Mesolimbic dopamine signals the value of work

AA Hamid, JR Pettibone, OS Mabrouk, VL Hetrick… - Nature …, 2016 - nature.com
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …

The current state-of-the art of LRRK2-based biomarker assay development in Parkinson's disease

HJ Rideout, MC Chartier-Harlin, MJ Fell… - Frontiers in …, 2020 - frontiersin.org
Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in
multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to …

In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography–mass spectrometry

P Song, OS Mabrouk, ND Hershey… - Analytical …, 2012 - ACS Publications
In vivo neurochemical monitoring using microdialysis sampling is important in neuroscience
because it allows correlation of neurotransmission with behavior, disease state, and drug …

Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples

JMT Wong, PA Malec, OS Mabrouk, J Ro, M Dus… - … of Chromatography A, 2016 - Elsevier
Widely targeted metabolomic assays are useful because they provide quantitative data on
large groups of related compounds. We report a high performance liquid chromatography …

Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress-and drug-induced dopamine release in the rat medial prefrontal cortex

EA Pehek, C Nocjar, BL Roth, TA Byrd… - …, 2006 - nature.com
The mechanism (s) by which serotonin modulates dopamine release in the medial prefrontal
cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We …

LRRK2 inhibition by BIIB122 in healthy participants and patients with Parkinson's disease

D Jennings, S Huntwork‐Rodriguez… - Movement …, 2023 - Wiley Online Library
Background Leucine‐rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was …

Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery

CM Vander Weele, KA Porter‐Stransky… - European Journal of …, 2014 - Wiley Online Library
While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical
measurements show that different drugs evoke distinct dopamine release patterns within the …

[HTML][HTML] Enkephalin surges in dorsal neostriatum as a signal to eat

AG DiFeliceantonio, OS Mabrouk, RT Kennedy… - Current Biology, 2012 - cell.com
Compulsive overconsumption of reward characterizes disorders ranging from binge eating
to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial …

Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

SS Pappas, K Darr, SM Holley, C Cepeda, OS Mabrouk… - Elife, 2015 - elifesciences.org
Striatal dysfunction plays an important role in dystonia, but the striatal cell types that
contribute to abnormal movements are poorly defined. We demonstrate that conditional …

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

F Longo, D Mercatelli, S Novello, L Arcuri… - Acta neuropathologica …, 2017 - Springer
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson's disease. Here, we investigated whether the G2019S LRRK2 mutation …