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      CancerTreatmentBrain TumorHumans
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      Cognitive ScienceBrainHumansGlioma
Objective: To analyze the 3-dimensional relationships of the inferior fronto-occipital fasciculus (IFOF) within the temporal stem using anatomic dissection and to study the surgical application. Methods: Ten postmortem human hemispheres... more
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      SurgeryNeurosurgeryLanguageTemporal Lobe
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      Computed TomographyClinical TrialMagnetic Resonance ImagingDrug delivery
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      AdolescentHumansGliomaFemale
Over 80% of diffuse intrinsic pontine gliomas (DIPGs) harbor a point mutation in histone H3.3 where lysine 27 is substituted with methionine (H3.3K27M); however, how the mutation affects kinetics and function of PcG proteins remains... more
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      MultidisciplinaryHumansMutationGlioma
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      Magnetic Resonance ImagingAdolescentNeuro-OncologyHumans
The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological... more
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      CancerSurvival AnalysisMultivariate AnalysisHumans
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      Nonparametric StatisticsStatistical AnalysisNuclear medicineQuantitative analysis
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      Clinical TrialClinical NeurosciencePhotodynamic TherapyHumans
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      HumansGliomaFemaleMale
Among brain tumors, gliomas are the most common and aggressive, leading to a very short life expectancy in their highest grade. Thus, treatment planning is a key stage to improve the quality of life of oncological patients. Magnetic... more
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      EngineeringImage ProcessingMachine LearningMagnetic Resonance Imaging
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      Risk assessmentAdolescentLogistic RegressionSweden
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      Wound HealingHumansGliomaMale
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      Clinical TrialAdolescentPositron Emission TomographyProspective studies
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      Flow CytometryMitochondriaApoptosisEssential Oil
The current understanding of glioma biology reveals targets for anti-invasive therapy which include manipulations of extracellular matrix and receptors, growth factors and cytokines, proteases, cytoskeletal components, oncogenes and tumor... more
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      Comparative GenomicsForecastingExtracellular MatrixCytoskeleton
Primary low-grade gliomas are common brain tumors of childhood, many of which require radiation therapy (RT) as definitive treatment. Increased conformality of RT could decrease the incidence and severity of late effects. We report our... more
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      IntelligenceCognitionTreatment OutcomeAdolescent
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      AlgorithmsBiomedical EngineeringConfocal MicroscopyComputer Simulation
Chemokines have been involved in cellular processes associated to malignant transformation such as proliferation, migration and angiogenesis. The expression of five CXC chemokine receptors and their main ligands was analysed by RT-PCR in... more
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      NeurochemistryCell MigrationImmunohistochemistryCell Culture
OBJECT Cervicomedullary tumors (CMTs) represent a heterogeneous group of intrinsic neoplasms that are typically low grade and generally carry a good prognosis. This single-institution study was undertaken to document the outcomes and... more
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      Treatment OutcomeAdolescentBiopsyDecision Trees
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      Cognitive ScienceKineticsGene expressionBrain
The identification of signaling pathways that are involved in gliomagenesis is crucial for targeted therapy design. In this study we assessed the biological and therapeutic effect of ingenol-3-dodecanoate (IngC) on glioma. IngC exhibited... more
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      Organic ChemistryMedicinal PlantsGliomaAnticancer Drugs
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      Clinical NeuroscienceTreatment OutcomeHumansGlioma
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      Statistical AnalysisMagnetic Resonance ImagingMagnetic Resonance SpectroscopyAdolescent
Add to CiteULike Add to Complore Add to Connotea Add to Del.icio.us Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this? ... From the Odette Cancer Centre and Sunnybrook Health Sciences Centre;... more
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      Treatment OutcomeCanadaProspective studiesHumans
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      NeurochemistryDexamethasoneCell DifferentiationGlioma
Cognitive function, with survival and response on brain imaging, is increasingly regarded as an important outcome measure in patients with brain tumours. This measure provides us with information on a patient's clinical situation and... more
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      Brain ImagingRadiotherapyBrainHumans
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      BiochemistryAnalytical ChemistryKineticsMicrocirculation
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      Stem CellsCell CycleImmunohistochemistryStem Cell
As a group, children with low-grade gliomas (LGGs) enjoy a high rate of long-term survival and do not require the intensity of neurotoxic treatments used with higher risk pediatric brain tumors. Because they are generally considered to... more
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      Analytical ChemistryInorganic ChemistryOrganic ChemistryMedicinal Chemistry
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      Cancer ResearchApoptosisMedicineHumans
Cancers are one of the leading causes of morbidity and mortality worldwide, accounting for 8.8 million deaths in 2015 [1, 2]. In the US, it is estimated that 1,688,780 new cancers will be diagnosed in 2017 [3] and 600,920 people will die... more
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      Organic ChemistryCell CycleCell DivisionCell line
INTRODUCTION: Treatment recommendations for newly diagnosed anaplastic oligodendroglioma (AO) or oligo-astrocytoma (AOA) vary widely. We sought to describe actual treatment over 3 decades and explore clinical correlates of administered... more
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      ChemotherapyBrain cancerGliomaCerebral Gliomas
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      TechnologyStem CellsFlow CytometryCell Migration
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      Organic ChemistryMultiple sclerosisHumansGlioma
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      Complementary and Alternative MedicinePlant BiologyApoptosisPhytotherapy
Grade II and III gliomas are generally slowly progressing brain cancers, many of which eventually transform into more aggressive tumors. Despite recent findings of frequent mutations in IDH1 and other genes, knowledge about their... more
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      Biological SciencesHumansMutationGlioma