The appropriate function of insulin-producing pancreatic β-cells is crucial for the regulation
of glucose homeostasis, and its impairment leads to diabetes mellitus, the most common …

Insulin signaling is mediated by a complex network of diverging and converging pathways,
with alternative proteins and isoforms at almost every step in the process. We show here that …

The control of glucose homeostasis by insulin requires, in addition to the glucose-induced
insulin release, a highly dynamic control of insulin biosynthesis. Although elevated glucose …

Phosphatidylinositide 3‐kinases (PI3Ks) play central roles in insulin signal transduction. While
the contribution of class Ia PI3K members has been extensively studied, the role of class II …

A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure,
which results in insulinopenia and hyperglycemia. We show that the adipokine adipsin has …

Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its
impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from …

Advanced imaging techniques have become a valuable tool in the study of complex biological
processes at the cellular level in biomedical research. Here, we introduce a new technical …

Oxidative stress is induced in pancreatic β-cells under diabetic conditions and causes β-cell
dysfunction. Antioxidant treatment of diabetic animals leads to recovery of insulin …

An oscillatory increase in pancreatic β cell cytoplasmic free Ca 2+ concentration, [Ca 2+ ] i ,
is a key feature in glucose-induced insulin release. The role of the voltage-gated Ca 2+ …

Glucose stimulation of pancreatic β-cells leads to insulin secretion as well as up-regulation
of insulin biosynthesis. The acute elevation in pro-insulin levels is thought to be exclusively …