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Alliance for Aging Research, in collaboration with Milliman, has developed the Standard of Living Valuation framework to offers a more equitable, real-world alternative to #QALYs, focusing on #socioeconomic factors to assess healthcare value. Read at The Evidence Base® #heor #healtheconomics #outcomesresearch #rwe #rwd #realworldevidence #realworlddata #marketaccess #medicalaffairs #hta #healthtechnologyassessment #healthdata #healthequity #healthpolicy #socialdeterminantsofhealth

Catch up on our picks of the latest peer-reviewed content from August 2024 across the spectrum of #RWE and #HTA. This month, featuring: - The maze of real-world evidence frameworks: from a desert to a jungle! An environmental scan and comparison across regulatory and health technology assessment agencies. Grammati Sarri & Luis Hernandez. - Contemporary practice and considerations for real-world data source identification and feasibility assessment. Dony Patel, Sonia G., Lina Titievsky, Susanna Flaherty, Nicholas Everage, PhD, Marta Korjagina (IQVIA), Sheuli Porkess, Tzuyung Douglas Kou, PhD, MPH, MA. & Deborah Layton. - Real-world evidence to support regulatory submissions: A landscape review and assessment of use cases. Golnoosh Alipour-Haris, Olivia (Xinyue) L., Virginia Acha, Almut Winterstein & Mehmet Burcu. - Leveraging real-world data in safety signal assessment. Vaishali Patadia, Katrin Manlik, Geoffrey Gipson, Jenna Willis, Ruth Namuyinga, Rachel McDermott, Anita Shaw, Mary Miller, Julius Asubonteng, Negar Golchin & Stephanie von Klot - Lessons on the use of real-world data in medical device research: findings from the National Evaluation System for Health Technology Test-Cases. Justin Timbie, Alice Kim, Lawrence Baker, Rosemary Li & Thomas Concannon - Linking clinical trial participants to their U.S. real-world data through tokenization: A practical guide. Michael Eckrote, Carrie M. Nielson, Mike L., Tyler Alexander, Rikisha G., Kim Wah Low, Zhiwei Zhang, PhD, FASA, Austin Eliazar, Reyna Klesh, Andrew Kress, Matt Bryant, Alex Asiimwe, Nicolle M Gatto & Nancy A. Dreyer - Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Lessons Learnt From the MINERVA Project in Europe. Rosa Gini, Romin Pajouheshnia, Lia Gutierrez Cornejo et al. - Integrating price benchmarks and comparative clinical effectiveness to inform the Medicare Drug Price Negotiation Program. Sean Sullivan, Olivier Wouters, Emma Cousin, Ayuri Kirihennedige & Inmaculada (Inma) Hernandez Read at The Evidence Base® #heor #healtheconomics #outcomesresearch #rwe #rwd #realworldevidence #realworlddata #marketaccess #pharma #biopharma #medicalaffairs #regulation #regulatoryaffairs #hta #healthtechnologyassessment #healthdata #healthequity #healthpolicy

A new pioneering project, led by researchers from The University of Edinburgh and University of Dundee, is leveraging AI to predict an individual’s risk of developing dementia through the analysis of brain scans. This initiative, known as the Scottish AI in Neuroimaging to predict Dementia and Neurodegenerative Disease (SCAN-DAN), is part of the broader NEURii collaboration, which seeks to transform neurology and digital sciences into practical healthcare solutions. Read at The Evidence Base® https://lnkd.in/eAWMSK3J

NICE - National Institute for Health and Care Excellence releases guidance on integrating #AI into real-world evidence generation. New guidance from #NICE emphasizes transparency, rigorous validation and human oversight to ensure ethical, accurate health technology assessments. Read more The Evidence Base® #RWE #RealWorldEvidence #RWD #HTA https://lnkd.in/etcqZ7EW

