Introduction: Elderly patients have higher rates of morbidity and mortality during hospitalizations, diagnostic and surgical procedures. In order to improve the quality of care for the elderly, the APOIO (Preoperative Assessment of Elderly and Care Guidance) protocol was created, a tool to measure the risks of surgical complications. Objective: To evaluate the impact of APOIO on several outcomes, in order to validate it as a useful vehicle in the prevention of perioperative complications in elderly patients with fractures. Method: Retrospective cross-sectional study through review of 218 medical records of elderly patients hospitalized for fractures, and with surgical indication, having collected data on sex, age, reason for hospitalization, type of fracture, indication or not of surgical treatment, evaluation or not by APOIO, indication or not of ICU in the postoperative period, length of ICU stay, total length of hospitalization, immediate outcome and outcome within 30 days after the operation. Result: It was found that the application of APOIO was associated with a 70% reduction in the chances of death during hospitalization (p=0.040), length of stay in the ICU (p<0.001) and total length of hospital stay (p = 0.010). There was also a trend towards a reduction in the death rate within 30 days of the postoperative period (p = 0.117). Conclusion: The application of the APOIO tool reduces the length of hospitalization, optimizes indication and length of stay in the ICU and, also, reduces the risk of death in elderly people undergoing surgical treatment for fractures.

Introdução: Pacientes idosos apresentam maior morbidade e mortalidade em internamentos hospitalares, procedimentos diagnósticos e cirúrgicos. Buscando melhorar a qualidade assistencial aos idosos foi criado o protocolo APOIO (Avaliação Pré-Operatória de Idosos e Orientação de cuidados), ferramenta para mensurar os riscos de complicações cirúrgicas. Objetivo: Avaliar o impacto do APOIO sobre vários desfechos, a fim de validá-lo como veículo útil na prevenção de complicações perioperatórias em idosos com fraturas. Método: Pesquisa retrospectiva transversal por meio de revisão de 218 prontuários de pacientes idosos internados por fraturas, e com indicação cirúrgica, tendo sido coletados dados sobre sexo, idade, motivo do internamento, tipo de fratura, indicação ou não de tratamento cirúrgico, avaliação ou não pela APOIO, indicação ou não de UTI no pós-operatório, duração do internamento em UTI, duração total do internamento, desfecho imediato e desfecho em 30 dias após a operação. Resultado: Foi constatado que a aplicação do APOIO foi associada à redução de 70% nas chances de óbito durante o internamento (p = 0,040), ao tempo de permanência em UTI (p <0,001) e ao tempo total de internamento hospitalar (p =  0,010). Observou-se ainda tendência à redução na taxa de óbitos em 30 dias do pós-operatório (p = 0,117). Conclusão: A aplicação da ferramenta APOIO reduz tempo de internamento, otimiza indicação e tempo de permanência em UTI e ainda diminui o risco de óbito de idosos submetidos a tratamentos cirúrgicos de fraturas.

Introdução : A obesidade tem sido associada ao aparecimento ou piora de doenças autoimunes. Objetivo : Revisar a presença de autoanticorpos em obesos submetidos à cirurgia bariátrica e verificar a possível alteração deste perfil após o procedimento cirúrgico. Método : Revisão narrativa da literatura efetuada no PubMed e Scielo. A busca utilizou as palavras-chave: “ obesidade, autoimunidade, fator antinuclear, cirurgia bariátrica” . Os critérios de inclusão compreenderam artigos de revisão, estudos experimentais, pesquisas pré-clínicas e clínicas, escritos em português e inglês e disponíveis em texto completo. Resultado : Foram incluídos 63 artigos. Conclusão : Existe alta prevalência de FAN positiva na população obesa e candidata à cirurgia bariátrica que diminui consideravelmente no pós-operatório. O mesmo não pode ser verificado com o fator reumatóide, anticorpos do perfil ENA e anti-ds DNA, anticorpos anticardiolipina IgG e IgM, e anticorpos anti-endomísio. Nenhuma variável clínica ou antropométrica pôde estar ligada à presença de autoanticorpos, salvo níveis de vitamina D que foram significativamente menores nos indivíduos no pré-operatório e FAN positivos.

Introdução : A obesidade tem sido associada ao aparecimento ou agravamento de doenças autoimunes. Objetivo : Rever a presença de autoanticorpos em pacientes obesos submetidos à cirurgia bariátrica e verificar a possível alteração deste perfil após o procedimento cirúrgico. Método : Revisão narrativa da literatura realizada no PubMed e Scielo. A busca utilizou as palavras-chave: “ obesidade, autoimunidade, fator antinuclear, cirurgia bariátrica ”. Os critérios de inclusão compreenderam artigos de revisão, estudos experimentais, pesquisas pré-clínicas e clínicas, escritos em português e inglês e disponíveis em texto completo. Resultado : foram incluídos 63 artigos. Conclusão : Existe alta prevalência de FAN positivo na população obesa e candidata à cirurgia bariátrica, que diminui consideravelmente no pós-operatório. O mesmo não pode ser verificado com fator reumatoide, anticorpos ENA e anti-ds DNA, anticorpos IgG e IgM anticardiolipina e anticorpos antiendomísio. Nenhuma variável clínica ou antropométrica pôde ser associada à presença de autoanticorpos, exceto os níveis de vitamina D, que foram significativamente mais baixos nos indivíduos pré-operatórios e ANA-positivos.

