Mathematical tools developed in the context of Shannon information theory were used to
analyze the meaning of the BLOSUM score, which was split into three components termed
as the BLOSUM spectrum (or BLO Spectrum). These relate respectively to the sequence
convergence (the stochastic similarity of the two protein sequences), to the background
frequency divergence (typicality of the amino acid probability distribution in each sequence),
and to the target frequency divergence (compliance of the amino acid variations between …