Arc Institute’s Post

Come learn about the PhenoCycler-Fusion and PhenoImager HT and how our local academic and biotech scientists are using them to accelerate their spatial biology research! All are welcome to join for some or all of the talks. Check out the agenda!

Have you ever thought that your science could make an impact on your community? Don't know where to start translating your idea to be available to the public? Learn some of the first steps to understanding the commercialization process.

We are investing $13M toward a new research collaboration with scientists from Duke University School of Medicine, Columbia University Irving Medical Center and Stanford University to expand the collective understanding of G protein-coupled receptors (GPCR), which are vital proteins that impact human health and disease and have been linked to or implicated in more than 100 human diseases and disorders. They will use advanced methodologies like cryo-electron microscopy and data science to pursue new strategies to treat a number of diseases, including pediatric cancers. The Research Collaboratives Program is part of an overall effort by St. Jude to fund collaborative research to speed up discoveries that could address complex scientific questions with transformative potential. Since 2017, we have funded $80M for six different Research Collaborative projects. By 2027, we will support more Research Collaboratives for a total $160 million investment. https://bit.ly/3SnluYV

📣 New Paper Alert! 📣 Many great thinkers highlighted the importance of debate in Science. Popper, Kuhn, Feyerabend, just to name some of the giants on whose shoulders we stand. 🤔 Debate can push us out of our comfort zone and be emotionally threatening, but engaging with the process can often lead to both collective and personal progress. From a collective point of view, the importance of constructive scientific debate lies in its functional role. It advances scientific knowledge, promote transparency and plurality, fosters innovation, and engages the public in scientific discourse. 👨🔬 I am therefore honoured to have the opportunity to participate in a critical discussion about the role of slow alpha brain frequency as a biomarker of pain. Our contribution in a nutshell: 🔬 We re-analysed our previous data obtained in healthy individuals exposed to different prolonged sensory conditions, including hand immersion in painful hot water. 💡 Our re-analysis partly supported the idea that the slow alpha oscillations recorded during resting state may be independent from the slowing that these oscillations manifest during the experience of pain. 💡 We found weak support to the idea that the slow alpha oscillations recorded during resting state can be predictive of pain perception. 🤷♂️ Our new results are consistent with our previous conclusions. Methodological differences between studies may explain the lack of replication. 👫 Other groups also shows mixed results, indicating a need for diverse methodologies and collaborative multi-lab projects to advance the field. For those interested in reading more about it, here you find the open access link: https://lnkd.in/ejNC6fwz Special thanks to my co-authors Sebastian Halder and Vincenzo Romei who bore with me in this long (and eventful...) journey. #Research #Pain #Science #Neuroscience #AlphaOscillations University of Essex

"My research focuses on innate immunity and cell death, with specific emphasis on inflammasome and cGAS-STING, as well as novel programmed cell death." Learn more about this month's Postdoc Spotlight, featuring Ze Zhang, PhD, a student in the lab of Dr. Kate Fitzgerald in the Division of Innate Immunity. https://lnkd.in/eB7kkGkz

𝐍𝐞𝐰 𝐛𝐞𝐠𝐢𝐧𝐧𝐢𝐧𝐠, 𝐒𝐚𝐦𝐞 𝐠𝐫𝐞𝐚𝐭 𝐭𝐫𝐚𝐝𝐢𝐭𝐢𝐨𝐧 📢 💼🔬🧬 Science remains the tradition that drives innovation, be it in Academia, Industry or in Government. It's a brand new beginning for me at the National Center for Advancing Translational Sciences (NCATS), NIH! Happy to share that I’ve started as a Postdoctoral Research Fellow and grateful to join Dr. Xia Menghang in the Tox21 Program at the Division of Preclinical Investigation. This transition is exciting as I will be engaging in translational work, advancing from my previous doctoral work in academia. NIH... Turning Discovery into Health