Introduction: Non-melanoma skin neoplasms (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) form the most common group of all types of neoplasms. Although cancer is not yet being classified as a channelopathy, it has been suggested that pumps and ionic channels contribute to its progression by affecting autophagy, which could become an important therapeutic target in this context. Objective: To evaluate the immunohistochemical expression of IP3R in both skin tumors. Method: Immunohistochemistry was performed on 60 slides of non-melanoma cancer using primary anti-IP3R antibodies, verifying their presence and quantifying Results: For the first time, IP3R immunolocalization was identified in non-melanoma skin neoplasms, being evident above 90% of neoplastic cells was observed in all slides studied, regardless of the histological pattern, invasion and other tumor characteristics. Unlike what was seen in the internal control of normal skin, in which there was immunolocalization of IP3R in basal cell, in tumors, immunohistochemical expression occurred throughout the entire body of the neoplasm. Conclusion: There was immunolocalization of IP3R in tumor cells in both BCC and SCC. It was not possible to establish a correlation between tumor characteristics and IP3R expression, as immunostaining was similar in all analyzed samples. Despite this, IP3R to be associated with the pathophysiology of non-melanoma skin cancer, but its expression does not seem to be associated with tumor aggressiveness.

Introdução: As neoplasias de pele não melanoma (carcinoma basocelular (CBC) e carcinoma espinocelular (CEC) formam o grupo mais comum de todos os tipos de neoplasias. Embora o câncer ainda não esteja sendo pautado como canalopatia, tem sido sugerido que bombas e canais iônicos contribuem para a sua progressão por afetar a autofagia. Proteínas iônicas, em especial as de canais de cálcio, como o receptor da fosfatidil inositol 3 (IP3R) participam de maneira ativa na autofagia por estarem envolvidas na etapa inicial de formação do autofagossomo, podendo se tornar em alvo terapêutico importante neste contexto. Objetivo: Avaliar a expressão imuno histoquímica do IP3R em ambos os tumores de pele. Método: Foi realizada imuno histoquímica em 60 lâminas de câncer não melanoma utilizando anticorpos primários anti-IP3R verificando a sua expressão. Resultados: Pela primeira vez foi identificada a imunolocalização do IP3R em câncer de pele não melanoma, sendo evidente em mais de 90% das células neoplásicas em todas as lâminas estudadas, independentemente do padrão histológico, invasão e demais características tumorais. Diferentemente do visualizado no controle interno de pele normal, no qual houve imunolocalização de IP3R em células basais, nos tumores, a expressão imuno histoquímica ocorreu em todo o corpo da neoplasia. Conclusão: Houve imunolocalização de IP3R em células tumorais tanto em CBC quanto em CEC. Não foi possível estabelecer correlação entre as características tumorais e a expressão de IP3R, pois a imunomarcação apresentou-se de forma similar em todas as amostras analisadas. Apesar disso, IP3R está associado à fisiopatologia do câncer de pele não melanoma, mas a sua expressão não parece estar associada à agressividade tumoral.

Abstract Objectives: to study the side effects and the risk of disease flare after COVID-19 vaccination in Brazilian patients with Systemic Lupus erythematosus (SLE). Materials and methods: this retrospective study investigated a sample of 101 SLE patients for disease activity through the SLE disease activity index (SLEDAI) prior to and after two vaccine doses against SARS-COv-2. Side effects after vaccination were recorded. Results: in this sample, patients receiving two doses of the same vaccine were 10.3% for CoronaVAc; 42.2% for Pfizer, and 47.3% for Astra-Zeneca. Side effects were detected in 76.2% of them, and most of them were mild and moderate; the most common were local pain (62.3%), headache (36.6%), and fatigue (34.6%). The SLEDAI prior to the first dose and after the second dose did not change significantly (p=0.68). Only 4.1% of individuals had increased in SLEDAI ≥than 3 points. Conclusions: vaccination against COVID-19 was well tolerated and safe in SLE patients.

Resumen Objetivos: estudiar los efectos secundarios y el riesgo de exacerbación de la enfermedad después de la vacunación COVID-19 en una muestra de pacientes con lupus eritematoso sistémico (LES). Materiales y métodos: estudio retrospectivo que investigó 101 pacientes con LES. Se determinó la actividad de la enfermedad mediante el Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) antes y después de dos dosis de la vacuna contra el SARS-COv-2. Se registraron los efectos secundarios después de la vacunación. Resultados: los pacientes que recibieron dos dosis de la misma vacuna fueron el 10,3% para CoronaVAc, el 42,2% para Pfizer y el 47,3% para AstraZeneca. Se detectaron efectos secundarios en el 76,2% y la mayoría fue leve/moderado. Los más frecuentes fueron: dolor local (62,3%), cefalea (36,6%) y fatiga (34,6%). El cambio en la mediana del SLEDAI antes de la primera dosis y después de la segunda no fue estadísticamente significativo (p=0,68). Solo el 4,1% de los individuos aumentó el SLEDAI ≥ de 3 puntos. Conclusiones: la vacunación contra la COVID-19 fue bien tolerada y segura en pacientes con LES.

