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Abstracts EAU20 Virtual Congress and Theme Week 488 Is the type of xenograft relevant for patient’s satisfaction after surgical treatment of Peyronie’s disease? A single-center experience Eur Urol Open Sci 2020;19(Suppl 2):e763 Fiorillo A.1, Bianchi L.1, Droghetti M.1, Sadini P.1, Masetti M.1, Piazza P.1, Gentile G.2, Vagnoni V.2, Franceschelli A.2, Colombo F.2 1 S.Orsola-Malpighi University Hospital, University of Bologna, Dept. of Urology, Bologna, Italy, 2University Hospital of S. Orsola, Andrology Unit - Dept of Urology and Gynecology, Bologna, Italy Introduction & Objectives: Surgical treatment for Peyronie’s disease (PD) includes albugineal grafting with xenografts after plaque incision/ excision (PEG). The aim of this study is to compare two different types of xenograft (porcine acellular collagen matrix vs bovine pericardium collagen matrix) assessing functional outcomes and patients’ satisfaction. Materials & Methods: From 2010 to 2019, 63 patients with PD underwent corporoplasty with PEG at single tertiary center, using two different xenografts: Porcine acellular collagen matrix (25 patients - Group1) and bovine pericardium collagen matrix (38 patients – Group2). For long-term evaluation of surgical outcomes multi-disciplinary questionnaires were administered, by phone interview, performed by the same physician. Overall, 53 patients completed the follow up (19 in Group 1 and 34 in Group 2). The following items were considered: Correction of penile bending, quality of erection, ability to intercourse, penile shortening, sensitiveness. The overall satisfaction and the impact of the intervention on the sexual activity and quality of life were also investigated. Results: Mean patients age at time of surgery was 56 years, mean follow up was 85 months for Group 1 and 32 months for Group 2 (p value 0.1). The 2 groups were homogeneous in terms of co-morbidity and types of curvature. Plaque median size was 27.5 mm (Group 1) and 31 mm (Group 2). Considering that no patient complained significant preoperative erectile dysfunction (DE), we found significant erectile dysfunction (overall value < 17 of the International Index of erectile Function - IIEF-5) in 37.7% of patients (p value 0.4). Complete straightening of the penis was obtained in 73.7% (Group 1) and 76.5% (Group 2). Penile shortening occurred in 15 patients in Group 1 (78.9%) and in 27 in Group 2 (79.4%) (p value 0.8) Only 4 major short-term complications were observed: 2 infections,1 bleeding and ischemia of the glans. Patients' post-operative sexual life was reported as improved in 47.4% of cases in G1 and in 47.1% of cases in Group 2, unchanged in 9 patients in Group 1 (47.4%) and in 10 patients in G2 (29.4%), worsened in 1 patient in Group 1 (5.3%) and in 8 patients in G2 (23.5%). Conclusions: Corporoplasty with PEG is a safe procedure and no statistically significant differences were found between porcine acellular collagen matrix and bovine pericardium collagen matrix, in terms of surgical outcomes and overall patients' satisfaction. Eur Urol Open Sci 2020;19(Suppl 2):e763