Kidney International aims to inform the renal researcher and practicing nephrologists on all aspe... more Kidney International aims to inform the renal researcher and practicing nephrologists on all aspects of renal research. Clinical and basic renal research, commentaries, The Renal Consult, Nephrology sans Frontieres, minireviews, reviews, Nephrology Images, Journal Club. Published ...
Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Brazil is a continental country with great diversity of population, social and cultural. This fac... more Brazil is a continental country with great diversity of population, social and cultural. This factor may determine different demographic, clinical and outcome presented by patients with chronic kidney disease on peritoneal dialysis (PD). To evaluate the clinical characteristics and outcomes presented by PD patients in different regions of Brazil, analyzing a cohort of patients (BRAZPD) in the period 12/2004 to 10/2007. Data were collected monthly and patients were followed until the outcome (death, renal transplantation, renal function recovery, transfer to hemodialysis or loss of follow-up). We evaluated 5.819 patients incident and prevalent. Most patients performed renal replacement therapy (RRT) in the Southeast, where the average follow up time was longer (12.3 months) and there is a higher percentage of elderly (36.4%). The prevalence of diabetes is higher in Southeast and South (38.1% and 37%, respectively). Most patients in the North region had previously hemodialysis (66.2%)...
ABSTRACT Introduction: One aim of evidence based learning is to establish guidelines to reach goa... more ABSTRACT Introduction: One aim of evidence based learning is to establish guidelines to reach goals obtained from clinical evidences. Reconciliation of guidelines is desired, however, adaptations should be made for the reality of each country. AIM: To assess the degree of adherence to the therapeutic recommendations proposed by the Spanish dialysis guidelines in a cohort of Brazilian patients on peritoneal dialysis (PD). Patients and Methods: A descriptive, cross- sectional study was performed in prevalent and incident patients on PD (BRAZPD) enrolled between December of 2004 and February of 2007, and followed for >3 months. Demographic, clinical and laboratorial data were assessed using electronic medical records. Results: A total of 3,226 patients were assessed, 2,094 of them were incident, observed for a mean time of 13.6 months. The mean age was 54±19 years (34% were over 65 years), 55% were female, and 64% were white. The main etiology of CKD was diabetic nephropathy (34%), ...
Urinary tract infection (UTI) is a common complication among kidney transplant patients. UTI caus... more Urinary tract infection (UTI) is a common complication among kidney transplant patients. UTI caused by multi-resistant extended-spectrum beta-lactamase producing bacteria (ESBL) have largely increased among the hospitalized patient population and especially kidney transplant recipients. We retrospectively studied 83 kidney transplant patients to evaluate the incidence and possible causative conditions of ESBL-related UTI over the last 6 years. ESBL production was determined by the antibiotic susceptibility profile of urine cultures. We compared the incidence in two 3-year periods, 2003-2005 (period 1) and 2006-2008 (period 2). An high incidence of ESBL-related UTI (16.8%) was observed in the posttransplant period performing 31% of the overall UTI incidence, with an increase over the last 3 years from 23.8% to 37.5%. ESBL-related UTI was related to previous episodes of UTI (78.6% vs 29.0%; P < .01) and reoperations (50.0% vs 12.9%; P < .05). We observed a progressively increasing incidence of 13%, 38%, and 45% of ESBL-related UTI among first, second, and third episodes, respectively. Age, gender, HLA mismatches, etiology of chronic kidney disease, diabetes mellitus, acute rejection, induction treatment, and type/level of immunosuppressants were similiar between the groups with or without ESBL-related UTI. We observed a high increased incidence of ESBL-related UTI among kidney transplant recipients, and particularly patients with recurrent UTI.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 2014
Introduction: Nowadays it is described a high prevalence of hypovitaminosis D in Systemic Lupus E... more Introduction: Nowadays it is described a high prevalence of hypovitaminosis D in Systemic Lupus Erythematosus (SLE), which is associated with some clinical manifestations and increased inflammatory activity. Objective: To evaluate the association between vitamin D insufficiency with SLE and inflammatory markers. Methods: Cross-sectional study, in which have been evaluated 45 SLE patients and 24 controls without the disease. Levels of 25-hydroxyvitamin D [25(OH) D] less than 30 ng/mL were considered inadequate. Disease activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). High sensitivity C reactive protein (hsCRP) and interleukin-6 (IL-6) were evaluated for verification of the inflammatory status. For assessment of renal involvement, analysis of abnormal elements and urinay sediment (AES), quantitative hematuria and pyuria, proteinuria and creatinine clearance in 24-hour urine and serum anti-double stranded DNA were performed. Results: The preval...
To determine the roles of body size and longitudinal body weight changes in the survival of incid... more To determine the roles of body size and longitudinal body weight changes in the survival of incident peritoneal dialysis patients. Patients (n = 1911) older than 18 years of age recruited from 114 dialysis centers (Dec/ 2004-Oct/2007) and participating in the Brazilian Peritoneal Dialysis Multicenter Cohort Study were included. Clinical and laboratory data were collected monthly (except if the patient received a transplant, recovered renal function, was transferred to hemodialysis, or died). Survival analyses were performed using Kaplan-Meier survival curves and Cox proportional hazards. Total follow-up was 34 months. The mean age was 59 years (54% female). The weight category percentages were as follows: underweight: 8%; normal: 51%; overweight: 29%; and obese 12%. The multivariate model showed a higher risk of death for a body mass index <18.5 kg/m², a neutral risk between 25 and 29.9 kg/m² and a protective effect for an index >30 kg/m². Patients were divided into five categ...
