We present an algorithm to perform trust-region-based optimization for nonlinear unconstrained problems. The method selectively uses function and gradient evaluations at different floating-point precisions to reduce the overall energy consumption, storage, and communication costs; these capabilities are increasingly important in the era of exascale computing. In particular, we are motivated by a desire to improve computational efficiency for massive climate models. We employ our method on two examples: the CUTEst test set and a large-scale data assimilation problem to recover wind fields from radar returns. Although this paper is primarily a proof of concept, we show that if implemented on appropriate hardware, the use of mixed-precision can significantly reduce the computational load compared with fixed-precision solvers.