skip to main content
10.1145/3014812.3014871acmotherconferencesArticle/Chapter ViewAbstractPublication Pagesaus-cswConference Proceedingsconference-collections
research-article

Understanding chronic disease comorbidities from baseline networks: knowledge discovery utilising administrative healthcare data

Published: 31 January 2017 Publication History

Abstract

Hospitals routinely collect admitted patients' data for administrative purposes and for reporting to the government and health insurers. These heterogeneous and mostly untapped data contain rich semantic information about patients' health conditions in the form of standard disease codes. These traces of clinical information can be aggregated over patients to understand how their health progresses over time. When applied on particular chronic disease patients, this approach can potentially help in understanding chronic disease comorbidities as well as in the knowledge discovery on how the chronic disease progresses over time. In this paper, we propose a network-based approach to extract semantic information from hospital administrative data in order to develop a representation of chronic disease progression specifically - type 2 diabetes. We then propose measures for attribution adjustment that ranks the more prevalent comorbidities in chronic patients higher, compared to the non-chronic ones. We also have applied the framework on the administrative data of 2,760 sampled patients to understand how diabetes progresses over time through different comorbidities. This understanding can be effectively converted to actionable intelligence that can be useful in the formulation of better health policy and resource management.

References

[1]
World Health Organization, 2012. Preventing chronic diseases: a vital investment. Geneva: WHO, 2005.
[2]
Ward, B., Schiller, J., and Goodman, R., 2014. Multiple chronic conditions among US adults: a 2012 update. Prev. Chronic Dis. 11.
[3]
Australian Institute of Health and Welfare (AIHW), 2014. Australia's Health 2014.
[4]
Kopelman, P.G., 2000. Obesity as a medical problem. Nature 404, 6778, 635--643.
[5]
Rathmann, W., Haastert, B., Icks, A.a., Löwel, H., Meisinger, C., Holle, R., and Giani, G., 2003. High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 46, 2, 182--189.
[6]
Gregg, E.W., Cadwell, B.L., Cheng, Y.J., Cowie, C.C., Williams, D.E., Geiss, L., Engelgau, M.M., and Vinicor, F., 2004. Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the US. Diabetes Care 27, 12, 2806--2812.
[7]
Taubert, G., Winkelmann, B.R., Schleiffer, T., März, W., Winkler, R., Gök, R., Klein, B., Schneider, S., and Boehm, B.O., 2003. Prevalence, predictors, and consequences of unrecognized diabetes mellitus in 3266 patients scheduled for coronary angiography. Am. Heart J. 145, 2, 285--291.
[8]
MacKenzie, E.J., Morris Jr, J.A., and Eeelstein, S.L., 1989. Effect of pre-existing disease on length of hospital stay in trauma patients. Journal of Trauma and Acute Care Surgery 29, 6, 757--765.
[9]
Umpierrez, G.E., Isaacs, S.D., Bazargan, N., You, X., Thaler, L.M., and Kitabchi, A.E., 2002. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. The Journal of Clinical Endocrinology & Metabolism 87, 3, 978--982.
[10]
Lauruschkat, A.H., Arnrich, B., Albert, A.A., Walter, J.A., Amann, B., Rosendahl, U.P., Alexander, T., and Ennker, J., 2005. Prevalence and risks of undiagnosed diabetes mellitus in patients undergoing coronary artery bypass grafting. Circulation 112, 16, 2397--2402.
[11]
Tenenbaum, A., Motro, M., Fisman, E.Z., Boyko, V., Mandelzweig, L., Reicher-Reiss, H., Graff, E., Brunner, D., and Behar, S., 2000. Clinical impact of borderline and undiagnosed diabetes mellitus in patients with coronary artery disease. The American journal of cardiology 86, 12, 1363--1366.
[12]
Kapur, V., Sandblom, R.E., Hert, R., James, B., and Sean, D., 1999. The medical cost of undiagnosed sleep apnea. Sleep 22, 6, 749.
[13]
Harris, M.I., 1993. Undiagnosed NIDDM: clinical and public health issues. Diabetes Care 16, 4, 642--652.
[14]
Khan, A., Uddin, S., and Srinivasan, U., 2016. Adapting graph theory and social network measures on healthcare data: a new framework to understand chronic disease progression. In Proceedings of the Australasian Computer Science Week Multiconference ACM, 66.