The United States Department of Defense has awarded a $308,000 grant to the University of Tennessee-Health Science Center College of Medicine's Mohammad Moshahid Khan, PhD, and Jianfeng Xiao, MD, PhD, to investigate the role of the gut microbiome in dystonia with the hope of improving neurobehavioral outcomes. Although dystonia has no cure, the research team hopes to discover new therapies with fewer significant side effects. “The study opens up an entirely new direction on dystonia research and will provide a significant positive impact by defining the role of gut microbiome in the dystonia pathobiology and testing the impact of the microbiome approach in mitigating the neurobehavioral function in the dystonia," said Dr. Khan. Learn more about the study by reading our full coverage: https://lnkd.in/eXpUe56A

Thinking about it...everyone working in science should think about oxygen. Not only the ones interested in HIF signaling, no! Wrong oxygen levels in experimentation does affect your results! If you now think 'why? how?' - join HypoxEU community to learn more! If you work in plant biology, marine biology, materials sciences, radiation biology, environmental biology, immunology, cancer, regenerative medicine, genetics, cardiology, developmental biology, reproductive sciences,  microbiology, paracitology, endocrinology, ophthalmology, virology, aging, wound  healing, diabetes, cell signaling, crop sciences, high altitude medicine....just to mention a few... you need to use NOT AMBIENT but PHYSIOLOGICAL oxygen levels when doing the experiments. To join the community, go to www.hypoxeu.com. For next oxygen biology symposium, HypoxEU Live in Dresden is open for registration! Register by the end of Feb through www.hypoxeu.com! #oxygen #hypoxia #physioxia

In case you missed it, yesterday we had an incredible event Pat MacDonald, PhD, & Jess Ewald, PhD, University of Alberta & Broad Institute discussed HumanIslets.com: A new open resource for the islet community. 📺 Watch the full recording now: https://lnkd.in/gzyY3Y4g #TheSugarScience #DiabetesResearch #HumanIsletResearch #IsletBiology #HumanIslets #DataScience #betacell #islettransplant #insulinsecretion #neuroendocrine #transplantation #pvalue #omics #isletvariation #phenotyping #donor #metadata #linearmodels #limmaRpackage #statisticalanalysis #glucose #leucine #palmitate #mitochondrialfunction #electrophysiology #diabetesdiagnosis

𝗛𝗼𝘄 𝘁𝗵𝗲 𝗣𝗼𝗿𝘁-𝗮-𝗣𝗮𝘁𝗰𝗵 𝗶𝘀 𝗿𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗶𝗻𝗴 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝗰𝗿𝗼𝘀𝘀 𝘁𝗵𝗲 𝗴𝗹𝗼𝗯𝗲 🌎 The Port-a-Patch is a miniaturized patch clamp system that allows users to quickly and easily obtain high-quality data, regardless of their level of experience. It is an ideal tool for learning and teaching the fundamentals of patch clamp, as well as for conducting advanced research in various fields. The 𝗣𝗼𝗿𝘁-𝗮-𝗣𝗮𝘁𝗰𝗵 has been a pioneer in the field for two decades, offering a small and compact device with sophisticated technology. It can produce 𝗵𝗶𝗴𝗵-𝗾𝘂𝗮𝗹𝗶𝘁𝘆 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝗺𝗲𝗻𝘁𝘀 with giga-seals and high success rates in all recording configurations. In this playlist, you will learn how four scientists from different disciplines are using the Port-a-Patch to advance their research: 🔵 Christine Beeton (Baylor College of Medicine, USA): Assessing the efficacy of a bacteria-based drug delivery system for autoimmune diseases 🔵 Samuel Fountain (University of East Anglia, UK): Exploring the function and pharmacology of P2X receptors, which are involved in pain, inflammation, and neurodegeneration 🔵 Marcus Schewe (Kiel University, DE) : Unraveling the molecular basis of TREK K2P channel gating, which regulates neuronal excitability, mood, and pain 🔵 Elizabeth Kim (Weill Cornell Medicine, USA): Uncovering a small molecule binding site for modulation of HCN1 channels, which are important for learning and memory After 20 years on the market, the Port-a-Patch is still the preferred choice of scientists worldwide to perform electrophysiology experiments easily and efficiently. Watch the playlist and discover how the Port-a-Patch can help you achieve your research goals: https://ow.ly/h5nO50Qt4Qs #IonChannels #Electrophysiology #PatchClamp #VoltageClamp