#=GF ID   DUF3804
#=GF AC   PF12707.13
#=GF DE   Protein of unknown function (DUF3804)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   jcsg_3hzp
#=GF GA   22.50 22.50;
#=GF TC   22.70 22.80;
#=GF NC   22.30 21.80;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0051
#=GF DR   INTERPRO; IPR024525;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is approximately 130 residues.  Dali search
#=GF CC   indicates this protein carries a NTF2-fold with a hydrophobic
#=GF CC   cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0. 
#=GF CC   In this hydrophobic cavity, Arg 118 provides the H-bonding force
#=GF CC   to hold a PEG molecule from crystallisation. The interface
#=GF CC   interaction suggests that the biomolecule of Swiss:Q46KI2 is a
#=GF CC   dimer. Two members of the family are annotated as putative EF-Tu
#=GF CC   domain 2 but there is no match to this family so this is likely
#=GF CC   to be a false assignment. There are two highly conserved
#=GF CC   tryptophan residues towards the C-terminal end of the family.
#=GF SQ   14
#=GS A3PEN9_PROM0/2-72        AC A3PEN9.1
#=GS F0Y588_AURAN/1-120       AC F0Y588.1
#=GS A0A8J2SEK0_9STRA/68-194  AC A0A8J2SEK0.1
#=GS Q46KI2_PROMT/2-129       AC Q46KI2.1
#=GS Q46KI2_PROMT/2-129       DR PDB; 3HZP A; 2-128;
#=GS R1EHD2_EMIHU/1-95        AC R1EHD2.1
#=GS K8F230_9CHLO/3-127       AC K8F230.1
#=GS Q46H33_PROMT/23-149      AC Q46H33.1
#=GS Q46KN8_PROMT/1-47        AC Q46KN8.1
#=GS A9BC66_PROM4/14-140      AC A9BC66.1
#=GS A0A1Y1IDG9_KLENI/76-189  AC A0A1Y1IDG9.1
#=GS A7MDJ2_PROMT/1-30        AC A7MDJ2.1
#=GS V4XX68_9PROT/5-131       AC V4XX68.1
#=GS K0RBM3_THAOC/91-205      AC K0RBM3.1
#=GS C1FHB7_MICCC/1-82        AC C1FHB7.1
A3PEN9_PROM0/2-72                   .......................slli---------------QKKMA..SFFVDNATPDFLFIRPSGNP.IDAKGFEKMITC.-DIVQEKAEIT..KIHRF..EF.L.NENIVMCIFTLG------------.--.----.--.--.-.---------------.-------.....
F0Y588_AURAN/1-120                  ........................maa----ELETMISEFCSI-KMG..DWIAGNTTDDFQFVRPTGNP.IDKIGFPAMM-T.GDVVVQAGELK..KIHKL..E-.V.SGDMAFACLTQYGKFTYKGTPNED.IC.VMTL.IF.KK.V.DGAWKLAWAQRSSGR.-------kpd..
A0A8J2SEK0_9STRA/68-194             ..........................a-DEQELKGMIKSMAE-DKTG..EWIAANCLPDALFIRPSGNP.FKAAEFVTFFG-.GDVEITEKALL..KIQKL..D-.V.GADMAYATASESAKFTYKGTPNDD.PSfTVST.VW.KK.V.GGAWKLAHGHRSTATgNDMSSWD.....
Q46KI2_PROMT/2-129                  ...........................SSKEEILSILEAFASTERMG..SFFLDNATADFLFIRPSGNP.LDAKGFENMWSS.GDLVLESAEIT..KVHKF..EL.L.GSNAAICVFTLGSKFTYKGTQNDD.LP.TVTS.IF.KK.I.DEKWKVAWMQRSSGQ.SDMTLWN.....
#=GR Q46KI2_PROMT/2-129       SS    ...........................-HHHHHHHHHHHHSSTTTTT..THHHHHB-TT--EE-TTS-E.E-HHHHHHHHTS.SSEEEEEEEEE..EEEEE..EE.S.SSSEEEEEEEEEEEEEETTEEEEE.B-.EEEE.EE.EE.E.TTEEEEEEEEE--SB.--GGG-X.....
