This production started filming in Chicago in January 2020 and (according to a September 2021 Steve Greene article in IndieWire) was about one-fifth completed before having to shut down in March 2020 because of the COVID-19 pandemic. Filming resumed in February 2021 in Canada, and wrapped that July. So this series about life before, during, and after a catastrophic worldwide pandemic was filmed before and during (and aired during) a catastrophic worldwide pandemic.
The novel takes place in Toronto, but the show takes place in Chicago. Although much of it was filmed in the Greater Toronto Area.
Both Mackenzie Davis and Caitlin FitzGerald play characters who are actors in Station Eleven. The two previously starred together in the movie "Always Shine" where both played characters who were actors.