SUMMARY BACKGROUND: Routine screening for viral infections at blood donation is important to avoid transfusion-transmitted infections. It also offers an opportunity to detect an asymptomatic infection. OBJECTIVE: To study changes in serology positivity for viral infections (B and C hepatitis, HTLV-1/2, and HIV) at blood donation in a blood bank from Southern Brazil, comparing two periods of 5 years: the period from 2013 to 2017 with the period from 2018 to 2022. In addition, data on the donor fidelity rate during the studied period were sought. METHODS: Retrospective study using data from 2013 to 2022 from a single blood center electronic database from Curitiba, Southern Brazil. RESULTS: A significant drop in positive serology for all studied viruses was observed: highest in HIV (OR=0.39; 95% CI=0.27–0.57) and lowest in total anti HBc (0.56; 95 CI=0.50–0.63). Anti HBc serology became more commonly seen in women in the period of 2018–2022 when compared to men. No changes in the distribution of positive serology according to donors’ ages were observed. Loyalty rates had a median of 70%, with the lowest being 60% in 2013, while the highest was 73% in 2018 and 2022. CONCLUSION: A significant reduction in discarded blood bags due to viral serology was observed when the period of 2013–2017 was compared to 2018–2022 on this blood bank; the highest reduction was observed in HIV serology and the lowest in HBc serology, which became more common in women in the second period. High rates of donor fidelity were observed during the period studied. BACKGROUND transfusiontransmitted transfusion transmitted infection OBJECTIVE B hepatitis HTLV1/2, HTLV12 HTLV 1/2, 1 2 HTLV-1/2 Brazil years 201 addition sought METHODS 202 Curitiba RESULTS OR=0.39 OR039 OR 0 39 (OR=0.39 CI=0.27–0.57 CI027057 CI 27 57 0.56 056 56 (0.56 9 CI=0.50–0.63. CI050063 CI=0.50–0.63 . 50 63 CI=0.50–0.63) 20182022 2018–202 men donors 70 70% 60 73 CONCLUSION 20132017 2013–201 HTLV1 HTLV1/2 12 1/2 HTLV-1/ 20 OR=0.3 OR03 3 (OR=0.3 CI=0.27–0.5 CI02705 0.5 05 (0.5 CI05006 CI=0.50–0.6 6 2018202 2018–20 7 2013201 2013–20 HTLV1/ 1/ HTLV-1 OR=0. OR0 (OR=0. CI=0.27–0. CI0270 0. (0. CI0500 CI=0.50–0. 201820 2018–2 201320 2013–2 HTLV- OR=0 (OR=0 CI=0.27–0 CI027 (0 CI050 CI=0.50–0 20182 2018– 20132 2013– OR= (OR= CI=0.27– CI02 ( CI05 CI=0.50– (OR CI=0.27 CI0 CI=0.50 CI=0.2 CI=0.5 CI=0. CI=0 CI=

Abstract Background Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy. Methods A cross-sectional study including consecutive patients with PsO and PsA was carried out. The study patients were divided into 4 groups, totaling 120 participants. Group 1: patients with psoriasis vulgaris and clinically normal nails; Group 2: patients with psoriasis vulgaris and onychodystrophy; Group 3: patients with psoriatic arthritis and clinically normal nails; Group 4: patients with psoriatic arthritis and onychodystrophy; All patients were submitted to dermatological and rheumatological clinical analysis. Ultrasound examinations was performed by a single examiner, blinded to all clinical data, with ultrasound high resolution, in B-mode or gray-scale (GS), Power Doppler (PD) and Spectral Doppler. Results A significant difference was found between the groups regarding the variable Psoriasis Area and Severity Index (PASI) (p = 0.008) and body surface area (BSA) (p = 0.005), with patients with psoriatic arthritis having lower PASI and BSA compared to patients with only cutaneous psoriasis. A positive relationship was found with the average ultrasound thickness of the nail bed and the Nail Psoriasis Severity Index (NAPSI) in correlation analysis (rho = 0.344). When we grouped patients with psoriasis and psoriatic arthritis, there was no significant difference between the cutaneous psoriasis groups and the psoriatic arthritis groups in terms of nail plate GS (p = 0.442), nail bed PD (p = 0.124). Conclusion Greater nail bed thickness indicates early psoriatic nail disease, as confirmed in our study correlating NAPSI with nail bed thickness. Ultrasonography is a low-cost exam, promising in the evaluation, showing that the ultrasound grayscale is consistent with those who have dystrophic nails, but it can't distinguish psoriasis from psoriatic arthritis, even in those with nail dystrophy. Pso (Pso (PsA enthesis dystrophy crosssectional cross sectional out 12 participants 1 2 onychodystrophy 3 examiner data resolution Bmode B mode gray scale GS, , (GS) (PD (PASI p 0.008 0008 0 008 (BSA 0.005, 0005 0.005 005 0.005) (NAPSI rho 0.344. 0344 0.344 . 344 0.344) 0.442, 0442 0.442 442 0.442) 0.124. 0124 0.124 124 0.124) disease lowcost low cost exam evaluation cant can t (GS 0.00 000 00 034 0.34 34 044 0.44 44 012 0.12 0.0 03 0.3 04 0.4 01 0.1 0.

