Milamelin

Milamelin
(IUPAC) ime
	(E)-N-metoksi-1-(1-metil-1,2,5,6-tetrahidropiridin-3-il)metanimin
Klinički podaci
Identifikatori
CAS broj	139886-32-1
ATC kod	nije dodeljen
PubChem	9571002
ChemSpider	7845468
UNII	R9X77R42FN
Hemijski podaci
Formula	C8H14N2O
Mol. masa	154,21 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+ ; Key: YMMXHEYLRHNXAB-RMKNXTFCSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Milamelin (CI-979, PD-129,409, RU-35,926) je neselektivni parcijalni agonist muskarinski acetilholinski receptor koji utiče na spoznaju. Milamelin je ispitivan za moguću primenu u lečenju Alchajmerove bolesti. Rezultati kliničkih ispitivanja su bili loši, te je dalji razvoj prekinut.^[4]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Sedman AJ, Bockbrader H, Schwarz RD (1995). „Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease”. Life Sciences 56 (11-12): 877–82. DOI:10.1016/0024-3205(95)00023-Y. PMID 10188788.

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