Galmik

Galmik
Identifikatori
PubChem	CID 11636593
ChEMBL	CHEMBL578918
Hemijski podaci
Formula	C51H60N10O11
Molarna masa	989,080
	SMILES c7cccc3c7-c4ccccc4C3NC(=O)C(C)(c(oc6C)nc6C(=O)NC2(C)C(=O)NC(C(=O)OC)CCCCN)NC(=O)c1nc(oc1C)C(C)(NC(=O)c5nc2oc5C)C(=O)NCC8CCCCC8; ;

Galmik je lek koji deluje kao selektivni, ne-peptidni agonist galaninskih receptora.^[1] On je pokazao antiepileptičke, antidepresivne i analgetske efekte u životinjskim studijama,^[2] ali isto tako inhibira memorijske funkcije.^[3]

Literatura

^ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (2004). „Synthesis of galmic: a nonpeptide galanin receptor agonist”. Proceedings of the National Academy of Sciences of the United States of America. 101 (48): 16727—32. PMC 534730  . PMID 15557002. doi:10.1073/pnas.0407543101.
^ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (2004). „Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests”. Proceedings of the National Academy of Sciences of the United States of America. 101 (28): 10470—5. PMC 478593  . PMID 15240875. doi:10.1073/pnas.0403802101.
^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (2005). „Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice”. Neuropeptides. 39 (3): 249—51. PMID 15944018. doi:10.1016/j.npep.2004.12.010.

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