New from Cell Chemical Biology: Arc Core Investigator and Stanford University Biochem Professor Lingyin Li explores the future of cancer therapy using cGAMP-STING 🧬 The Li lab works to investigate how the signaling molecule cGAMP is passed between different cell types to activate the STING pathway and how cancers escape detection through cGAMP degradation — which controls how immune cells are recruited to a tumor to fight cancer. The perspective piece from Dr. Li outlines the successes + setbacks of cGAMP analogs as STING agonists, as well as new strategies for boosting endogenous cGAMP-STING signaling for cancer therapy while avoiding toxic side effects.👇 https://lnkd.in/gaaD2ZME
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What is the link between senescence — a cellular state during which cells stop dividing — and cancer? By studying their complex relationship, researchers are uncovering both positive and negative outcomes associated with senescent cells. In our new blog post covering applications of #proteomics in cancer research, we discuss work from Scott Lowe's lab at Memorial Sloan Kettering Cancer Center showing how senescent cells can interact with the immune system to promote tumor clearance. Check it out to learn about these key interactions and how they might be leveraged to develop more effective cancer therapies. https://ow.ly/gRtu50SCyvk #UnleashTheProteome #ProteomicsRevolution #SingleMolecule #MassSpec #TeamMassSpec #Biotech #Cancer
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The relationship between #cancer and senescence is complex, but #proteomics work like this could enable us to leverage it to better treat malignancy. Thanks to Jennifer Tsang, Ph.D. for help with this post!
What is the link between senescence — a cellular state during which cells stop dividing — and cancer? By studying their complex relationship, researchers are uncovering both positive and negative outcomes associated with senescent cells. In our new blog post covering applications of #proteomics in cancer research, we discuss work from Scott Lowe's lab at Memorial Sloan Kettering Cancer Center showing how senescent cells can interact with the immune system to promote tumor clearance. Check it out to learn about these key interactions and how they might be leveraged to develop more effective cancer therapies. https://ow.ly/gRtu50SCyvk #UnleashTheProteome #ProteomicsRevolution #SingleMolecule #MassSpec #TeamMassSpec #Biotech #Cancer
Applications of proteomics in cancer - Exploring the relationship between senescence and tumor clearance
https://www.nautilus.bio
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Ahlina Archibald is a postbaccalaureate research fellow in the National Institutes of Health (NIH): Intramural Research Program (IRP) who studies how molecular gardeners called ribonucleases trim overgrown RNA molecules that contribute to cancer. Figuring out which RNA molecules those ribonucleases remove could reveal new targets for cancer therapies. Watch this video to learn how these molecular gardeners can curtail colorectal cancer.
Scibites-Alhina-Captions-June.mp4
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Medicinal Chemistry - Project Leader; Technology Innovation & External Platforms presso Alfasigma - parla di #scienze #farmaci #farmaceutico #ricerca #innovazione #sociale
HYPOXY: INTRIGUING FEATURE IN CANCER CELL BIOLOGY Hypoxia, a key aspect of the tumor microenvironment, plays a vital role in cell proliferation, angiogenesis, metabolism, and the immune response within tumors. These factors collectively promote tumor advancement, aggressiveness, metastasis and result in a poor prognosis. Hypoxia inducible factor 1α (HIF-1α), activated under low oxygen conditions, mediates many of these effects by altering drug target expression, metabolic regulation, and oxygen consumption. These changes promote cancer cell growth and survival. Hypoxic tumor cells develop aggressive traits and resistance to chemotherapy and radiotherapy, leading to increased mortality. Targeting hypoxic tumor offers a potential solution to overcome the challenges posed by tumor heterogeneity and can be used in designing diagnostic and therapeutic nanocarriers for various solid cancers. This concept provides an overview of the intricate relationship between hypoxia and the tumor microenvironment, highlighting its potential as a promising tool for cancer therapies. The article explores the development of hypoxia in cancer cells and its role in cancer progression, along with the latest advancements in hypoxia-triggered cancer treatment. #Hypoxia_Inducible_Factor_1α #HIF_1α #cancer #therapy #tumor_microenvironment
Full professor of Medicinal Chemistry & Chemical Biology at the University of Salerno; Secretary of the EFMC Executive Committee; Chair of the Editorial Board of ChemMedChem
Hypoxia, a key aspect of the tumor microenvironment, plays a vital role in cell proliferation, angiogenesis, metabolism, and the immune response within tumors. A concept published in ChemMedChem (Chemistry Europe) as Early View Article delves into the intricacies of how hypoxia develops within cancer cells and its pivotal role in driving cancer progression, while also shedding light on the breakthroughs in hypoxia-induced cancer treatments. Hypoxia: Intriguing Feature in Cancer Cell Biology Monalisa Chowdhury, Prasanta Kumar Das (Indian Association for the Cultivation of Science) https://lnkd.in/dv6cMCCa