SUMMARY OBJECTIVE: The aim of the study was to compare the epidemiology and clinical profiles of hospital admissions in a single Brazilian Hepatology Unit from the period 2014–2017 to 2019–2022. METHODS: A retrospective analysis of hospital database from the abovementioned periods was done. The study included patients over the age of 18 years who were hospitalized due to complications of diseases such as viral hepatitis, alcoholic disease, nonalcoholic fatty liver disease, and autoimmune liver and drug-induced hepatitis. RESULTS: In both study periods, middle-aged males were predominant and were younger than females. In the first period (2014–2017), hepatitis C (33.5%) was the most prevalent cause of admission, followed by alcoholic liver disease (31.7%). In the second period (2019–2022), nonalcoholic fatty liver disease (38%) and alcoholic liver disease (27.6%) were the most frequent causes of admission. No changes were observed in the proportion of alcoholic liver disease or drug-induced hepatitis in both study periods. The prevalence of viral hepatitis decreased in both genders, with hepatitis C decreasing from 32.4 to 9.7% for males and 35.4 to 10.8% for females, and OR=0.2; 95%CI 0.1–0.3 for both males and females. Similarly, the prevalence of hepatitis B decreased from 19.1 to 8.1% and OR=0.3; 95%CI 0.2–0.5 for males and 8.2 to 3.7% and OR=0.4; 95%CI 0.1–0.9 for females. The prevalence of autoimmune liver diseases increased only in males, from 2.1 to 5.9% and OR=2.9; 95%CI 1.2–6.6. CONCLUSION: Over the past 4 years, there has been a shift in hospital admission profile at a Brazilian Hepatology Unit, with a decrease in viral hepatitis and an increase in autoimmune diseases and nonalcoholic fatty liver disease. Males were more affected at younger ages than females. Furthermore, ascites was the most prevalent cause of complications in both periods analyzed. OBJECTIVE 20142017 2014 2017 2014–201 20192022 2019 2022 2019–2022 METHODS done 1 druginduced drug induced RESULTS middleaged middle aged females 2014–2017, , (2014–2017) 33.5% 335 33 5 (33.5% 31.7%. 317 31.7% . 31 7 (31.7%) 2019–2022, (2019–2022) 38% 38 (38% 27.6% 276 27 6 (27.6% genders 324 32 32. 97 9 9.7 354 35 35. 108 10 8 10.8 OR=0.2 OR02 OR 0 2 95CI CI 95 0103 3 0.1–0. Similarly 191 19 19. 81 8.1 OR=0.3 OR03 0205 0.2–0. 82 8. 37 3.7 OR=0.4 OR04 0109 21 2. 59 5.9 OR=2.9 OR29 1266 1.2–6.6 CONCLUSION Furthermore analyzed 2014201 201 2014–20 2019202 202 2019–202 (2014–2017 33.5 (33.5 31.7 (31.7% (2019–2022 (38 27.6 (27.6 9. 10. OR=0. OR0 010 0.1–0 020 0.2–0 3. 5. OR=2. OR2 126 1.2–6. 201420 20 2014–2 201920 2019–20 (2014–201 33. (33. 31. (31.7 (2019–202 (3 27. (27. OR=0 01 0.1– 02 0.2– OR=2 12 1.2–6 20142 2014– 20192 2019–2 (2014–20 (33 (31. (2019–20 ( (27 OR= 0.1 0.2 1.2– 2019– (2014–2 (31 (2019–2 (2 0. 1.2 (2014– (2019– 1. (2014 (2019 (201 (20