In this week's round-up from The Evidence Base®:   After much speculation and conjecture, the US government has unveiled the pricing for the first batch of drugs selected for Medicare drug price negotiations mandated under the #InflationReductionAct. Read about this latest development, along with resharing some of our previous content on this evolving topic.   Read our interview with Shirley V Wang (Brigham and Women's Hospital, Harvard Medical School) and Anton Pottegård (Syddansk Universitet - University of Southern Denmark) discussing their latest publication, "Building transparency and reproducibility into the practice of #pharmacoepidemiology and outcomes research".   Check out this Peek Behind the Paper interview with Ashley Jaksa and Patrick Arena (Aetion) discussing the availability of comparative #RWE in #Medicare patients, and the implications for #CMS drug price negotiations.   Read our Guest Column from Kistein Monkhouse, MPA (Patient Orator ) and Jason Spangler (Center for Innovation & Value Research) underscoring the importance of meaningful patient engagement during the implementation of the #IRA.   Don't forget to sign up to our #webinars, including:   - Introducing the #ROPAD consortium: unlocking real-world genetic insights to accelerate treatment access for Parkinson’s disease, September 24, 10:30an ET (CENTOGENE)   Plus, new articles from the Journal of Comparative Effectiveness Research on #RWD in #MedicalDevices research, comparative efficacy of treatments for #MultipleSclerosis, and treatments of #MultipleMyeloma.

📣Meet our Editor at the 2024 ISPE Annual Meeting!   The Evidence Base's Laura Dormer, will be attending the 2024 International Society for Pharmacoepidemiology (ISPE) Annual Meeting at the Estrel Congress Center, Berlin, Germany from 24-28 August 2024.   Laura is looking forward to connecting with other attendees, and discussing the latest advancements in pharmacoepidemiology, outcomes research and real-world evidence.   Be sure to connect with Laura and reach out if you would like to meet up! https://lnkd.in/eUXanmYh #ISPEAnnual2024 #ISPE #Pharmacoepidemiology #RWE #TheEvidenceBase

Yesterday's announcement from CMS regarding the prices of drugs selected under the #InflationReductionAct has been the topic of much discussion over the past 24 hours. In my latest article on The Evidence Base®, I delve into the details of this announcement, exploring the ongoing debates around transparency and the potential impact on patient access, and highlighting what this could mean for the future of the biopharma sector. Read on The Evidence Base®: https://lnkd.in/eMGhVvtJ Kimberly Westrich Brian Reid John O'Brien Inmaculada (Inma) Hernandez Sean Sullivan

On the eve of the second anniversary of the enactment of the Inflation Reduction Act and with the first round of final “negotiated” drug prices expected any day now, anticipation is building across the healthcare landscape. Stakeholders - from patients and advocacy groups to pharmaceutical companies and policymakers - are continuing to speculate about how the IRA's reforms will impact access to medications, industry profitability, and the broader goals of reducing healthcare costs. In our latest interview, we speak with William Sarraille, a rare disease patient who writes and speaks often on patient access issues, to gain insights into how the IRA may influence patient care and the broader healthcare landscape. #DrugPricing #InflationReductionAct #IRA #MarketAccess Read at The Evidence Base®:

Watch the latest episode of ‘Patti’s People, with Patti Peeples, PhD of the The Peeples Collaborative. In this episode, Patti speaks with Blythe Adamson, PhD, MPH, Head of Outcomes Research, Flatiron Health. Watch at The Evidence Base® #heor #healtheconomics #outcomesresearch #rwe #rwd #realworldevidence #realworlddata #marketaccess #hta #healthtechnologyassessment #healthdata #healthequity #socialdeterminantsofhealth #electronichealthrecords #EHRs #SDOH #inflationreductionact

#RealWorldData study confirms lower incidence of #heartattacks and #strokes after #COVID19 #vaccination The study of nearly 46 million adults in England published in Nature Communications sheds light on the #cardiovascular safety of different vaccination doses, and supports the continued use of COVID-19 vaccines as a critical component of #publichealthstrategies. Read at The Evidence Base® #heor #healtheconomics #outcomesresearch #rwe #rwd #realworldevidence #healthdata #healthpolicy