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Special RNA suppresses the formation of breast cancer cells. A team of researchers from Friedrich Schiller University Jena, the University in Shenzhen, and Jena University Hospital has uncovered a molecular mechanism involving a long non-coding RNA, PAPAS, that suppresses the formation of breast cancer cells. The study revealed that PAPAS influences access to active regions of DNA, reducing ribosomal RNA (rRNA) production. High PAPAS levels were associated with low tumor growth, suggesting a potential for diagnostic and treatment methods for breast cancer based on these findings. Read more: https://lnkd.in/dqvKx3yt #rna #oncology #breastcancer #medical #biology
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🧬 Delve into the future of cancer detection with our latest blog post on Cell-free DNA Fragmentomics. 🧬 Analyzing the unique fragmentation patterns of cfDNA is a versatile and promising direction for early cancer detection from a non-invasive blood sample. By exploiting the unique properties of cfDNA fragmentation, researchers can gain a fuller picture of disease presence and integrate this knowledge with other omics fields, such as epigenomics and transcriptomics. Discover how fragmentomics could revolutionize cancer screening: https://bit.ly/46qqktV! #ClinomicsEurope #ClinomicsDiagnostics #LiquidBiopsy #CancerResearch #cfDNA #Fragmentomics #MedicalAdvancements
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“We examined both tumor biopsies and blood samples with advanced laboratory techniques. Via machine learning, we combined gene expression in the tumor with hereditary characteristics of the patients' immune system, more specifically the HLA genes, which come in hundreds of variations depending on the individual. "This approach allowed us to find a 'molecular signature' that showed a clear association with clinical response and survival rates. We further confirmed this association on independent samples from more than 1,000 kidney cancer patients from other international studies." The lab analyses further showed that a successful response to immunotherapy was tied to a good interaction between two types of immune cells, namely CD8+ T cells and macrophages.” #kidneycancer #cancerresearch #immunotherapy #immunesystem #cancer
New biomarker predicts success of immunotherapy in kidney cancer — Medical Xpress
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Biomedical Scientist | Cancer Immunotherapy | Looking for a new challenge in Project Management/RA/Consulting
Today I would like to highlight Rho GTPases in Cancer. These tiny cellular switches play a pivotal role in orchestrating cell movement, shape, and communication. In the world of cancer biology, Rho GTPases have become intriguing characters, influencing processes like cell migration and invasion—crucial in the progression of many cancers. Unravelling their intricacies provides a deeper understanding of the molecular mechanisms behind tumorigenesis. Yet, like complex characters in a scientific drama, Rho GTPases can have dual roles. While some members promote cancer progression, others exhibit tumour-suppressive qualities. Navigating this intricate balance unveils potential avenues for therapeutic interventions. #CancerBiology #RhoGTPases
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Did you miss our webinar outlining how spatial transcriptomics can enhance your understanding of cancer biology and therapeutic responses? No problem it’s available on-demand! Reveal new dimensions in cancer research with our latest insights into spatial transcriptomics and tumor cell cluster evaluation. Discover how analyzing tumor cell clusters with spatial transcriptomics is providing critical information about tumor microenvironments and cellular interactions, paving the way for advanced therapeutic strategies. Listen to the short clip for an overview, and dive into the full content to explore how these innovations are shaping the future of oncology. Watch the webinar now➡️ https://hubs.la/Q02J3zzk0 #Biomarkers #SpatialTranscriptomics #CancerResearch #DrugDiscovery #PersonalizedMedicine
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In case you missed it: How spatial transcriptomics can enhance your understanding of cancer biology and therapeutic response
Did you miss our webinar outlining how spatial transcriptomics can enhance your understanding of cancer biology and therapeutic responses? No problem it’s available on-demand! Reveal new dimensions in cancer research with our latest insights into spatial transcriptomics and tumor cell cluster evaluation. Discover how analyzing tumor cell clusters with spatial transcriptomics is providing critical information about tumor microenvironments and cellular interactions, paving the way for advanced therapeutic strategies. Listen to the short clip for an overview, and dive into the full content to explore how these innovations are shaping the future of oncology. Watch the webinar now➡️ https://hubs.la/Q02J3zzk0 #Biomarkers #SpatialTranscriptomics #CancerResearch #DrugDiscovery #PersonalizedMedicine
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Remarkable story of impact, Lingyin Li!