Heterocycles are of immense importance in the design and discovery of new compounds for pharmaceu... more Heterocycles are of immense importance in the design and discovery of new compounds for pharmaceutical applications. 1 The 2H-1-benzothiopyran (thiochromenes) group is an important structural motif in the preparation ...
In the realm of organocatalysis, many efforts have been devoted in the past few years to the enan... more In the realm of organocatalysis, many efforts have been devoted in the past few years to the enantioselective synthesis of fluorine-containing compounds using aldehydes as the starting materials. The most common way relies on the use of electrophilic fluorine sources: for example, the ...
Heterocycles are of immense importance in the design and discovery of new compounds for pharmaceu... more Heterocycles are of immense importance in the design and discovery of new compounds for pharmaceutical applications. 1 The 2H-1-benzothiopyran (thiochromenes) group is an important structural motif in the preparation ...
In the realm of organocatalysis, many efforts have been devoted in the past few years to the enan... more In the realm of organocatalysis, many efforts have been devoted in the past few years to the enantioselective synthesis of fluorine-containing compounds using aldehydes as the starting materials. The most common way relies on the use of electrophilic fluorine sources: for example, the ...
The selective introduction of fluorine (or of fluorine-bearing building blocks) into organic mole... more The selective introduction of fluorine (or of fluorine-bearing building blocks) into organic molecules and polymers can dramatically alter their physical, chemical and biological properties. Thus, the unique behavior exhibited by many organofluorinated synthetic compounds has ...
In the field of organocatalysis, reactions that involve a combination of catalytic iminium and en... more In the field of organocatalysis, reactions that involve a combination of catalytic iminium and enamine intermediates have been developed recently.1214 On the basis of this research and our previous experience in the combination of catalytic cycles,15 we envisaged that a reaction ...
The first highly diastereo- and enantioselective organocatalytic synthesis of 2,2-disubstituted-2... more The first highly diastereo- and enantioselective organocatalytic synthesis of 2,2-disubstituted-2H-oxazol-5-ones is described. The addition of oxazolones to maleimides is promoted by bifunctional thiourea catalysts, which afford the corresponding 2,2-disubstituted-2H-oxazol-5-ones with total regio- and stereocontrol.
We found that protected diphenylprolinol 5 11 and (S)-proline 7 catalyzed the asymmetric formatio... more We found that protected diphenylprolinol 5 11 and (S)-proline 7 catalyzed the asymmetric formation of the trisubstituted cyclopentanones 3a and ent-3a, respectively, in high yields with 97 and −53% ee, respectively (entries 2 ...
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