Mepakrin
Mepakrin je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 399,957 Da.[1][2][3][4][5][6][7]
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Acrichine, Acrinamine, Acriquine, Akrichin |
| Drugs.com | Monografija |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 5 - 14 dana |
| Identifikatori | |
| CAS broj | 83-89-6  |
| ATC kod | None |
| PubChem | CID 237 |
| DrugBank | DB01103 |
| ChemSpider | 232 |
| KEGG | C07339 |
| ChEBI | CHEBI:8711 |
| ChEMBL | CHEMBL7568 |
| Hemijski podaci | |
| Formula | C23H30ClN3O |
| Molarna masa | 399,957 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | 248—250 °C (478—482 °F) |
Osobine
уреди| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 9 |
| Particioni koeficijent[8] (ALogP) | 5,7 |
| Rastvorljivost[9] (logS, log(mol/L)) | -7,6 |
| Polarna površina[10] (PSA, Å2) | 37,4 |
Reference
уреди- ^ Canete, R.; Escobedo, A. A.; Gonzalez, M. E.; Almirall, P. (2006). „Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children”. World Journal of Gastroenterology. 12 (39): 6366—70. PMC 4088148
. PMID 17072963. doi:10.3748/wjg.v12.i39.6366 .
- ^ Toubi, E.; Kessel, A.; Rosner, I.; Rozenbaum, M.; Paran, D.; Shoenfeld, Y. (април 2006). „The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus”. Scandinavian Journal of Immunology. 63 (4): 299—303. PMID 16623930. S2CID 40984831. doi:10.1111/j.1365-3083.2006.01737.x.
- ^ Zipper, J.; Cole, L. P.; Goldsmith, A.; Wheeler, R.; Rivera, M. (1980). „Quinacrine hydrochloride pellets: Preliminary data on a nonsurgical method of female sterilization”. International Journal of Gynecology & Obstetrics. 18 (4): 275—9. PMID 6109672. S2CID 41946631. doi:10.1002/j.1879-3479.1980.tb00496.x.
- ^ Bhatt, R. V. (децембар 1991). „Camp laparoscopic sterilization deaths in Gujarat State, India, 1978-1980”. Asia-Oceania Journal of Obstetrics and Gynaecology. 17 (4): 297—301. PMID 1839351. doi:10.1111/j.1447-0756.1991.tb00277.x.
- ^ Peterson, H.B.; Lubell, I.; Destefano, F.; Ory, H.W. (април 1983). „The safety and efficacy of tubal sterilization: An international overview”. International Journal of Gynecology & Obstetrics. 21 (2): 139—44. PMID 6136433. S2CID 15179539. doi:10.1016/0020-7292(83)90051-6.
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
уреди- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
