Herbal Extracts, Foods, and Bioactive Compounds for COVID-19 Recovery

EAS Journal of Pharmacy and Pharmacology

Objective: Coronaviruses belong to the order Nidovirales, family Coronaviridae, and four genera, namely: alpha, beta, gamma, and delta. In December 2019, a novel coronavirus was first officially reported in Wuhan City of China. Consequently, on February 11, 2020, the CSG named the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); it causes the disease dubbed Covid-19. The virus was officially declared pandemic by WHO, on March 11, 2020. Up till date, no drug, including the existing ones, has been approved for covid-19 treatment. The objective of this work, is to carry out a review on proven herbal extracts and the phyto-compound contents, for possible antiviral properties against SARS-CoV-2, and thus, as potential candidates for Covid-19 vaccine. Materials and Methods: Investigation into proven plant species against respiratory tract diseases was carried out between 1st to 30th of July, 2020 via: (a) Conduction of interview with traditional herbal healers and users...

Journal of Nephropharmacology, 2020

Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus, started in livestock within the markets of Wuhan, China and was consequently spread around the world. The virus has been rapidly spread worldwide due to the outbreak. COVID-19 is the third serious coronavirus outbreak in less than 20 years after Severe Acute Respiratory Syndrome (SARS) in 2003 and Middle East Respiratory Syndrome (MERS) in 2012. The novel virus has a nucleotide identity closer to that of the SARS coronavirus than that of the MERS coronavirus. Since there is still no vaccine, the main ways to improve personal immunity against this disease are prophylactic care and self-resistance including an increased personal hygiene, a healthy lifestyle, an adequate nutritional intake, a sufficient rest, and wearing medical masks and increasing time spent in well ventilated areas. There is a need for novel antivirals that are highly efficient and economical for the management and control of viral infections when v...

International Journal of Oral Health Dentistry, 2022

In December 2019, a novel infection called Corona virus disease (COVID-19) was first detected in Wuhan, China; caused by severe acute respiratory syndrome Corona virus 2 (SARS-CoV-2).On 11th March,2020, the World Health Organization declared COVID-19 infection a pandemic. Since then the scientific community around the world is trying to decipher this infection to control it better. We have been successful in formulating the vaccine against it in record time, but during this course, it has taken a huge toll of human lives leaving behind people who got infected with various side effects of the infection. In the absence of any definitive treatment, many alternative modes of management systems have appeared. Various herbal agents appear to have a potential role in prevention and management of this infection. In the limited time so far, several studies have been conducted which have shown positive results but also highlights their potential drawbacks with insufficient scientific evidence. This review describes the potential role of common herbal agents as possible means of management of this infection and the need of further research in this direction where these traditional and relatively safe methods could be integrated in the management schemes of various chronic infections and diseases.

Baghdad Journal of Biochemistry and Applied Biological Sciences

Background: The current outbreak of the serious respiratory syndrome disease COVID-19 has resulted from a novel coronavirus (SARS-CoV-2). This infectious disease was classified as a pandemic by the World Health Organization (WHO) because it is threatening public health and life worldwide. Recently, restrictions in many countries are applied to detect the infected individuals and isolate them, in addition to attempts to find appropriate treatments that can help decrease the severe symptoms of the disease. Regardless of the conduced efforts, the number of reported cases of coronavirus infections is still growing up. Yet, no medication or vaccine was approved to prevent and/or treat people from this coronavirus, though many researches from academic groups and medication companies are still ongoing. Objective: This review aims to summarize the possible herbs and plants from the natural herbal medicine along with western medicine, which could assist treat or protect people from COVID-19...

Journal of Pure and Applied Microbiology

Coronavirus disease (COVID) is highly contagious, and negligence of it causes high morbidity and mortality globally. The highly infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was abbreviated as COVID-19 (Coronavirus disease 2019) by World Health Organization first time on February 11, 2020, and later on, WHO declared COVID-19 as a global pandemic on 11/3/2020. Epidemiological studies demonstrated that the SARS CoV-2 infects the overall population, irrespective of age, gender, or ethnic variation, but it was observed in clinical studies that older and compromised immunity population is much more prone to COVID-19. SARS-CoV-2 majorly spread through aeration route in droplet form on sneezing and coughing, or by contact when touching eyes, nose or mouth with the infected hands or any other organs, resulting from mild to severe range of SARS-CoV-2 infection. This literature-based review was done by searching the relevant SCI and SCOPUS pap...

