TNP1

TNP1
Identifiers
Aliases	TNP1 , TP1, transition protein 1
External IDs	OMIM: 190231 MGI: 98784 HomoloGene: 136517 GeneCards: TNP1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,860,064 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	73,055,068 bp
RNA expression pattern
	Top expressed in
	sperm; ; cerebellar vermis; ; caput epididymis; ; corpus epididymis; ; right coronary artery; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right uterine tube; ; canal of the cervix; ; right lobe of liver;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; entorhinal cortex; ; interventricular septum; ; plantaris muscle; ; extensor digitorum longus muscle; ; corneal stroma; ; morula; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein binding ;
Cellular component	male germ cell nucleus ; nucleosome ; chromosome ; nucleus ;
Biological process	multicellular organism development ; single strand break repair ; flagellated sperm motility ; chromatin remodeling ; spermatid nucleus differentiation ; cell differentiation ; spermatid nucleus elongation ; nucleosome disassembly ; negative regulation of transcription, DNA-templated ; sexual reproduction ; spermatogenesis ; spermatid development ; positive regulation of protein processing ;
	Sources:Amigo / QuickGO
Orthologs
	7141
	21958
	ENSG00000118245
	ENSMUSG00000026182
	P09430
	P10856
	NM_003284
	NM_009407
	NP_003275
	NP_033433
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 17, 2023

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000118245 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026182 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics. 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
↑ "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis". Chromosoma. 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712. S2CID 28866607.
Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants" (PDF). Eur. J. Biochem. 198 (1): 13–20. doi: 10.1111/j.1432-1033.1991.tb15980.x . PMID 2040274.
Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J. Biol. Chem. 265 (34): 21039–47. doi: 10.1016/S0021-9258(17)45324-5 . PMID 2250010.
Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1". Biochim. Biophys. Acta. 950 (2): 215–20. doi:10.1016/0167-4781(88)90013-9. PMID 3382664.
Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445 . PMID 3412903.
Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. Bibcode:2000PNAS...97.4683Y. doi: 10.1073/pnas.97.9.4683 . PMC 18293 . PMID 10781074.
Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids". Italian Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia. 103 (4 Suppl 1): 65–74. PMID 11315969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi: 10.2164/jandrol.05069 . PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000118245 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026182 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2249851-5] Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics. 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.

[entrez-6] "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

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TNP1

Related Research Articles

References

Further reading