🎧 Exciting new discovery from Lingyin Li and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to threats like viral and bacterial infections and cancer. But how does it know when to fight and when to stand down? Lingyin and Chris found that PELI2 acts like a sensor, filtering out cellular “white noise” that could chronically trigger STING—and lead to inflammatory conditions like lupus and neurodegeneration. At the same time, PELI2 turns into an amplifier when interferon levels grow above a certain threshold, ensuring that STING turns on at the right time. As Lingyin explains, “This research was highly interdisciplinary, combining “hardcore” biochemistry with immunology, genetics, and computation, but likely would not have received funding under traditional models. It’s the kind of curiosity-driven, interdisciplinary work that we’re uniquely positioned to do at Arc.” Read the full study in MolecularCell: https://lnkd.in/gmj6VDHK
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🧬🔍 Discovering Cretan HLA Genetics: This is our new ASHI Insights article! New research in Human Immunology reveals fascinating connections between Crete's Minoan culture and North Africa & Europe. Dive into the findings! https://lnkd.in/gigENK3m #ASHIInsights
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Immunoproteomics upstage genomics in I&I target discovery: BioCentury's Back to School 2024 identifies the target classes emerging in inflammation and immunology, and the technologies used to find them
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Creativity is as important as knowledge / Director, Ph.D. Program in Sciences and Innovation in Medicine at Universidad del Desarrollo
Synpoptosis: A synthetic biology approach to programmable cell death Cells naturally die (apoptosis, pyroptosis) to eliminate harmful cells and regulate inflammation. Synthetic protein circuits could trigger specific cell death programs in targeted cells, offering a way to eliminate harmful cells while managing immune responses. However, controlling cell death is challenging because cells respond to natural signals. This research introduces "synpoptosis" circuits, inspired by nature, that use protein breakdown to control engineered executioner proteins and mammalian cell death. These circuits direct death modes, respond to protease signals, and eliminate target cells selectively. Additionally, they can be transmitted between cells, enabling the engineering of synthetic killer cells that induce desired death programs without self-destruction. This paves the way for programmable control of mammalian cell death, which has promising applications in cancer and immune disease. The original article was published in Cell: https://lnkd.in/eKm8aScv. #genetics #genomics #precisionmedicine #genomicmedicine #syntheticbiology #apoptosis #celldeath #bioengineering #molecularbiology #biotechnology #cancer #inflammation #immunity #immunology #mitosis #proliferation #therapeutics #innovation #research #science #sciencecommunication
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Phagocytosis involves several sequential stages👇 📎Phagocytes such as macrophages and neutrophils employ pattern-recognition receptors to directly bind to microbes or those coated with complement proteins. 📎This initiates the internalization of the microbes, encapsulating them within phagosome vesicles within the cell's cytosol. Subsequently, these phagosomes merge with lysosomes, exposing the microbes to potent chemicals like ROS and NO, as well as proteolytic enzymes. 📎This process effectively eradicates and breaks down the microbes, ensuring their destruction Image from: Carsten Carlberg, Eunike Velleuer - Molecular Immunology_ How Science Works-Springer (2022) #phagocytosis #microbes #cancerbiology #cancerbiologyresearch
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🌟 Weekly Science & Research Update 🌟 Welcome to this week’s roundup of groundbreaking discoveries and innovations in the world of science! Let’s dive into the latest research that is pushing the boundaries of our understanding. Visit these links to know more: Genomics Innovation 🧬 Researchers have achieved de novo scaffolding of chromosome-level haplotypes using Hi-C data to construct the genome of Miscanthus × giganteus. This advancement could enhance biofuel production and genetic research. ( https://lnkd.in/gvNK55qU) Glioma Research 🧠 CCL2-mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through the CD84-SHP2 pathway. This finding offers new insights into glioma progression and potential therapeutic targets. (https://lnkd.in/guyY7Htd) Cancer Research 🧬 A CRISPR-based study has dissected the functionality of the microRNA-23a ~ 27a ~ 24-2 cluster in hepatocellular carcinoma, providing new avenues for cancer treatment. (https://lnkd.in/ghaCB_Pi) Plant Pathology 🌱 Scientists have isolated and analyzed the genome of Ceratobasidium theobromae, a new pathogen of cassava in Southeast Asia. Understanding its tissue localization could help in developing strategies to protect this vital crop. (https://lnkd.in/gVx74kh4) Neuroscience Discovery 🧠 Multisensory gamma stimulation has been shown to mitigate the effects of demyelination induced by cuprizone in male mice. This research could lead to new therapies for neurodegenerative diseases. (https://lnkd.in/gS5Jh8EG) Liver Health Breakthrough 🧬 Activation of the pregnane X receptor has been found to protect against cholestatic liver injury by inhibiting hepatocyte pyroptosis. This discovery could lead to new treatments for liver diseases. (https://lnkd.in/gs6Hvpc2) Stay informed and inspired by the latest in research and innovation. 📚✨ #ResearchUpdate #ScientificBreakthroughs #Innovation
