The cytoarchitecture of human islets has been examined, focusing on cellular associations
that provide the anatomical framework for paracrine interactions. By using confocal …

Mitochondrial dysfunction is an important contributor to human pathology 1, 2, 3, 4 and it is
estimated that mutations of mitochondrial DNA (mtDNA) cause approximately 0.5–1% of all …

Advanced imaging techniques have become a valuable tool in the study of complex biological
processes at the cellular level in biomedical research. Here, we introduce a new technical …

THE endocrine part of the pancreas plays a central role in blood-glucose regulation. It is
well established that an elevation of glucose concentration reduces secretion of the …

Insulin signaling is mediated by a complex network of diverging and converging pathways,
with alternative proteins and isoforms at almost every step in the process. We show here that …

Type I diabetes [insulin-dependent diabetes mellitus (IDDM)] is an autoimmune disease
associated with the destruction of pancreatic β cells. Serum from patients with IDDM increased L-…

An oscillatory increase in pancreatic β cell cytoplasmic free Ca 2+ concentration, [Ca 2+ ] i ,
is a key feature in glucose-induced insulin release. The role of the voltage-gated Ca 2+ …

Inositol pyrophosphates are recognized components of cellular processes that regulate vesicle
trafficking, telomere length, and apoptosis. We observed that pancreatic β cells maintain …

An important feature of glucose homeostasis is the effective release of glucagon from the
pancreatic α cell. The molecular mechanisms regulating glucagon secretion are still poorly …

The appropriate function of insulin-producing pancreatic β-cells is crucial for the regulation
of glucose homeostasis, and its impairment leads to diabetes mellitus, the most common …