Mesolimbic dopamine signals the value of work
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
The current state-of-the art of LRRK2-based biomarker assay development in Parkinson's disease
HJ Rideout, MC Chartier-Harlin, MJ Fell… - Frontiers in …, 2020 - frontiersin.org
Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in
multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to …
multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to …
In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography–mass spectrometry
In vivo neurochemical monitoring using microdialysis sampling is important in neuroscience
because it allows correlation of neurotransmission with behavior, disease state, and drug …
because it allows correlation of neurotransmission with behavior, disease state, and drug …
Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples
Widely targeted metabolomic assays are useful because they provide quantitative data on
large groups of related compounds. We report a high performance liquid chromatography …
large groups of related compounds. We report a high performance liquid chromatography …
Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress-and drug-induced dopamine release in the rat medial prefrontal cortex
The mechanism (s) by which serotonin modulates dopamine release in the medial prefrontal
cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We …
cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We …
LRRK2 inhibition by BIIB122 in healthy participants and patients with Parkinson's disease
D Jennings, S Huntwork‐Rodriguez… - Movement …, 2023 - Wiley Online Library
Background Leucine‐rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was …
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was …
Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery
CM Vander Weele, KA Porter‐Stransky… - European Journal of …, 2014 - Wiley Online Library
While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical
measurements show that different drugs evoke distinct dopamine release patterns within the …
measurements show that different drugs evoke distinct dopamine release patterns within the …
[HTML][HTML] Enkephalin surges in dorsal neostriatum as a signal to eat
AG DiFeliceantonio, OS Mabrouk, RT Kennedy… - Current Biology, 2012 - cell.com
Compulsive overconsumption of reward characterizes disorders ranging from binge eating
to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial …
to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial …
Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons
Striatal dysfunction plays an important role in dystonia, but the striatal cell types that
contribute to abnormal movements are poorly defined. We demonstrate that conditional …
contribute to abnormal movements are poorly defined. We demonstrate that conditional …
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson's disease. Here, we investigated whether the G2019S LRRK2 mutation …
cause of Parkinson's disease. Here, we investigated whether the G2019S LRRK2 mutation …