BioCentury Inc.’s Post

Hello #SLAS2024 Boston! Make sure to join our team bright and early tomorrow morning at 8.30 am for freshly baked muffins, English scones and coffee during our panel discussion titled “Functional genomics for target identification: What has been achieved, what are the current challenges and what are the future opportunities”? Grab your refreshments and learn about: - The vital role of functional genomics in early drug discovery, especially in the use of both pooled and arrayed CRISPR knockout screens - The need for predictive models in target identification, challenges in different fields like oncology and neuroscience, and the trade-offs in using different cell models for CRISPR screening. - New techniques to improve CRISPR screening outcomes and innovative strategies beyond traditional loss-of-function approaches to identify effective targets for disease research and drug discovery. Register now: https://hubs.ly/Q02jn_fT0 #research #DrugDiscovery #ScienceCommunication #optiox #ioCells #iPSC #neuroscience #CRISPR #screens #GenomeEditing #GeneEditing #HTS #neuron #array

New algorithm alert. A team of researchers at Insilico Medicine just published on the feasibility of using a new algorithm called Quantum-assisted Fragment-based Automated Structure Generator (QFASG) in automated drug design. ◾ QFASG utilizes advanced chemoinformatic techniques to construct novel small-molecule structures from a library of molecular fragments. ◾ The algorithm employs a two-part approach: first, probes are strategically placed within target binding sites, and then structural growth occurs through iterative modules, resulting in the generation of diverse compound libraries. ◾ To demonstrate its effectiveness, the researchers successfully applied QFASG to generate new small-molecule inhibitors of two pharmacological targets involved in cancer pathogenesis -- ATM and CAMKK2 kinases. The findings were published in Frontiers in Chemistry. *Link to release in comments #ai #genai #algorithm #chemistry #medchem #cancer #quantum Alex Zhavoronkov Sergei Evteev Ivan Semenov Alex Aliper

Research Supplier Product Show TOMORROW! Thursday, April 25, 2024 | 11:00AM - 1:30PM For Researchers at: The Rockefeller University | Weill Cornell Medicine | Memorial Sloan Kettering Cancer Center If you are interested in exhibiting at or registering to attend this event, direct message us or email [email protected] . . . #science #scientificresearch #labwarriors #laboratory #biology #chemistry #lsevendorshows #lifescienceexhibits2024 #scientificvendorshows #research #lseshows #lablife

We're glad you found our educational resources helpful! Our eBooks, guides, videos, protocols, and blog posts can all be found accessed through our educational resources page: https://lnkd.in/esyKxQH4 And if you ever have a suggestion for a topic you'd like to see us cover, please let us know!

👂🏻 He changed thousands of lives with the cochlear implant. Emeritus Prof Graeme Clark AC has now helped two more, with the donation of his 2023 Rehabilitation International Centenary Prize to support scholarships for PhD students Kirill Kokorin and Satheesh Kumar. Working with leading experts in the Graeme Clark Institute for Biomedical Engineering, Kokorin and Kumar are researching brain-computer inferfaces (BCIs) and gene editing for Usher Syndrome respectively. The results could improve the lives of people with incurable conditions, as Prof Clark did. Learn more → unimelb.me/4aYCL16

