GPRC6A
G protein spregnuti receptor familija C group 6 član A je protein koji je kod ljudi kodiran GPRC6A genom.[1] Ovaj receptor funkcioniše kao senzor L-aminokiselina,[2] osteokalcina,[3] i steroida.[4]
| G protein spregnuti receptor, familija C, grupa 6, član A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPRC6A; GPCR; bA86F4.3 | ||||||||||
| Vanjski ID | OMIM: 613572 MGI: 2429498 HomoloGene: 17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 222545 | 210198 | |||||||||
| Ensembl | ENSG00000173612 | ENSMUSG00000019905 | |||||||||
| UniProt | Q5T6X5 | Q8K4Z6 | |||||||||
| RefSeq (mRNA) | NM_148963.2 | NM_153071.1 | |||||||||
| RefSeq (protein) | NP_683766.2 | NP_694711.1 | |||||||||
| Lokacija (UCSC) |
Chr 6: 117.11 - 117.15 Mb |
Chr 10: 51.33 - 51.35 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Klinički značaj
уредиGPRC6A je takođe povezan sa progresijom raka prostate, i pokazano je da posreduje brz, negenomiski respons ćelija kancera prostate na testosteron.[5]
Reference
уреди- ^ „Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A”.
- ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589—97. PMID 15576628. doi:10.1124/mol.104.007559.
- ^ Pi M, Wu Y, Quarles LD (2011). „GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo”. J. Bone Miner. Res. 26 (7): 1680—3. PMID 21425331. doi:10.1002/jbmr.390.
- ^ Pi M, Parrill AL, Quarles LD (2010). „GPRC6A mediates the non-genomic effects of steroids”. J. Biol. Chem. 285 (51): 39953—64. PMID 20947496. doi:10.1074/jbc.M110.158063.
- ^ Pi M, Quarles LD (2011). „GPRC6A regulates prostate cancer progression”. Prostate. 72 (4): 399—409. PMID 21681779. doi:10.1002/pros.21442.
Literatura
уреди- Harrington JJ; Sherf B; Rundlett S; et al. (2001). „Creation of genome-wide protein expression libraries using random activation of gene expression.”. Nat. Biotechnol. 19 (5): 440—5. PMID 11329013. doi:10.1038/88107.
- Takeda S; Kadowaki S; Haga T; et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97—101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8.
- Mungall AJ; Palmer SA; Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055.
- Wellendorph P, Bräuner-Osborne H (2004). „Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor”. Gene. 335: 37—46. PMID 15194188. doi:10.1016/j.gene.2004.03.003.
- Wellendorph P; Hansen KB; Balsgaard A; et al. (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589—97. PMID 15576628. doi:10.1124/mol.104.007559.
- Pi M; Faber P; Ekema G; et al. (2006). „Identification of a novel extracellular cation-sensing G-protein-coupled receptor”. J. Biol. Chem. 280 (48): 40201—9. PMC 1435382
. PMID 16199532. doi:10.1074/jbc.M505186200.
Spoljašnje veze
уреди- GPRC6A+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
- „Calcium-Sensing Receptors: GPRC6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.