R1EHD2_EMIHU/1-95                   .........................ad--------------------..--------DDVQMIRPSGNP.LSKAEWATMFAS.EDVVIESDELV..SIDSV..RIfA.GGNAAVATYSKHSKFIYKGDENDD.YA.VFSA.TL.EK.K.GGDWKVVFVMRATG-.-------.....
K8F230_9CHLO/3-127                  .......................teet----QLRELIKDQLTTA-NK..EEFLAKMPQNAWFIRPSGNP.ASKEIMVEMMSS.GDITEAKTELV..EIKHV..E-.V.MQDCAYAVLIAKSSFDYKQTKNED.VY.TQSC.FF.KK.TsDGKFELAWGHRSTGR.-------gfeed
Q46H33_PROMT/23-149                 ...........................SDSQQLEALIQSFADRSQNK..TFLLANTTNDFLAIRPSCNP.IIAKGLAGMYDS.DDLVIELSELV..KIHRL..E-.A.DSDWGFTAFTLKEVFSYKGDLNND.LS.IYSL.IF.KK.I.DGIWKIVWMQRSQGT.TDISTWD.....
Q46KN8_PROMT/1-47                   ...........................--------------------..--------------------.------------.-----------..-----..--.-.----------MKEEFNYKGERNND.LS.SYSL.IF.KK.I.DGTWKISWMQRSQGT.TDLSTW-s....
A9BC66_PROM4/14-140                 ...........................SDSQSIEALIKGFANRSENK..SFLISNVTENFLAIRPSGNP.ITAEDLVGMYNN.ADLVVEVSELV..KIHRL..E-.A.NADWGFAAFTLKEQFSYKGENNND.LS.SYSM.IF.QK.R.DGAWKISWMQRSSGT.TDLSTWN.....
A0A1Y1IDG9_KLENI/76-189             ....ayiqngisnvwytssedaiipgg--------------------..-----------MFIRASGNP.LKMEGLAAFVEE.NDELFEE-KVL..DIEKL..E-.I.RGDVAWTVLKMYQDFSYRGTRHKD.TF.RYTV.ILeRK.P.LERWRVAHMHRSS--.-------plke.
A7MDJ2_PROMT/1-30                   ...........................--------------------..-----------MAIRPSGNP.ITAEGLAGMYDS.ADLVIELSE--..-----..--.-.------------------------.--.----.--.--.-.---------------.-------.....
V4XX68_9PROT/5-131                  .........................in--EDDIQALIKNFSSVGKNV..DVVKTRTTPDFRFIRPSGNP.LDAAGFAHMFAS.GELVMQSIGLS..KVHRL..D-.V.YGERAFAAFTQVATFTYKGEPNDD.VF.TVTA.LF.EK.I.DGLWYFSWMQRSSGQ.ADSAAW-f....
K0RBM3_THAOC/91-205                 ......gyrhtslrclyalnckqlslg--------------------..------------RIRPSGNP.ITPQGMAAMFDS.GDVEPGLSELI..GVDSI..RLlA.GGAAAVATYTHHSTFKYKGIPNDD.IA.KFTV.VL.EK.T.PEGWKMVHGHRSTGQ.Q------pek..
C1FHB7_MICCC/1-82                   .........................mm--------------------..--------------------.------KAMMDS.KDVTGVSGDLI..DIKML..DF.SeDRTMAYSAVVASATFSYKGTPNDD.VY.VFTN.VF.KK.V.DGVWETVWGHRSTGR.S------pde..
#=GC SS_cons                        ...........................-HHHHHHHHHHHHSSTTTTT..THHHHHB-TT--EE-TTS-E.E-HHHHHHHHTS.SSEEEEEEEEE..EEEEE..EE.S.SSSEEEEEEEEEEEEEETTEEEEE.B-.EEEE.EE.EE.E.TTEEEEEEEEE--SB.--GGG-X.....
#=GC seq_cons                       ..........................................................shhhIRPSGNP.lsttshssMhso.sDllhptsELh..cIc+l..-..s.sushAhsshohttpFsYKGp.NcD.l..shoh.la.cK.h.sGtW+lsahpRSoGp.............
//