BioCentury Inc.’s Post

I’m thrilled to announce the publication of my review article, "A Comprehensive Review on Repurposing the Nanocarriers for the Treatment of Parkinson’s Disease: An Updated Patent and Clinical Trials" in the prestigious journal CNS & Neurological Disorders - Drug Targets by Bentham Science (Impact Factor: 2.7). This review explores the repurposing of nanocarriers for Parkinson’s Disease (PD) treatment, focusing on their potential to address key pathological pathways. It also highlights recent advancements in nanotechnology and provides an updated analysis of patents and clinical trials that showcase innovative approaches to improving PD therapy. I would like to extend my heartfelt gratitude to Dr. Md. Faheem Haider Sir for his invaluable mentorship and unwavering support to shape this article. Looking forward to contributing further to the advancement of neurodegenerative diseases. #Nanotechnology #ParkinsonsDisease #DrugDelivery #Pathways #Research #Neuroscience #Mentorship #Science

Discover the latest in Alzheimer's research from professors Blaine Roberts, PhD and Andy Liu, MD, MS. 🥼 Dr. Roberts is an Associate Professor at Emory University, specializes in Biochemistry and Neurology. Focusing on neurodegenerative diseases, including Alzheimer's, Parkinson's, and ALS, Dr. Roberts obtained his Ph.D. in biochemistry & biophysics from Oregon State University. His lab utilizes advanced mass spectrometry and ELISA-based technologies to pinpoint and validate disease biomarkers in CSF and blood. 🥼 Dr. Liu is an Assistant Professor in Neurology and Pathology at Duke University. As the Director of Biomarker Discovery in the Department of Neurology, Dr. Liu specializes in evaluating cognitive changes in aging patients and establishing fluid biomarkers for various neurodegenerative conditions. Dr. Liu is dedicated to investigating racial disparities in Alzheimer’s disease among underrepresented minorities. Watch the full on-demand webinar to see Dr. Roberts and Dr. Liu discuss the research at forefront of AD diagnostics. https://bit.ly/3ykGbNT #Alzheimers #Webinar #Research

The California Institute for Regenerative Medicine (CIRM) has awarded over $28M in funding to Lipton Stuart, MD, PhD, and Xin Jin, PhD, to advance critical research on neuropsychiatric disorders. Lipton’s team will leverage $17.5M to investigate how air pollution— from vehicle exhaust, tobacco smoke, and wildfires—can disrupt brain proteins via S-nitrosylation, a chemical reaction that may contribute to autism and intellectual disabilities. Jin’s team, in collaboration with the Salk Institute and UC San Diego, received $11M to study risk genes in psychiatric disorders, using state-of-the-art functional genomic analysis to seek mechanisms and design therapeutic agents addressing these disorders. This large-team, collaborative research, part of CIRM’s ReMIND-L initiative, seeks to identify novel biomarkers and therapeutic targets, unlocking new translational and clinical potential in regenerative medicine. More at: https://ow.ly/vht150TN8OU

Industry’s focus on specific diseases shifts with the commercial landscape, while academic labs uncover new disease biology. With inflammation and neuroscience gaining interest, research labs provide new targets and strategies. At #BioCenturyGrandRounds, The Disease Biology Boom Session will show how emerging science can better prepare drug developers: ➤ Unlocking progress in neurology: How to build the case for a new target ➤ Immunity and inflammation inflection point: What determines the direction from here? Speakers in this session include: ➤ Jamil M. Beg, SV Health Investors ➤ Gwendolyn Binder PhD, Cabaletta Bio ➤ Aaron Esser-Kahn, University of Chicago ➤ Daniel Reich, NIH Clinical Center (CC) ➤ Jill C Richardson FRSB, MSD ➤ Adam Savitz, Alto Neuroscience ➤ Samantha Singer, Abata Therapeutics ➤ Paul Peter Tak, MD PhD FMedSci, Candel Therapeutics ➤ And more... Download the conference brochure to view the full agenda: https://lnkd.in/gtP_xdri Register and learn more at https://lnkd.in/gmhZ75vm. #diseases #biology #inflammation #neuroscience

📃Scientific paper: Perivascular macrophages in the CNS: From health to neurovascular diseases Abstract: Brain perivascular macrophages (PVMs) are attracting increasing attention as this emerging cell population in the brain has multifaced roles in supporting the central nervous system structure, brain development, and maintaining physiological functions. They also widely participate in neurological diseases such as neurodegeneration and ischemic stroke. Moreover, PVMs have been reported to have both beneficial and detrimental effects under different pathological contexts. Advanced research technologies allowed the further in‐depth study of PVMs and revealed novel concepts in their origins, differentiation, and regulatory mechanisms. Deepened understanding of the roles of PVMs in different brain pathological conditions can reveal novel phenotypic changes and regulatory signaling, which might pave the way for the development of novel treatment strategies targeting PVMs. Continued on ES/IODE ➡️ https://etcse.fr/jtLE1 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

