JTE-907
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(IUPAC) ime | |||
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N-(benzo[1,3]dioksol-5-ilmetil)-7-metoksi-2-okso-8-pentiloksi-1,2-dihidrohinolin-3-karboksamid | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 282089-49-0 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 9867770 | ||
Hemijski podaci | |||
Formula | C24H26N2O6 | ||
Mol. masa | 438,472 | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
JTE-907 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni inverzni agonist CB2 receptora.[3][4] On ima antiinflamatorno dejstvo u životinjskim studijama.[5] Smatra se da posreduje interakciju između CB2 receptora u IgE.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (2001). „In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor”. The Journal of Pharmacology and Experimental Therapeutics 296 (2): 420–5. PMID 11160626.
- ↑ Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T (2006). „Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists”. Journal of Medical Chemistry 49 (6): 2022–7. DOI:10.1021/jm050879z. PMID 16539390.
- ↑ Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H (2005). „Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice”. European Journal of Pharmacology 520 (1–3): 164–71. DOI:10.1016/j.ejphar.2005.08.013. PMID 16153638.
- ↑ Ueda Y, Miyagawa N, Wakitani K (2007). „Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice”. Life Sciences 80 (5): 414–9. DOI:10.1016/j.lfs.2006.09.026. PMID 17055000.