RESUMO Contexto: A baixa densidade de massa óssea (DMO) é um achado extraintestinal na doença celíaca (DC). Isso pode resultar em fraturas ósseas levando à perda de qualidade de vida. Objetivo: Avaliar a DMO em pacientes masculinos com DC no momento do diagnóstico de acordo com a idade do paciente. Métodos: Estudo retrospectivo descritivo realizado no período entre 2013 e 2023 em um único consultório que estudou resultados de “dual-energy X-ray absorptiometry” (DEXA) em 28 pacientes do sexo masculino com diagnóstico recente de DC, divididos em três grupos: grupo 1 (idade até 18 anos); grupo 2 (de 19 a 49 anos) e grupo 3 (acima de 50 anos). Foram estudados parâmetros demográficos e antropométricos, tempo decorrido entre o início dos sintomas e o diagnóstico da DC e ocorrência de fraturas. Resultados: Os pacientes celíacos estudados tinham mediana de idade de 36,0 anos (IIQ=16,5-50,7). Dentre eles, 39,3% apresentavam osteopenia e 14,3% apresentavam osteoporose. Apenas 36% da amostra apresentou valores normais de DEXA (grupo 1 com 37,5%; grupo 2 com 46% e grupo 3 com 14,2%). Nenhuma fratura patológica foi observada nesta amostra. O atraso no diagnóstico da DC observado teve mediana de 1,0 ano (IQR=1,0-4,7). Quando comparado o número de indivíduos com resultados de DEXA normais e alterados, não houve diferença no índice de massa corporal, tempo de atraso no diagnóstico ou classificação de Marsh (P=0,18). Conclusão: Pacientes do sexo masculino no momento do diagnóstico da DC apresentaram alta prevalência de baixa DMO, o que foi particularmente evidente em indivíduos com mais de 50 anos de idade. Contexto (DMO DC. . (DC) vida Objetivo paciente Métodos 201 202 dualenergy dual energy Xray X ray absorptiometry (DEXA grupos 4 acima 5 anos. antropométricos Resultados 360 36 0 36, IIQ=16,550,7. IIQ165507 IIQ IIQ=16,5 50,7 16 7 (IIQ=16,5-50,7) eles 393 39 39,3 143 14 14,3 osteoporose 37,5% 375 37 46 14,2%. 142 14,2% 14,2%) 10 1, IQR=1,04,7. IQR1047 IQR IQR=1,0 4,7 (IQR=1,0-4,7) alterados corporal P=0,18. P018 P P=0,18 (P=0,18) Conclusão (DC 20 550 IIQ=16,550,7 IIQ16550 IIQ165 IIQ=16, 507 50, (IIQ=16,5-50,7 39, 14, 37,5 14,2 04 IQR=1,04,7 IQR104 IQR10 IQR=1, 47 4, (IQR=1,0-4,7 P01 P=0,1 (P=0,18 55 IIQ=16,550, IIQ1655 IIQ16 IIQ=16 (IIQ=16,5-50, 37, IQR=1,04, IQR1 IQR=1 (IQR=1,0-4, P0 P=0, (P=0,1 IIQ=16,550 IIQ1 IIQ=1 (IIQ=16,5-50 IQR=1,04 IQR= (IQR=1,0-4 P=0 (P=0, IIQ=16,55 IIQ= (IIQ=16,5-5 (IQR=1,0- P= (P=0 (IIQ=16,5- (IQR=1,0 (P= (IIQ=16,5 (IQR=1, (P (IIQ=16, (IQR=1 (IIQ=16 (IQR= (IIQ=1 (IQR (IIQ= (IIQ

ABSTRACT Background: Low bone mass density (BMD) is an extraintestinal finding in celiac disease (CD). This may result in bone fractures leading to loss in quality of life. Objective: To assess BMD in male CD patients at diagnosis according to the patient’s age. Methods: Descriptive retrospective carried out during the period between 2013 and 2023 in a single office that studied dual-energy X-ray absorptiometry (DXA) results in 28 male patients with a recent diagnosis of CD, divided into three groups: group 1 (age up to 18 years); group 2 (from 19 to 49 years of age) and group 3 (over 50 years of age). Were studied demographic and anthropometric parameters, time delay between symptoms onset and CD diagnosis and fracture occurrence. Results: Celiac patients studied had median age 36.0 years (IQR=16.5-50.7). Among them, 39.3% had osteopenia and 14.3% had osteoporosis. Only 36% of the sample had normal DXA values (group 1 with 37.5%; group 2 with 46% and group 3 with 14.2%). No pathological fracture was observed in this sample. CD diagnosis delay observed had median 1.0 year (IQR=1.0-4.7). When the number of individuals with normal and abnormal DXA results were compared, there was no difference in body mass index, time of diagnosis delay or Marsh classification (P=0.18). Conclusion: Male patients at the time of CD diagnosis showed a high prevalence of low BMD, which was particularly evident in individuals over 50 years of age. Background (BMD CD. . (CD) life Objective patient s Methods 201 202 dualenergy dual energy Xray X ray (DXA groups years) from 4 5 parameters occurrence Results 360 36 0 36. IQR=16.550.7. IQR165507 IQR IQR=16.5 50.7 16 7 (IQR=16.5-50.7) them 393 39 39.3 143 14 14.3 osteoporosis 37.5% 375 37 46 14.2%. 142 14.2% 14.2%) 10 1. IQR=1.04.7. IQR1047 IQR=1.0 4.7 (IQR=1.0-4.7) compared index P=0.18. P018 P P=0.18 (P=0.18) Conclusion (CD 20 550 IQR=16.550.7 IQR16550 IQR165 IQR=16. 507 50. (IQR=16.5-50.7 39. 14. 37.5 14.2 04 IQR=1.04.7 IQR104 IQR10 IQR=1. 47 4. (IQR=1.0-4.7 P01 P=0.1 (P=0.18 55 IQR=16.550. IQR1655 IQR16 IQR=16 (IQR=16.5-50. 37. IQR=1.04. IQR1 IQR=1 (IQR=1.0-4. P0 P=0. (P=0.1 IQR=16.550 (IQR=16.5-50 IQR=1.04 IQR= (IQR=1.0-4 P=0 (P=0. IQR=16.55 (IQR=16.5-5 (IQR=1.0- P= (P=0 (IQR=16.5- (IQR=1.0 (P= (IQR=16.5 (IQR=1. (P (IQR=16. (IQR=1 (IQR=16 (IQR= (IQR