🔬Exciting Insights on Leigh Syndrome: Delving into the work of seven decades by Dr. Asuri N Prasad! I had the privilege of attending a talk on Leigh Syndrome at the Department of Biochemistry, KMC, Manipal, and it was a wonderful session! Leigh Syndrome is a rare and complex neurodegenerative disorder that poses significant challenges in diagnosis and treatment. It is caused by abnormalities in mitochondrial energy generation. Key Highlights: 🧬 Understanding the Genetic Basis: Unraveling the genetic underpinnings of Leigh Syndrome is crucial for targeted therapies. We explored the latest advancements in genetic research and their implications for personalized treatment approaches. 💡 Diagnostic Innovations: Timely and accurate diagnosis is pivotal for effective management. We discussed diagnostic technologies that are revolutionizing the identification of Leigh Syndrome, enhancing the ability to intervene early. 🌐 Collaborative Efforts: Addressing Leigh Syndrome requires a multidisciplinary approach with the collaboration of researchers, clinicians, and industry professionals. 🔗 Connecting the Dots: Leigh Syndrome is a puzzle, and every piece of knowledge contributes to solving it. We connected the dots between clinical observations, research findings, and patient statistics to foster a holistic understanding of the syndrome. #LeighSyndrome #Neurology #Research #HealthcareInnovation #Genomics #Collaboration #rarediseases

📃Scientific paper: Perivascular macrophages in the CNS: From health to neurovascular diseases Abstract: Brain perivascular macrophages (PVMs) are attracting increasing attention as this emerging cell population in the brain has multifaced roles in supporting the central nervous system structure, brain development, and maintaining physiological functions. They also widely participate in neurological diseases such as neurodegeneration and ischemic stroke. Moreover, PVMs have been reported to have both beneficial and detrimental effects under different pathological contexts. Advanced research technologies allowed the further in‐depth study of PVMs and revealed novel concepts in their origins, differentiation, and regulatory mechanisms. Deepened understanding of the roles of PVMs in different brain pathological conditions can reveal novel phenotypic changes and regulatory signaling, which might pave the way for the development of novel treatment strategies targeting PVMs. Continued on ES/IODE ➡️ https://etcse.fr/jtLE1 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

My PhD thesis work was published in Neuron today! My research explores the impact of Alzheimer's risk factors APOE4 and TREM2-R47H in a tauopathy mouse model, revealing elevated microglial cGAS-STING signaling and senescence in females with both risk factors. https://lnkd.in/eeQYe7Ae

Researchers Nicholas Sweeney, Tae Yeon Kim, Cody Morrison, et al. have found that #TraumaticBrainInjury (#TBI) increases the risk of #AlzheimersDisease by disrupting protein clearance, leading to the accumulation of toxic tau proteins in the brain. They discovered that TBI downregulates BAG3, a protein crucial for clearing damaged proteins, which contributes to #Alzheimers-related tau buildup. Overexpression of BAG3 in mouse models reduced tau accumulation and improved cognitive function, suggesting a potential therapeutic target. These findings provide new insight into the biological link between TBI and Alzheimer’s, opening avenues for developing therapies that could reduce Alzheimer’s risk after TBI. Learn More in Acta Neuropathologica | Pathology and Mechanisms of Neurological Disease https://lnkd.in/dsFAiXp9 Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy‑lysosome pathway - Nicholas Sweeney, Tae Yeon Kim, Cody Morrison, Gail VW Johnson, HONGJUN (Harry) FU, et al. The Ohio State University The Ohio State University College of Medicine WVU Rockefeller Neuroscience Institute Banner Sun Health Research Institute RIKEN Center for Brain Science Nagoya City University University of Rochester

SIPS 2023 Impressions: « A very interesting approach that breaks boundaries in science and … society. I enjoyed it very much » https://lnkd.in/dE9hUUCh Dr. Eugenia Trushina, Mayo Clinic, USA, is an expert in a range of neurodegenerative diseases. She is principal investigator of the Mitochondrial Neurobiology and Therapeutics Lab and a professor of neurology and pharmacology at Mayo Clinic College of Medicine and Science in Rochester. Her research goal is to find better treatments for a variety of neurodegenerative diseases that currently have limited options. Her research in the Mitochondrial Neurobiology and Therapeutics Laboratory focuses on understanding the early molecular mechanisms of these diseases, with a special emphasis on the contributing role of altered mitochondrial dynamics and function. This work has great potential benefit for people with Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and metabolic disorders. Studies in her lab provide a foundation for the development of disease-modifying mitochondria-targeted interventions. FLOGEN SIPS 2023 ( https://lnkd.in/djw3UjjK ) held in Hyatt's Dreams Playa Bonita Resort in Panama from 27 Nov. to 1 Dec. 2023 with the participation of numerous Nobel Laureates and many Distinguished Guests. It features about 50 scientific and technology symposia covering various distinguished fields. Academics, Engineers, Managers, Directors, CEOs, Medical Doctors, Lawyers, Economists and Politicians will be in attendance. A visit to Panama Canal was included in the program. SIPS ( Sustainability Through Science and Technology Summit / Sustainable Industrial Processing Summit is held annually since 2003 in various countries around the world: https://lnkd.in/ddUfH6J4 #sips2023 #flogensips #flogen #panama #flogensips2023 #playabonitapanama #dreamsplayabonita Eugenia (Jania) Trushina #science #technology #sustainability