Mukrolizin
| Mukrolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.54 | ||||||||
| CAS broj | 85898-38-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mukrolizin (EC 3.4.24.54, Trimeresurus metaloendopeptidaza A, mukrotoksin A) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Ser9-His, His10-Leu, Ala14-Leu, Leu15-Tyr i Tyr16-Leu veza u lancu insulina B
Ova hemoragična i fibrinogenolitička endopeptidaza je prisutana u venumu zmije Trimeresurus mucrosquamatus.
- ↑ Sugihara, H., Moriura, M. and Nikai, T. (1983). „P'urification and properties of a lethal, hemorrhagic protein, "mucrotoxin A", from the venom of the Chinese habu snake (Trimeresurus mucrosquamatus)”. Toxicon 21: 247-255. PMID 6857709.
- ↑ Kishida, M., Nikai, T., Mori, N., Kohmura, S. and Sugihara, H. (1985). „Characterization of mucrotoxin A from the venom of Trimeresurus mucrosquamatus (the Chinese habu snake)”. Toxicon 23: 637-645. PMID 3904081.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.