This review paper highlights the use of herbal medicine in the management of the coronavirus disease COVID-19 (SARS-CoV-2) pandemic, which has caused a worldwide outbreak of respiratory illness. This is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is zoonotic infecting both animal and human. Vaccines are the most promising solution to mitigate new viral strains. The Indian system of holistic medicine known as "Ayurveda" plays an important role in controling the viral disease SARS-CoV-2 and other health disorders. Dietary therapy and herbal medicine could be a complementary preventive therapy for COVID-19 (SARS-CoV-2). Plants have been used as a expression systems for the production of diagnostic reagents and pharmaceutical proteins often described as "molecular farming. On the basis of literature survy presented, some of the plant secondary metabolites that showed prominent antiviral activity against coronaviruses SARS-CoV-2 through impeding the main machinery used in their pathogenesis and replication cycle. The in vitro, in vivo, and in silico investigations revealed numerous plant-derived compounds with promising anti-SARS-CoV and anti-SARS CoV-2 activity. Therefore, this review gathered all antiviral plants in a single platform to facilitate the laboratory-based research for the development of novel drug/molecular therapeutics to overcome the SARS-CoV-2 and future pandemic situations. Further detailed clinical trial experiments should be conducted for the scientific validation.

Universal Journal of Pharmaceutical Research, 2020

Coronavirus pneumonia disease (COVID-19) is a newly identified coronavirus strain that causes symptoms ranging from cold-like signs to deaths that reached millions around the world. Until this time, there is no approved vaccine has been invented for clinical use, therefore, developing an effective program for therapy is of high priority to save the lives of patients and protect others from being infected. Nature resembles a huge reservoir of anti-infectious compounds, from which innovative ideas, therapies, and products can be deduced. Chinese herbal medicine had succeeded in the treatment of other coronavirus pneumonia such as SARS, MERS and, H7N9 avian influenza which gives us hope to find the targeted remedy in the traditionally used natural herbs consumed by natives from different regions. This work aims to highlight the use of natural traditional remedies to treat viral pneumonia. This systematic review will include studies of the effects of traditional herbal medicine and its role in the treatment of COVID-19 pneumonia. Although promising results were obtained in many cases, but, only a few studies reported the fractional characterization of bioactive principles and/or mechanisms of action. It is requested that pharmaceutical industries, government agencies, and the scientific community will have a gaze at some of these plants for future research and, to find a potential drug candidates for the development of anti-SARSCoV-2 therapeutics in the near future.

Journal of Natural Remedies

Background: Since December 2019, severe acute respiratory syndrome coronavirus to developing severe acute respiratory disease originated from Wuhan, China, and further spread rapidly all over the world except very few counties. On 30th January 2020, The WHO confirmed the epidemic as a community health crisis all over world. No drug was approved for treatment but some conventional and traditional medicinal plants are being used against COVID-19 infections. Objective: The present review is to illustrate current updates on conventional and traditional herbal medicine used for deterrent and treatment of SARS-CoV-2 infection. Methods: Search engines like Scopus, Pubmed, and World Health Organization (WHO) literature on current advances about novel coronavirus (COVID-19) were reviewed. Discussion and Conclusion: Current research data indicated that the outbreaks caused by SARS MERS and COVID-19 have produced substantial community health problems. Currently, there are no vaccines for preve...

Vegetos, 2023

This review paper highlights the use of herbal medicine in the management of the coronavirus disease COVID-19 (SARS-CoV-2) pandemic, which has caused a worldwide outbreak of respiratory illness. This is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is zoonotic infecting both animal and human. Vaccines are the most promising solution to mitigate new viral strains. The Indian system of holistic medicine known as "Ayurveda" plays an