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In the 1970s, BD pioneered flow cytometry, one of the most powerful tools for researchers to study cells and better understand changes linked to disease. Since then, BD Biosciences – celebrating 50 years this year – has enabled researchers to unlock new discoveries. Our cutting-edge technologies enable deeper insights that are changing the future of immunology, cell biology, genomic research, cell-based therapies and more. For example, the BD FACSDiscover™ S8 Cell Sorter with BD CellView™ Image Technology empowers scientists to derive new insights that could lead to more effective treatments for some of the world's most prominent diseases. As the future of healthcare research accelerates at rapid speed, we are delivering products that enable our customers to push the boundaries of science and deliver revolutionary advancements and life-changing discoveries. #BDBiosciences #Flowcytometry #medtechinnovation
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🎉 Exciting News in Stem Cell Research from Osaka University’s Research Institute for Microbial Diseases! A big congratulations to the researchers and scientists for their recent findings being published in the American Society for Microbiology’s journal Molecular and Cellular Biology (Taylor & Francis Group): "Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties." 🧬🩸 We're thrilled to have contributed to this incredible #stemcell, #hemotolgoy, and disease research with our molecular cloning and mutagenesis services. Read the research details and join the celebration of scientific excellence: https://lnkd.in/eZAEJRAi We hope that more research like yours will further our understanding of how blood vessels develop during the early stages of organ development. 📚Hirotaka Konishi, Fitriana Nur Rahmawati, Naoki Okamoto, Keigo Akuta, Koichi Inukai, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura 🔬 #precisionmedicine #mutation #mutations #dna #disease #blood #microbes #microbial #microbiology #citations
Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties
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𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠: 𝐀 𝐂𝐨𝐫𝐧𝐞𝐫𝐬𝐭𝐨𝐧𝐞 𝐢𝐧 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 In the review "Notch Signaling: Multifaceted Role in Development and Disease," published in The FEBS Journal, Nalani Sachan and colleagues delve into the intricate workings of the Notch signaling pathway, a critical regulator in cellular fate decisions. The review outlines how this evolutionarily conserved pathway governs an array of developmental processes, from tissue formation to organ development. 𝐃𝐢𝐬𝐬𝐞𝐜𝐭𝐢𝐧𝐠 𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠: 𝐅𝐫𝐨𝐦 𝐄𝐦𝐛𝐫𝐲𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬 𝐭𝐨 𝐂𝐚𝐧𝐜𝐞𝐫 The authors unravel the pathway’s complex mechanisms, explaining how its dysregulation is linked to a spectrum of diseases, including various cancers. They emphasize the pathway's versatility, illustrating how the same signaling cascade is repurposed across different contexts to perform vital roles in both normal development and disease progression. 𝐂𝐡𝐚𝐫𝐭𝐢𝐧𝐠 𝐍𝐞𝐰 𝐓𝐞𝐫𝐫𝐢𝐭𝐨𝐫𝐲: 𝐓𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 The review doesn’t just look back at what has been established but also charts new territory for future research. The authors call for deeper exploration into the pathway’s regulatory mechanisms, urging scientists to address the many unanswered questions surrounding Notch signaling's role in development and disease. This insightful review is a must-read for anyone involved in developmental biology, oncology, and cell signaling research. #DevelopmentalBiology #CellSignaling #CancerResearch #NotchSignaling #BiomedicalScience #MolecularGenetics #ResearchInnovation #FEBSJournal #ScientificReview
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Publications in 2023: 1. Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis Genomics & Informatics 2023; 21(2): e25. https://lnkd.in/g2m842HT Indexing: Scopus; PubMed; PMC Quartile: Q2 Publisher: Korea Genome Organization 2. Recent Update and Drug Target in Molecular and Pharmacological Insights into Autophagy Modulation in Cancer Treatment and Future Progress https://lnkd.in/gP6WTZ-5 Cells 2023, 12(3), 458 IF: 6.0 | CiteScore (Scopus: 9.0) Indexing: Scopus; PubMed; PMC; SCIE; JCR - Q2 (Cell Biology) #oncology #cancerresearch #cancerbiology #cellbiology #bioinformatics #autophagy #phdposition #phdresearch #phdopportunity #phdstudent
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𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠: 𝐀 𝐂𝐨𝐫𝐧𝐞𝐫𝐬𝐭𝐨𝐧𝐞 𝐢𝐧 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 In the review "Notch Signaling: Multifaceted Role in Development and Disease," published in The FEBS Journal, Nalani Sachan and colleagues delve into the intricate workings of the Notch signaling pathway, a critical regulator in cellular fate decisions. The review outlines how this evolutionarily conserved pathway governs an array of developmental processes, from tissue formation to organ development. 𝐃𝐢𝐬𝐬𝐞𝐜𝐭𝐢𝐧𝐠 𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠: 𝐅𝐫𝐨𝐦 𝐄𝐦𝐛𝐫𝐲𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬 𝐭𝐨 𝐂𝐚𝐧𝐜𝐞𝐫 The authors unravel the pathway’s complex mechanisms, explaining how its dysregulation is linked to a spectrum of diseases, including various cancers. They emphasize the pathway's versatility, illustrating how the same signaling cascade is repurposed across different contexts to perform vital roles in both normal development and disease progression. 𝐂𝐡𝐚𝐫𝐭𝐢𝐧𝐠 𝐍𝐞𝐰 𝐓𝐞𝐫𝐫𝐢𝐭𝐨𝐫𝐲: 𝐓𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐍𝐨𝐭𝐜𝐡 𝐒𝐢𝐠𝐧𝐚𝐥𝐢𝐧𝐠 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 The review doesn’t just look back at what has been established but also charts new territory for future research. The authors call for deeper exploration into the pathway’s regulatory mechanisms, urging scientists to address the many unanswered questions surrounding Notch signaling's role in development and disease. This insightful review is a must-read for anyone involved in developmental biology, oncology, and cell signaling research. #DevelopmentalBiology #CellSignaling #CancerResearch #NotchSignaling #BiomedicalScience #MolecularGenetics #ResearchInnovation #FEBSJournal #ScientificReview
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