User profiles for Dong Chen
 | Chen DongVerified email at tsinghua.edu.cn Cited by 63769 |
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and
function have remained unclear. Here we have evaluated in vitro and in vivo the …
function have remained unclear. Here we have evaluated in vitro and in vivo the …
Two-photon excitation fluorescence microscopy
PTC So, CY Dong, BR Masters… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Two-photon fluorescence microscopy is one of the most important recent inventions
in biological imaging. This technology enables noninvasive study of biological specimens …
in biological imaging. This technology enables noninvasive study of biological specimens …
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
After activation, CD4 + helper T (Th) cells differentiate into distinct effector subsets. Although
chemokine (CXC motif) receptor 5-expressing T follicular helper (Tfh) cells are important in …
chemokine (CXC motif) receptor 5-expressing T follicular helper (Tfh) cells are important in …
[HTML][HTML] Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals
The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide
pandemic. However, there is very limited understanding on the immune responses, especially …
pandemic. However, there is very limited understanding on the immune responses, especially …
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
After activation, CD4 + helper T (T H ) cells differentiate into distinct effector subsets that are
characterized by their unique cytokine expression and immunoregulatory function 1 , 2 . …
characterized by their unique cytokine expression and immunoregulatory function 1 , 2 . …
TH17 cells in development: an updated view of their molecular identity and genetic programming
C Dong - Nature Reviews Immunology, 2008 - nature.com
Following activation, CD4 + T cells differentiate into different lineages of helper T (T H ) cells
that are characterized by distinct developmental regulation and biological functions. T H 17 …
that are characterized by distinct developmental regulation and biological functions. T H 17 …
Bcl6 mediates the development of T follicular helper cells
…, S Tanaka, TD Matskevitch, YH Wang, C Dong - Science, 2009 - science.org
A fundamental function of CD4 + helper T (T H ) cells is the regulation of B cell–mediated
humoral immunity. Development of T follicular helper (T FH ) cells that provide help to B cells is …
humoral immunity. Development of T follicular helper (T FH ) cells that provide help to B cells is …
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we
show that interleukin-1 (IL-1) signaling on T cells is critically required for the early …
show that interleukin-1 (IL-1) signaling on T cells is critically required for the early …
Defective T Cell Differentiation in the Absence of Jnk1
The c-Jun NH 2 -terminal kinase (JNK) signaling pathway has been implicated in the immune
response that is mediated by the activation and differentiation of CD4 helper T (T H ) cells …
response that is mediated by the activation and differentiation of CD4 helper T (T H ) cells …
[HTML][HTML] T helper 17 cells promote cytotoxic T cell activation in tumor immunity
Although T helper 17 (Th17) cells have been found in tumor tissues, their function in cancer
immunity is unclear. We found that interleukin-17A (IL-17A)-deficient mice were more …
immunity is unclear. We found that interleukin-17A (IL-17A)-deficient mice were more …