Kidney International aims to inform the renal researcher and practicing nephrologists on all aspe... more Kidney International aims to inform the renal researcher and practicing nephrologists on all aspects of renal research. Clinical and basic renal research, commentaries, The Renal Consult, Nephrology sans Frontieres, minireviews, reviews, Nephrology Images, Journal Club. Published ...
Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Brazil is a continental country with great diversity of population, social and cultural. This fac... more Brazil is a continental country with great diversity of population, social and cultural. This factor may determine different demographic, clinical and outcome presented by patients with chronic kidney disease on peritoneal dialysis (PD). To evaluate the clinical characteristics and outcomes presented by PD patients in different regions of Brazil, analyzing a cohort of patients (BRAZPD) in the period 12/2004 to 10/2007. Data were collected monthly and patients were followed until the outcome (death, renal transplantation, renal function recovery, transfer to hemodialysis or loss of follow-up). We evaluated 5.819 patients incident and prevalent. Most patients performed renal replacement therapy (RRT) in the Southeast, where the average follow up time was longer (12.3 months) and there is a higher percentage of elderly (36.4%). The prevalence of diabetes is higher in Southeast and South (38.1% and 37%, respectively). Most patients in the North region had previously hemodialysis (66.2%)...
ABSTRACT Introduction: One aim of evidence based learning is to establish guidelines to reach goa... more ABSTRACT Introduction: One aim of evidence based learning is to establish guidelines to reach goals obtained from clinical evidences. Reconciliation of guidelines is desired, however, adaptations should be made for the reality of each country. AIM: To assess the degree of adherence to the therapeutic recommendations proposed by the Spanish dialysis guidelines in a cohort of Brazilian patients on peritoneal dialysis (PD). Patients and Methods: A descriptive, cross- sectional study was performed in prevalent and incident patients on PD (BRAZPD) enrolled between December of 2004 and February of 2007, and followed for >3 months. Demographic, clinical and laboratorial data were assessed using electronic medical records. Results: A total of 3,226 patients were assessed, 2,094 of them were incident, observed for a mean time of 13.6 months. The mean age was 54±19 years (34% were over 65 years), 55% were female, and 64% were white. The main etiology of CKD was diabetic nephropathy (34%), ...
Urinary tract infection (UTI) is a common complication among kidney transplant patients. UTI caus... more Urinary tract infection (UTI) is a common complication among kidney transplant patients. UTI caused by multi-resistant extended-spectrum beta-lactamase producing bacteria (ESBL) have largely increased among the hospitalized patient population and especially kidney transplant recipients. We retrospectively studied 83 kidney transplant patients to evaluate the incidence and possible causative conditions of ESBL-related UTI over the last 6 years. ESBL production was determined by the antibiotic susceptibility profile of urine cultures. We compared the incidence in two 3-year periods, 2003-2005 (period 1) and 2006-2008 (period 2). An high incidence of ESBL-related UTI (16.8%) was observed in the posttransplant period performing 31% of the overall UTI incidence, with an increase over the last 3 years from 23.8% to 37.5%. ESBL-related UTI was related to previous episodes of UTI (78.6% vs 29.0%; P &lt; .01) and reoperations (50.0% vs 12.9%; P &lt; .05). We observed a progressively increasing incidence of 13%, 38%, and 45% of ESBL-related UTI among first, second, and third episodes, respectively. Age, gender, HLA mismatches, etiology of chronic kidney disease, diabetes mellitus, acute rejection, induction treatment, and type/level of immunosuppressants were similiar between the groups with or without ESBL-related UTI. We observed a high increased incidence of ESBL-related UTI among kidney transplant recipients, and particularly patients with recurrent UTI.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 2014
Introduction: Nowadays it is described a high prevalence of hypovitaminosis D in Systemic Lupus E... more Introduction: Nowadays it is described a high prevalence of hypovitaminosis D in Systemic Lupus Erythematosus (SLE), which is associated with some clinical manifestations and increased inflammatory activity. Objective: To evaluate the association between vitamin D insufficiency with SLE and inflammatory markers. Methods: Cross-sectional study, in which have been evaluated 45 SLE patients and 24 controls without the disease. Levels of 25-hydroxyvitamin D [25(OH) D] less than 30 ng/mL were considered inadequate. Disease activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). High sensitivity C reactive protein (hsCRP) and interleukin-6 (IL-6) were evaluated for verification of the inflammatory status. For assessment of renal involvement, analysis of abnormal elements and urinay sediment (AES), quantitative hematuria and pyuria, proteinuria and creatinine clearance in 24-hour urine and serum anti-double stranded DNA were performed. Results: The preval...
To determine the roles of body size and longitudinal body weight changes in the survival of incid... more To determine the roles of body size and longitudinal body weight changes in the survival of incident peritoneal dialysis patients. Patients (n = 1911) older than 18 years of age recruited from 114 dialysis centers (Dec/ 2004-Oct/2007) and participating in the Brazilian Peritoneal Dialysis Multicenter Cohort Study were included. Clinical and laboratory data were collected monthly (except if the patient received a transplant, recovered renal function, was transferred to hemodialysis, or died). Survival analyses were performed using Kaplan-Meier survival curves and Cox proportional hazards. Total follow-up was 34 months. The mean age was 59 years (54% female). The weight category percentages were as follows: underweight: 8%; normal: 51%; overweight: 29%; and obese 12%. The multivariate model showed a higher risk of death for a body mass index <18.5 kg/m², a neutral risk between 25 and 29.9 kg/m² and a protective effect for an index >30 kg/m². Patients were divided into five categ...
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