for emergency treatment of specific conditions: severe hyperkalemia, arrhythmias from tricyclic antidepressant overdose. ✔ Limited clinical benefit in many situations, emphasizing an important pathophysiologic concept. ✔ Acidosis may not be inherently harmful; normal during strenuous exercise, potentially indicating underlying disease severity. Negative Effects of HCO3− Administration: 1- Carbon Dioxide Production: 👉 HCO3− converted to CO2, leading to excess CO2 requiring excretion. 👉 Excess CO2 may pose a challenge for critically ill patients, potentially aggravating intracellular acidosis. 2- Osmotic Load and Sodium Content: 👉 IV HCO3− introduces significant Na+ content, causing osmotic load. 👉 Potential consequences: hyperosmolar hypernatremia, extracellular fluid (ECF) expansion, and volume overload. 3- Risk of Metabolic Alkalosis: 👉 Impaired renal HCO3− distribution may result in a "overshoot" toward metabolic alkalosis after resolving the initial acidosis. Dosing Considerations: 👉 Total dose calculation for HCO3− administration: Dose(mEq) = 0.3 × weight(kg) × base deficit(mEq/L). 👉 Typically, half the calculated dose is administered (because of the problems outlined above) 👉 Treatment should cease once pH rises above 7.2 due to the outlined problems.

A painful rare disease where calcium builds up in the arteries could be treated with an obvious drug that had been overlooked for years. Etidronate, a drug that reduces calcium absorption, is used in various bone diseases. Given this rare disease (ACDC) has an excessive calcium issue, it seems obvious that etidronate would be a perfect fit. But because it's a cheap, old drug, with no financial incentives, no one took the initiative to repurpose it. Recently, an amazing team at the NIH decided to pick it up and conduct a clinical trial. The results look really promising. At Every Cure, we see this as an example of low-hanging fruit: we understand the disease, we understand the drug, and there's a perfect match between them. However, no one is pursuing these opportunities because there's no profit to be made. This is where Every Cure steps in, identifying such opportunities and moving them forward. #DrugRepurposing #HealthcareInnovation #RareDiseases #MedicalBreakthroughs #PatientCares

Coagulation analyzers and reagents have a significant role to play in the timely detection of bleeding disorders. These meticulously assess coagulation factors to ensure the precise and expeditious identification of such disorders. Transasia Bio-Medicals offers advanced solutions, such as D-dimer assays and the ECL range of coagulation analyzers, including ECL 760, ECL 412 and ECL 105, for the timely diagnosis of various types of coagulation disorders. Learn more on https://zurl.co/cYrL & https://zurl.co/UFWQ or reach out to us on 7304448818. Let us collectively champion advancements in diagnostics, making a substantial impact on patient outcomes. Your commitment to healthcare excellence starts with embracing cutting-edge solutions. #BleedingDisordersAwarenessMonth #BleedingDisorders #IAmTransasia #WeAreErba #CoagulationAnalyzers #HealthcareInnovation #EarlyDetection #LabMedicine #coagulation

Happy to share our last collaborative effort published on JBRHA (IF: 3.2). Our work gathers, analyzes, and discusses the current literature concerning the Impact of Exosomes on Diabetes and Diabetes-associated complications  #exosomes #diabetes #diabetesresearch #sciences #medicalaboratorysciences #diabetescomplications https://lnkd.in/dVRUtMnx

Coagulation analyzers and reagents have a significant role to play in the timely detection of bleeding disorders. These meticulously assess coagulation factors to ensure the precise and expeditious identification of such disorders. Transasia Bio-Medicals offers advanced solutions, such as D-dimer assays and the ECL range of coagulation analyzers, including ECL 760, ECL 412 and ECL 105, for the timely diagnosis of various types of coagulation disorders. Learn more on https://zurl.co/cYrL & https://zurl.co/UFWQ or reach out to us on 7304448818. Let us collectively champion advancements in diagnostics, making a substantial impact on patient outcomes. Your commitment to healthcare excellence starts with embracing cutting-edge solutions. #BleedingDisordersAwarenessMonth #BleedingDisorders #IAmTransasia #WeAreErba #CoagulationAnalyzers #HealthcareInnovation #EarlyDetection #LabMedicine #coagulation

In a trial of nearly 600 patients with hypertension, a four-drug, single-pill combination (that contained small doses of irbesartan, indapamide, amlodipine, and bisoprolol) lowered 24-hour systolic blood pressure more than full-dose irbesartan and led to higher rates of control. The incidence of adverse effects was similar between groups. While promising, clinical experience with using four-drug combination pills is limited and therefore not yet recommended as initial treatment. Explore What's New in #hypertension: https://ow.ly/6zzm50Snm3T #ClinicalUpdates #meded

This study looks at the development of an interactive, non-invasive #ArtificialIntelligence system to predict malignancy risk in cystic renal lesions. (Quan-Hao He et al.) #InsightsIntoImaging #DeepLearning 🔗 https://buff.ly/4bRCdea

Progression of Coronary Artery Calcification and Risk of Clinical Events in #CKD: The Chronic Renal Insufficiency Cohort Study | https://ow.ly/jEBe50Tfvxv #kidney #kidneydisease #fridayreads #weekendreads

Did you ever think about what is physically happening in our bodies as we age? Aging is not necessarily a chronological thing that can be measured in years. It entails such changes as DNA damage, telomere shortening, mitochondrial dysfunction and cellular senescence. These are the roots behind the changes we see on the outside: greying hair, weakening muscles, sagging skin, forgetfulness and disease. Today disease too is affecting people at an alarming rate. The evidence is the number of pharmaceutical ads on American TV – there have to be a lot of sufferers out there to make the cost of a TV ad worthwhile! Scientists are learning a lot about these changes and a little about how to slow them. Are you keeping up?