📢Keynote announcement We are thrilled to announce that Dr. Illana Gozes, Director, Elton Lab. for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry Tel Aviv University, will be #keynotespeaker at our upcoming 6th Cell and Experimental Biology Conference (CEB-2025) scheduled during 𝗔𝗽𝗿𝗶𝗹 𝟮𝟯-𝟮𝟱, 𝟮𝟬𝟮𝟱, in 𝗗𝗼𝘂𝗯𝗹𝗲𝗧𝗿𝗲𝗲 𝗯𝘆 𝗛𝗶𝗹𝘁𝗼𝗻, Houston, TX. Dr. Illana Gozes is an internationally well-known pioneer in molecular neuroscience and neuroprotective drug discovery. She discovered novel proteins crucial for brain development and aging and invented a new protective drug candidate for the treatment of Alzheimer`s disease and related neurodegenerative disorders. 🎙️: 𝘚𝘦𝘹-𝘥𝘦𝘱𝘦𝘯𝘥𝘦𝘯𝘵 𝘉𝘳𝘢𝘪𝘯 𝘍𝘰𝘳𝘮𝘢𝘵𝘪𝘰𝘯 𝘢𝘯𝘥 𝘍𝘶𝘯𝘤𝘵𝘪𝘰𝘯: 𝘈𝘋𝘕𝘗 𝘢𝘯𝘥 𝘵𝘩𝘦 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘋𝘳𝘶𝘨, 𝘋𝘢𝘷𝘶𝘯𝘦𝘵𝘪𝘥𝘦 𝘢𝘴 𝘢𝘯 𝘌𝘴𝘴𝘦𝘯𝘵𝘪𝘢𝘭 𝘊𝘢𝘴𝘦 𝘚𝘵𝘶𝘥𝘺 🤝Join us as the conference will feature a diverse array of scientific sessions, workshops, and panel discussions covering various topics related to #biochemistry, #cellmolecularbiology, #cellanddevelopmentalbiology, #cancerbiology, #pharmacology and #physiology. 🔔Stay tuned for further updates regarding the conference agenda and additional speakers. For more information, please visit our conference website or follow us on LinkedIn to receive the latest news and insights. Website: https://lnkd.in/d3mDbDyi Contact us: [email protected] #ceb2025 #cellbiology #Developmentalbiology #oncology #genetics #houston #texas #events #conference #keynotes #oralpresentation #cell #rna #dna #mrna #nucliecacids #autophagy #biochemistry #pharma #drug #lifescience #neuro #biology

Join us for the inaugural Stanford Cancer Institute Advances in Mass Spectrometry Enabled Drug Discovery symposium. On October 29, 2024, leading experts in academia and industry will come together to explore current challenges and opportunities, as well as recent achievements across diverse applications in drug development.  This field has revolutionized ligand and target discovery by enabling the detection of interactions proteome-wide. Chemoproteomic techniques targeting reactive residues have grown and expanded the scope of covalent ligand discovery. Mass spectrometry instrumentation continues to improve, deepening proteomic coverage, accuracy, and sensitivity while becoming more accessible. The symposium is open to Stanford faculty, students, and postgraduates, as well as those outside of Stanford who are interested in diving into the cutting-edge world of proteomics. Join us for this all-day dynamic learning experience to discuss the exciting progress in mass spectrometry-based proteomics. Early bird registration is available now. https://stan.md/3WYqJRP #DrugDiscovery #MassSpectrometry #StanfordCancer #proteomics

Join us for the inaugural Stanford Cancer Institute Advances in Mass Spectrometry Enabled Drug Discovery symposium. On October 29, 2024, leading experts in academia and industry will come together to explore current challenges and opportunities, as well as recent achievements across diverse applications in drug development. This field has revolutionized ligand and target discovery by enabling the detection of interactions proteome-wide. Chemoproteomic techniques targeting reactive residues have grown and expanded the scope of covalent ligand discovery. Mass spectrometry instrumentation continues to improve, deepening proteomic coverage, accuracy, and sensitivity while becoming more accessible. The symposium is open to Stanford faculty, students, and postgraduates, as well as those outside of Stanford who are interested in diving into the cutting-edge world of proteomics. Join us for this all-day dynamic learning experience to discuss the exciting progress in mass spectrometry-based proteomics. Early bird registration is still available. short.url/aBcXyZ #DrugDiscovery #MassSpectrometry #StanfordCancer #proteomics Stanford University School of Medicine

Very happy to see a recent article in Cell Reports Medicine highlighting De novo GTP synthesis inhibition as a viable strategy for intercepting brain metastases! Our group has done some pioneering work in identifying moderately potent human inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors few years ago! Our work is cited in this article! The interesting part is that the article emphasizes and endorses IMPDH as a relevant target for attenuating brain metastasis outgrowth, which may provide an alternative treatment strategy for patients who are otherwise limited to palliation. Thank you Sheila Singh and group for this amazing piece of work! Hope the research gets translated to the clinic soon! Thanks to previous PhD students from group Niteshkumar Sahu Dr. Chetan Shah, Ph.D. and my collaborators Sivapriya Kirubakaran Kapil Juvale! #cancer #research #cscs #biology #chemistry #medicinalchemistry #IMPDH #brain #GBM #metastasis #biotechnology #drugdiscovery #drugdevelopment

With our in-air microfluidics technology being developed with stem cell application as a target, we will contribute to solving key challenges in cell therapy manufacturing and scaling. #cell therapy #microfluidics #iamfluidics