N-Acetilaspartinska kiselina
Изглед
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Nazivi | |
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IUPAC naziv
2-Acetamidobutandioinska kiselina[1]
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Identifikacija | |
3D model (Jmol)
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3DMet | B00227 |
Bajlštajn | 1726198 S |
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.012.403 |
EC broj | 219-827-5 |
KEGG[2] | |
MeSH | N-acetylaspartate |
RTECS | CI9098600 |
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Svojstva | |
C6H9NO5 | |
Molarna masa | 175,14 g·mol−1 |
Agregatno stanje | Bezbojni, transparentni kristali |
log P | −2.209 |
Kiselost (pKa) | 3.142 |
Baznost (pKb) | 10.855 |
Opasnosti | |
S-oznake | S22, S24/25 |
Srodna jedinjenja | |
Srodne alkanoinske kiseline
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Srodna jedinjenja
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
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Reference infokutije | |
N-Acetilaspartic acid (N-acetilaspartat, NAA) je derivat aspartinske kiseline sa formulom C6H9NO5 i molekulskom težinom 175,139.
NAA je drugi po zastupljenosti neurotransmiter u mozgu, posle glutamatne aminokiseline. On je prisutan u mozgu odraslih osoba jedino u neuronima.[5] Sintetiše se u mitochondrijama[6] iz aspartinske kiseline i acetil-koenzimA A.
Reference
[уреди | уреди извор]- ^ „N-acetylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005. Identification. Приступљено 8. 1. 2012.
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991
- ^ Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.
Literatura
[уреди | уреди извор]- N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
- Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; . doi:10.1523/JNEUROSCI.0588-09.2009. Недостаје или је празан параметар
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