Our CEO Michelle Werner will be speaking twice at RNA Leaders, taking place this week in #SanDiego. Thursday, September 5th 1:55 pm to 2:20 pm PT Talk – Leveraging Machine Learning to Design tRNA Medicines to Treat Stop Codon Disease 3:30 pm to 4:15 pm PT Closing Keynote Plenary Panel – RNA Revolution: Deciphering the Investment Landscape - Modality, Technology or Indication? See more info here: https://lnkd.in/g93QgSzv #RNA #tRNAmedicines #tRNAbiology #rarediseases #geneticmedicines #programmablemedicines #AI #machinelearning #StopCodonDisease
Alltrna
Biotechnology Research
Cambridge, Massachusetts 6,771 followers
The world’s first transfer RNA (tRNA) platform company. We are unlocking the vast therapeutic potential within #tRNA.
About us
Alltrna is the first transfer RNA (tRNA) platform company, and our mission is to unlock tRNA biology and pioneer tRNA therapeutics to regulate the protein universe and resolve disease. Founded at Flagship Labs in 2018, Alltrna has mapped tRNA biology to systematically design tRNA medicines and encode a completely new, unifying approach to treating both rare and common human diseases driven by shared genetic mutations. Alltrna’s platform combines internal expertise and proprietary machine learning tools to unlock the entire tRNA biology space. We have an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
- Website
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http://www.alltrna.com
External link for Alltrna
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- Cambridge, Massachusetts
- Type
- Privately Held
- Founded
- 2018
Locations
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Primary
Cambridge, Massachusetts, US
Employees at Alltrna
Updates
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🤔 Why should you get genetic testing if you already have a diagnosis? New animated videos from the National Organization for Rare Disorders outline many of the reasons, such as determining the best treatment, expanding clinical trial options, and providing additional support. We are proud to have provided funding to support the educational videos, which were created in English and Spanish in partnership with the National PKU Alliance and Osmosis.org from Elsevier. Watch the video here: https://lnkd.in/gdTF9KRQ #NORD #rarediseases #genetictesting #geneticcounseling #clinicalresearch #patientpower
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What a great way to help nourish our community! A team of Alltrna volunteers helped out two fantastic local charities, Cradles to Crayons and Community Servings during our Day of Service. We're proud to support their missions to end clothing insecurity and to provide medically tailored meals to chronically and critically ill individuals. 📸 Check out these snapshots from the day. Learn more about the charities: 🖍️ Cradles to Crayons: https://lnkd.in/eBYT4Hn 🍲 Community Servings: https://www.servings.org #FoodAsMedicine #EndClothingInsecurity #CommunityService #DayofService #WeAreAlltrna #GivingBack
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Alltrna’s CEO Michelle Werner discusses with Larry Luxner of Rare Disease Advisor her personal and professional mission to accelerate #raredisease #drugdevelopment and how new tRNA genetic medicines could do this: by treating many diseases at once. 🎧 Listen to the interview: https://lnkd.in/gStF48fc #tRNA #RNA #tRNAmedicines #tRNAbiology #rarediseases #StopCodonDisease #geneticmedicines #programmablemedicines
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We are excited to share that Alltrna has been selected as a finalist for the Biotech Innovation award at the upcoming Biotech Week Boston Awards! The Biotech Innovation award recognizes a company that has conceived a new or advancing biopharmaceutical product, manufacturing process, or ground-breaking technology that yielded significant results. Being named a finalist recognizes the significant advancements Alltrna is making to turn tRNA’s unique biology into transformative genetic medicines. For more info, visit: https://lnkd.in/e-sU54RS #BiotechWeekBoston #BWBAwards #InnovationInBiotech #tRNA #tRNAmedicines #rarediseases #raredisease #StopCodonDisease #geneticmedicines #programmablemedicines
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Of the ~300 million people around the world with a genetic disease, an estimated 10% have a nonsense mutation that causes a premature stop codon. Our CEO Michelle Werner shares with Daniel Levine how Alltrna is developing tRNA therapeutics as universal medicines for these diseases and why a single medicine has the potential to work across nonsense mutations regardless of the gene in which they occur. In this #podcast episode of #RARECast from #GlobalGenes, hear more about how Alltrna designs their tRNA medicines and why this therapeutic approach has the potential to address so many diseases at once. Listen here or read the interview transcript: https://lnkd.in/gV-CQJYk #RNA #tRNA #tRNAbiology #rarediseases #geneticmedicines #StopCodonDisease #tRNAmedicines #machinelearning #AI
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Why does Alltrna need #machinelearning to unlock #tRNA biology? tRNAs are programmable molecules with a diverse biology of sequences and modifications that are key to their structure, function, and stability. There’s the potential for approximately 10^34 tRNA sequences and more than 120 natural and synthetic modifications for each nucleotide – yielding the opportunity to generate more engineered tRNA oligonucleotides than atoms in the universe What this diversity means is that there is a huge amount of flexibility in tRNA sequences without perturbing their function. Our ML-enabled platform empowers Alltrna to explore the possible sequence space to design therapeutic molecules optimized not only for biological activity, but also for tolerability, stability, manufacturability, and a host of other characteristics required in drug design. Our CEO Michelle Werner will explore this topic and more at the #RNALeaders conference in #SanDiego next month. Hear a preview of the talk here: https://lnkd.in/gPqgNu3R See the RNA Leaders conference agenda here – note new day/time for the talk: https://lnkd.in/g93QgSzv #RNA #tRNAmedicines #tRNAbiology #rarediseases #geneticmedicines #programmablemedicines #AI #machinelearning #StopCodonDisease
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🏖️ Relaxed, rejuvenated, and returning with a renewed focus on our mission. The Alltrna team enjoyed a synchronous #summerbreak at the beginning of July. It was a wonderful opportunity to reconnect with family, friends, and the world around us. Here's a peek at what we got up to. #EmployeeWellness #WorkLifeBalance #Innovation #WeAreAlltrna
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Our CEO Michelle Werner chats with Tides Global about her journey leading up to being CEO at Alltrna and how her personal experiences influenced her career to advance novel therapeutics. Read more at @Informa: https://lnkd.in/g-2cBwry #rarediseases #geneticmedicines #tRNA
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Alltrna reposted this
Had a great discussion today with Congressional leaders and Paul Melmeyer of the Muscular Dystrophy Association and Maynard Friesz of Cure SMA about the importance of the rare pediatric disease priority review voucher (PRV) program. Thank you to National Organization for Rare Disorders for organizing the Senate briefing and to Karin Hoelzer for moderating. #PRV #rarediseases #raredisease #drugdevelopment #innovation #patientsdeservebetter