The synergism between c-MYC and miR-17-19b, a truncated version of the miR-17-92
cluster, is well-documented during tumor initiation. However, little is known about miR-17-19b …

Protein methylation is a post-translational modification (PTM) by which a variable number of
methyl groups are transferred to lysine and arginine residues within proteins. Despite …

The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment
response has hampered the development of new therapies for amyotrophic lateral sclerosis (…

No single-omic approach completely elucidates the multitude of alterations taking place in
Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic …

Background It is unclear to what extent pre-clinical studies in genetically homogeneous
animal models of amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative …

The granin neuropeptide family is composed of acidic secretory signaling molecules that act
throughout the nervous system to help modulate synaptic signaling and neural activity. …

Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality
globally. Although mild therapeutic hypothermia (TH) may improve outcomes in selected …

Plasma proteome composition reflects the inflammatory and metabolic state of the organism
and can be predictive of system-level and organ-specific pathologies. Circulating protein …

Protein aggregation in biofluids is a poorly understood phenomenon. Under normal
physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to …

Chromatin is a highly structured nucleoprotein complex made of histone proteins and DNA
that controls nearly all DNA-dependent processes. Chromatin plasticity is regulated by …