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. HLAB27 HLAB HLA B27 B HLA-B2 SpA, , (SpA) worldwide However mixedrace mixed race populations RBE. . (RBE) multicenter observational 4 Brazil follow 1 (1 rheumatologist 2 (2 18 ≥1 years 3 (3 axial protocol historical 109 included 734 73 73.4 444 44 44. ±13.2 132 13 (±13.2 uveitis Conversely psoriasis activity mobility world Furthermore HLAB2 B2 HLA-B (SpA (RBE ( ≥ 10 7 73. ±13. (±13. ±13 (±13 ±1 (±1 ± (±

SUMMARY BACKGROUND: Inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis are influenced by environmental and immunological factors and may differ according to the patient’s sex. OBJECTIVE: The objective was to study the differences in the clinical profile of a Brazilian sample of inflammatory bowel disease patients according to sex. METHODS: Retrospective study with chart review of 158 inflammatory bowel disease patients (43 with Crohn’s disease and 115 with ulcerative colitis) from a single university hospital in southern Brazil. RESULTS: The Crohn’s disease sample showed a female/male ratio of 2.1, and the sample of ulcerative colitis showed a ratio of 1.5. The only significant difference found in the clinical profile was an increased constipation rate in female patients with ulcerative colitis. No other differences in epidemiological, symptom profile, or treatment could be detected. CONCLUSIONS: More females with inflammatory bowel diseases sought healthcare facilities compared to males. The only notable difference was a higher incidence of constipation symptoms among females; all other aspects were similar between the sexes. BACKGROUND Crohns Crohn s patient sex OBJECTIVE METHODS 15 43 (4 11 Brazil RESULTS femalemale male 21 2 1 2.1 5 1.5 epidemiological detected CONCLUSIONS males sexes 4 ( 2. 1.

Introduction: The Charlson comorbidities index (CCI) assesses a person's chances of survival over the next 10 years. In systemic lupus erythematosus (SLE), multiple comorbidities and complications affect patient survival. Objetive: Analize the variables that influence the CCI of a group of females with SLE. Methods: Retrospective study of medical records of 100 lupus patients for CCI, clinical, epidemiological and serological variables. Results: No epidemiological variable interfered in CCI. Regarding clinical manifestations, patients with glomerulonephritis had a worse CCI than those without (p<0.0001) and those with central nervous system manifestations had a tendency to worse CCI (p=0.09). Patients with anti-Ro antibodies (p=0.02) and rheumatoid factor or RF (p=0.002) were associated with a lower CCI. Conclusions: The presence of glomerulonephritis is associated with lower survival and of the anti-Ro and RF antibodies with longer survival in SLE.

Introdução : O índice de comorbidades de Charlson (ICC) avalia as chances de sobrevivência de uma pessoa nos próximos 10 anos. No lúpus eritematoso sistêmico (LES) múltiplas comorbidades e complicações afetam a sobrevida. Objetivo : Verificar as variáveis ​​que influenciam no ICC de um grupo de mulheres com LES. Métodos : Estudo retrospectivo de 100 pacientes lúpicas para o ICC, variáveis ​​clínicas, epidemiológicas e sorológicas. Resultados : Nenhuma variável epidemiológica interferiu no ICC. Quanto à clínica, pacientes com glomerulonefrite tiveram pior ICC do que os sem (p<0,0001) e os com manifestações de sistema nervoso central tiveram tendência para pior ICC (p=0,09). Portadores de anticorpos anti-Ro (p=0,02) e fator reumatoide (FR; p=0,002) se associaram com ICC menor. Conclusões : A presença de glomerulonefrite se associa com menor sobrevida, e a dos anticorpos anti-Ro e FR com maior sobrevida no LES.