[15]
Charlson, M.E., Pompei, P., Ales, K.L., and MacKenzie, C.R., 1987. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 40, 5, 373--383.
[16]
Elixhauser, A., Steiner, C., Harris, D.R., and Coffey, R.M., 1998. Comorbidity measures for use with administrative data. Med. Care 36, 1, 8--27.
[17]
Sharabiani, M.T., Aylin, P., and Bottle, A., 2012. Systematic review of comorbidity indices for administrative data. Med. Care 50, 12, 1109--1118.
[18]
Wong, D.T. and Knaus, W.A., 1991. Predicting outcome in critical care: the current status of the APACHE prognostic scoring system. Can. J. Anaesth. 38, 3, 374--383.
[19]
Breslow, M.J. and Badawi, O., 2012. Severity scoring in the critically ill: part 1---interpretation and accuracy of outcome prediction scoring systems. CHEST Journal 141, 1, 245--252.
[20]
Barabási, A.-L., 2007. Network medicine---from obesity to the "diseasome". N. Engl. J. Med. 357, 4, 404--407.
[21]
Loscalzo, J., Kohane, I., and Barabasi, A.L., 2007. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol. Syst. Biol. 3, 1.
[22]
Burton, P.R., Clayton, D.G., Cardon, L.R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D.P., McCarthy, M.I., Ouwehand, W.H., and Samani, N.J., 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 7145, 661--678.
[23]
Hidalgo, C.A., Blumm, N., Barabási, A.-L., and Christakis, N.A., 2009. A dynamic network approach for the study of human phenotypes. PLoS Comput. Biol. 5, 4, e1000353.
[24]
Ideker, T. and Sharan, R., 2008. Protein networks in disease. Genome Res. 18, 4, 644--652.
[25]
Davis, D.A., Chawla, N.V., Christakis, N.A., and Barabási, A.-L., 2010. Time to CARE: a collaborative engine for practical disease prediction. Data Mining and Knowledge Discovery 20, 3, 388--415.
[26]
Davis, D.A., Chawla, N.V., Blumm, N., Christakis, N., and Barabási, A.-L., 2008. Predicting individual disease risk based on medical history. In Proceedings of the 17th ACM conference on Information and knowledge management ACM, 769--778.
[27]
Breault, J.L., Goodall, C.R., and Fos, P.J., 2002. Data mining a diabetic data warehouse. Artif. Intell. Med. 26, 1, 37--54.
[28]
Baglioni, M., Pieroni, S., Geraci, F., Mariani, F., Molinaro, S., Pellegrini, M., and Lastres, E., 2013. A New Framework for Distilling Higher Quality Information from Health Data via Social Network Analysis. In Data Mining Workshops (ICDMW), 2013 IEEE 13th International Conference on IEEE, 48--55.
[29]
Anderson, J.G., 2002. Evaluation in health informatics: social network analysis. Comput. Biol. Med. 32, 3, 179--193.
[30]
World health Organization, 2014. WHO | International Classification of Diseases (ICD).
[31]
Luijks, H., Schermer, T., Bor, H., van Weel, C., Lagro-Janssen, T., Biermans, M., and de Grauw, W., 2012. Prevalence and incidence density rates of chronic comorbidity in type 2 diabetes patients: an exploratory cohort study. BMC Med. 10, 1, 128.
[32]
Folino, F., Pizzuti, C., and Ventura, M., 2010. A comorbidity network approach to predict disease risk. In Information Technology in Bio-and Medical Informatics, ITBAM 2010 Springer, 102--109.
[33]
Fetter, R.B., Shin, Y., Freeman, J.L., Averill, R.F., and Thompson, J.D., 1980. Case mix definition by diagnosis-related groups. Med. Care, i--53.
[34]
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L.D., Beck, C.A., Feasby, T.E., and Ghali, W.A., 2005. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med. Care, 1130--1139.
[35]
Garland, A., Fransoo, R., Olafson, K., Ramsey, C., Yogendren, M., Chateau, D., and McGowan, K., 2012. The epidemiology and outcomes of critical illness in Manitoba. University of Manitoba, Faculty of Medicine, Department of Community Health Sciences.
[36]
American Diabetes Association, 2013. Kidney Disease (Nephropathy). In Living With Diabetes.
[37]
National Heart, L., and Blood Institute, 2015. Who Is at Risk for Heart Valve Disease? In Heart Valve Diseases.
[38]
Benjamin, E.J., Levy, D., Vaziri, S.M., D'Agostino, R.B., Belanger, A.J., and Wolf, P.A., 1994. Independent risk factors for atrial fibrillation in a population-based cohort: the Framingham Heart Study. JAMA 271, 11, 840--844.

