Conigen Bioscience, Inc.

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Nature is a master architect, quietly designing complex molecular structures that support life. At Conigen, we bring these hidden designs to light, harnessing them to cis-dimer proteins that power cancer therapies.   Explore how we’ve unlocked nature’s silent architecture, swipe through to see how we connect nature’s wisdom with the future of science. #DimerProtein #CancerResearch #ProteinsInTherapy #ConigenInnovation   Experience nature’s designs in your lab: https://lnkd.in/eNEyd9Fh

Bioactive Nectin-4 Homodimer as Immunogen & Antigen – Custom Bioengineering Capabilities   Nectin-4, a homodimer, is overexpressed on various types of tumor cells including pancreatic cancers. It has been recently identified as a novel ligand of TIGIT and interaction between Nectin-4 and TIGIT inhibits NK cell cytotoxicity thus suppressing immune responses, allowing cancer cells to evade immune surveillance. Studying recombinant Nectin-4 dimer binding potency to its receptor vs the monomer form, demonstrates how the dimer can be used as an immunogen and an antigen to increase the potential of antibody discovery when targeting quaternary structural epitopes.   The challenge is engineering conformationally stable bioactive cis-dimer proteins to be able to perform in vitro analyses and animal immunization.   Conigen Experts are dedicated to engineering and delivering bioactive conformational cis-dimer proteins to advance discovery of the next generation therapeutics. These are functional, pure and stable extracellular domain novel proteins that can be used as immunogens or antigens. Whether you’re in translational research, discovering new therapeutics or developing antibodies, our custom bioactive protein production capabilities are engineered to meet your high standards. Request the poster here: https://lnkd.in/eYKTJb88   #ProteinEngineering #ConformationalDimerProteins #BioactiveProteins #AACR2024 Learn more: https://lnkd.in/eaW7BsHe              

Nature is a master architect, quietly designing complex molecular structures that support life. At Conigen, we bring these hidden designs to light, harnessing them to create membrane proteins that power cancer therapies. Explore how we’ve unlocked nature’s silent architecture, swipe through to see how we connect nature’s wisdom with the future of science. #MembraneProtein #CancerResearch #ProteinsInTherapy #ConigenInnovation Experience nature’s designs in your lab: https://lnkd.in/eZ2CXKZD

Shixia Wang, PhD, Chief Scientific Officer and Co-Founder of Conigen Bioscience, Inc., recently presented the poster "Engineered novel bioactive Nectin-4 Cis-homodimer protein significantly enhances the binding of TIGIT" at the American Association for Cancer Research Special Conference: Advances in Pancreatic Cancer Research in Boston. Congratulations to the Conigen team for this remarkable contribution to advancing cancer research! Request a copy of the poster here: https://lnkd.in/eYKTJb88 #CancerResearch #PancreaticCancer #ProteinEngineering #ConformationalDimerProteins #BioactiveProteins #AACR2024

Bioactive Nectin-4 Homodimer vs Monomer – Custom Bioengineering Capabilities   Nectin-4, a homodimer, is overexpressed on various types of tumor cells including pancreatic cancers. It has been recently identified as a novel ligand of TIGIT and interaction between Nectin-4 and TIGIT inhibits NK cell cytotoxicity thus suppressing immune responses, allowing cancer cells to evade immune surveillance.    The challenge is engineering conformationally stable bioactive cis-dimer proteins to be able to perform in vitro analyses and animal immunization.   Conigen Experts are dedicated to engineering and delivering bioactive conformational cis-dimer proteins to advance discovery of the next generation therapeutics. These are functional, pure and stable extracellular domain novel proteins that can be used as immunogens or antigens. Whether you’re in translational research, discovering new therapeutics or developing antibodies, our custom bioactive protein production capabilities are engineered to meet your high standards.   #ProteinEngineering #ConformationalDimerProteins #BioactiveProteins #AACR2024 Learn more: https://lnkd.in/eNEyd9Fh 

Bioactive Nectin-4 Homodimer, Immuno-oncology Target – Custom Bioengineering Capabilities   Nectin-4, a homodimer, is a cell adhesion molecule involved in cell-cell junctions and plays a role in cancer progression by influencing cell adhesion, migration, and proliferation.    The challenge is engineering conformationally stable bioactive cis-dimer proteins to be able to perform in vitro analyses and animal immunization.   Conigen Experts are dedicated to engineering and delivering bioactive conformational cis-dimer proteins to advance discovery of the next generation therapeutics. These are functional, pure and stable extracellular domain novel proteins that can be used as immunogens or antigens. Whether you’re in translational research, discovering new therapeutics or developing antibodies, our custom bioactive protein production capabilities are engineered to meet your high standards.   #ProteinEngineering #ConformationalDimerProteins #BioactiveProteins #AACR2024 #ImmunoncologyTarget Learn more: https://lnkd.in/eaW7BsHe

Custom Conformational Bioactive Soluble Cis-Dimer Proteins –   Fast-track your Drug Discovery Program!   Proteins form homo-, hetero-, or oligomerization in the cellular environment to regulate a range of cellular processes. An estimate of 30-50% of proteins is oligomeric and over 50% of those are dimeric proteins. Receptor dimerization is a common mechanism for receptor-target interaction and catalytic activity. Dimeric proteins possess a quaternary structure, the highest protein structural order. Targeting quaternary conformational epitopes of the dimeric interface is critical for therapeutic antibodies with better specificity and potency.   The challenge is engineering conformationally stable bioactive cis-dimeric proteins.   Conigen Experts are dedicated to engineering bioactive conformational dimer proteins to advance discovery of next generation therapeutics. #ProteinEngineering #ConformationalDimerProteins #BioactiveProteins   Learn more: https://lnkd.in/eaW7BsHe

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