RESUMO Objetivo: Este estudo avaliou os níveis de calprotectina fecal em uma série de pacientes com uveíte anterior na tentativa de determinar se pacientes com uveíte associada com espondiloartrites apresentam níveis mais elevados desta proteína do que pacientes com uveíte anterior de outras etiologias. Um terceiro grupo com espondiloartrites sem uveíte também foi incluído na avaliação para entendimento do papel da uveíte anterior no aumento da calprotectina fecal. Métodos: Estudo transversal de 28 pacientes divididos em três grupos: (a) com espondiloartrites e uveíte (n=9); (b) com espondiloartrites sem uveíte (n=10) e (c) com uveíte sem espondiloartrites (n=9). A dosagem de calprotectina fecal foi avaliada. Resultados: Pacientes com uveíte anterior associada a espondiloartrites apresentaram valores medianos maiores de calprotectina fecal (101 µg/g) que os valores dos pacientes com uveíte sem espondiloartrites (9 µg/g), pacientes com espondiloartrites sem uveíte que também demonstraram valores maiores (93.0 µg/g) que os dos pacientes com uveíte sem espondiloartrites (p=0,02). Conclusão: Pacientes com espondiloartrites com e sem uveíte anterior aguda demonstraram níveis significativamente elevados de calprotectina fecal. Este teste pode ser útil na diferenciação entre uveítes associadas com espondiloartrites de uveítes de outras etiologias. Entretanto, não foi possível demonstrar associação entre o aumento dos níveis de calprotectina fecal e a presença da uveíte em espondiloartrites. Objetivo etiologias Métodos 2 grupos (a n=9 n9 n 9 (n=9) b (b n=10 n10 10 (n=10 c (c n=9. . avaliada Resultados 101 (10 µg/g µgg µg g ( µg/g, , 93.0 930 93 0 (93. p=0,02. p002 p p=0,02 02 (p=0,02) Conclusão Entretanto n= (n=9 n=1 n1 1 (n=1 (1 93. (93 p00 p=0,0 (p=0,02 (n= p0 p=0, (p=0,0 (n p=0 (p=0, p= (p=0 (p= (p

ABSTRACT Purpose: This study measured fecal calprotectin levels in a series of patients with anterior uveitis in order to determine whether anterior uveitis patients with associated spondyloarthritis have higher levels of fecal calprotectin than patients with anterior uveitis of other etiologies. A third group of patients with spondyloarthritis without uveitis was also evaluated to understand the role of acute anterior uveitis in increasing fecal calprotectin. Methods: In this cross-sectional study, 28 patients were divided into three groups: (a) Group 1, spondyloarthritis and uveitis (n=9); (b) Group 2, spondyloarthritis without uveitis (n=10); and (c) Group 3, uveitis without spondyloarthritis (n=9). The levels of fecal calprotectin were determined. Results: Groups 1 and 2 showed higher median fecal calprotectin levels (101.0 and 93.0 µg/g, respectively) compared with Group 3 (9.0 µg/g) (p=0.02). However, no relationship between fecal calprotectin levels and the presence of uveitis with spondyloarthritis could be demonstrated. Conclusion: Patients with spondyloarthritis with or without acute anterior uveitis have significantly elevated levels of fecal calprotectin. This test may be useful for differentiating spondyloarthrit-associated uveitis from uveitis of other etiologies. Purpose etiologies Methods crosssectional cross sectional groups (a n=9 n9 n 9 (n=9) b (b n=10 n10 10 (n=10) c (c n=9. . determined Results 101.0 1010 101 0 (101. 930 93 93. µgg µg g µg/g respectively 9.0 90 (9. p=0.02. p002 p p=0.02 02 (p=0.02) However demonstrated Conclusion spondyloarthritassociated spondyloarthrit n= (n=9 n=1 n1 (n=10 101. (101 9. (9 p00 p=0.0 (p=0.02 (n= (n=1 (10 ( p0 p=0. (p=0.0 (n (1 p=0 (p=0. p= (p=0 (p= (p

Abstract Background Psoriasis is a protean disease associated with several comorbidities that may have increased levels of adiponectin such as resistin. This may affect the patients atherosclerotic risk. Objective To study resistin levels in a sample of Brazilian patients with psoriasis and its association with clinical profile, comorbidities, and carotid Intima-Media Thickness (cIMT). Methods This is a cross-sectional study of 119 individuals: 34 healthy controls and 85 patients with psoriasis, 42 of which with skin involvement only and 43 with psoriatic arthritis. Clinical and epidemiological data, measurement of PASI (Psoriasis Area Severity Index) and DAPSA (Disease Activity in Psoriatic Arthritis), lipid profile, cIMT by ultrasound were collected from medical records. Resistin serum levels were measured by ELISA. Results Patients with psoriasis had higher resistin levels (p = 0.009) and worse cIMT (p = 0.0002) than controls. In the psoriasis sample, no associations of resistin levels with epidemiological, clinical findings, and activity indexes were found. Resistin serum levels were associated with the presence of diabetes (p = 0.008) and metabolic syndrome (p = 0.01) and correlated with total cholesterol (r = 0.26) and triglycerides (r = 0.33) but not with cIMT. Study limitations This work is limited by its transversal design and by the limited number of patients included. Conclusion Resistin serum levels are elevated in psoriasis patients. In this sample, clinical, epidemiological, and activity indexes were not linked to resistin serum levels, but atherosclerotic risk factors were. profile IntimaMedia Intima Media . (cIMT) crosssectional cross sectional 11 individuals 3 8 4 arthritis data Index Disease Arthritis, Arthritis , Arthritis) records ELISA p 0.009 0009 0 009 0.0002 00002 0002 findings found 0.008 0008 008 0.01 001 01 r 0.26 026 26 0.33 033 33 included (cIMT 1 0.00 000 00 0.000 0000 0.0 0.2 02 2 0.3 03 0.

