Existing semi-supervised learning (SSL) methods assume that labeled and unlabeled data share the same class space. However, in real-world applications, unlabeled data always contain classes not present in the labeled set, which may cause classification performance degradation of known classes. Therefore, open-world SSL approaches are researched to handle the presence of multiple unknown classes in the unlabeled data, which aims to accurately classify known classes while fine-grained distinguishing different unknown classes. To address this challenge, in this paper, we propose an open-world SSL method for Self-learning Open-world Classes (SSOC), which can explicitly self-learn multiple unknown classes. Specifically, SSOC first defines class center tokens for both known and unknown classes and autonomously learns token representations according to all samples with the cross-attention mechanism. To effectively discover novel classes, SSOC further designs a pairwise similarity loss in addition to the entropy loss, which can wisely exploit the information available in unlabeled data from instances’ predictions and relationships. Extensive experiments demonstrate that SSOC outperforms the state-of-the-art baselines on multiple popular classification benchmarks. Specifically, on the ImageNet-100 dataset with a novel ratio of , SSOC achieves a remarkable improvement.