Cited By

View all
  • (2022)Predictive Modelling of Diseases Based on a Network and Machine Learning ApproachRecent Challenges in Intelligent Information and Database Systems10.1007/978-981-19-8234-7_50(641-654)Online publication date: 24-Nov-2022
  • (2019)Development and exploration of polymedication network from Pharmaceutical and Medicare Benefits Scheme dataProceedings of the Australasian Computer Science Week Multiconference10.1145/3290688.3290738(1-6)Online publication date: 29-Jan-2019
  • (2018)Methodology for the Design of a Student Pattern Recognition Tool to Facilitate the Teaching - Learning Process Through Knowledge Data Discovery (Big Data)Data Mining and Big Data10.1007/978-3-319-93803-5_63(670-679)Online publication date: 10-Jun-2018

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Other conferences
ACSW '17: Proceedings of the Australasian Computer Science Week Multiconference
January 2017
615 pages
ISBN:9781450347686
DOI:10.1145/3014812
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

Publisher

Association for Computing Machinery

New York, NY, United States

Publication History

Published: 31 January 2017

Permissions

Request permissions for this article.

Check for updates

Author Tags

  1. attribution
  2. chronic disease
  3. data mining
  4. diabetes
  5. health informatics
  6. healthcare data
  7. knowledge management
  8. network theory
  9. social network analysis
  10. type 2 diabetes

Qualifiers

  • Research-article

Conference

ACSW 2017
ACSW 2017: Australasian Computer Science Week 2017
January 30 - February 3, 2017
Geelong, Australia

Acceptance Rates

ACSW '17 Paper Acceptance Rate 78 of 156 submissions, 50%;
Overall Acceptance Rate 204 of 424 submissions, 48%

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • Downloads (Last 12 months)4
  • Downloads (Last 6 weeks)0
Reflects downloads up to 27 Dec 2024

Other Metrics

Citations

Cited By

View all
  • (2022)Predictive Modelling of Diseases Based on a Network and Machine Learning ApproachRecent Challenges in Intelligent Information and Database Systems10.1007/978-981-19-8234-7_50(641-654)Online publication date: 24-Nov-2022
  • (2019)Development and exploration of polymedication network from Pharmaceutical and Medicare Benefits Scheme dataProceedings of the Australasian Computer Science Week Multiconference10.1145/3290688.3290738(1-6)Online publication date: 29-Jan-2019
  • (2018)Methodology for the Design of a Student Pattern Recognition Tool to Facilitate the Teaching - Learning Process Through Knowledge Data Discovery (Big Data)Data Mining and Big Data10.1007/978-3-319-93803-5_63(670-679)Online publication date: 10-Jun-2018

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

Media

Figures

Other

Tables

Share

Share

Share this Publication link

Share on social media