Aim To investigate the presence of periodontitis in RA patients comparing it with controls in a Brazilian sample. Methods This is a case control study conducted in a public health rheumatologic center. One hundred and sixteen RA patients and 68 paired controls were compared for epidemiological data and presence of periodontal disease evaluated by number of remaining teeth, presence of bacterial plaque, bleeding on probing, probing depth and clinical level of gingival insertion. In addition, data on comorbidities was collected. Results RA patients and controls have the same amount of teeth loss (P = 0.84). RA patients had more calculus (P = 0.02); dental plaques (P = 0.04); gingival recession (P = 0.02) and bleeding (P = 0.01). Although the number of individuals with periodontitis was higher in RA patients, the severity of periodontitis was similar in both groups (P = ns). Presence of diabetes and hypothyroidism also associated with periodontitis (P = 0.01 and 0.02 respectively). In a model of logistic regression built to assess the independence of association of RA and its comorbidities with periodontitis, only diabetes and RA remained independent. Conclusion This case control study shows higher frequency of periodontitis in RA patients than controls. sample center 6 plaque insertion addition collected P 0.84. 084 0.84 . 0 84 0.84) 002 02 0.04 004 04 0.04) 0.01. 001 01 0.01) ns. ns ns) 0.0 respectively. respectively respectively) independent 08 0.8 8 00 0.

Introdução: A alopecia frontal fibrosante (AFF) é uma cicatriz linfocítica, com queda de cabelo pela linha de implantação frontal do couro cabeludo e outras áreas do corpo. Drogas tópicas e sistêmicas, como casos o MTX, não controlam a atividade da doença na maioria dos casos, a necessidade de novas terapias. Objetivo: Avaliar a diligência da microinfusão de metotrexato em AFF. Métodos: Ensaio clínico prospectivo, controlador, realizado com 17 voluntários com 1 diagnóstico clínico e histológico de AFF. As aplicações de MTX por MMP® (método de microinfusão de pele) foram feitas a cada 30 dias, num total de 3 aplicações, na direita da área de alopecia; a outra metade serviu como controle.medidas frontais glalares e parciais, dermatoscópicas, índice de avaliação externa dos olhos, a percepção do plano dos sinais do paciente (LPPAI). Hemograma total e testes de função hepática também foram médios. Resultados: Houve uma redução significativa nas medidas fronto-glabela e frontal temporo-parietal no local tratado, enquanto no local nãou a AAF aumentou. A paciente refere melhora do prurido e descamação, mas não da queda de cabelo e eritema local. A das fotos dermatoscópicas e a análise do LPPAI não são relevantes. Cerca de 9 participantes e todos nós não resultaram em 5% dos resultados com nenhum resultado de nenhum dos exames.Conclusão: A aplicação de MTX por MMP® melhorou os sintomas associados à AFF e as medidas fronto-glabela e fronto-parietal.

Introdução: A alopecia frontal fibrosante (AFF) é cicatricial linfocítica, com queda de cabelo pela linha de implantação frontal do couro cabeludo e outras áreas do corpo. Drogas tópicas e sistêmicas, como o metotrexato (MTX), não controlam a atividade da doença na maioria dos casos, mostrando a necessidade de novas terapias. Objetivo: Avaliar a eficácia da microinfusão de metotrexato em AFF. Métodos: Ensaio clínico prospectivo, controlado, realizado com 17 voluntários com diagnóstico clínico e histológico de AFF. As aplicações de MTX por MMP® (método de microinfusão de drogas na pele) foram feitas a cada 30 dias, totalizando 3 aplicações, na metade direita da área da alopecia; a outra metade serviu como controle. Foram avaliadas as medidas frontoglabela e frontal temporoparietal. Fotos de dermatoscopia foram analisadas por avaliadores cegos e externos com percepção de sinais e sintomas do paciente e o Índice de Atividade do Líquen Planopilar (LPPAI). Hemograma total e testes de função hepática também foram medidos. Resultados: Houve redução significativa nas medidas frontoglabela e frontal temporoparietal no local tratado, enquanto no não tratado a AAF aumentou. Houve melhora do prurido e descamação, mas não da queda de cabelo e eritema local. A análise das fotos dermatoscópicas e o cálculo do LPPAI não mostraram alterações relevantes. Cerca de 95% dos participantes ficaram satisfeitos ou muito satisfeitos com os resultados e nenhum deles teve alteração nos resultados dos exames laboratoriais. Conclusão: A aplicação de MTX por MMP® melhorou os sintomas associados à AFF e as medidas frontoglabela e frontoparietal. Esta técnica mostrou-se segura e bem tolerada.