Targeting Treg signaling for the treatment of autoimmune diseases
A Spence, JE Klementowicz, JA Bluestone… - Current opinion in …, 2015 - Elsevier
Highlights•Role of TCR, CD28, and IL2 in Treg identity and function.•Impact of PI3K-Akt-
mTOR signaling on Treg development, homeostasis, and function.•Importance of …
mTOR signaling on Treg development, homeostasis, and function.•Importance of …
New insights into the mechanisms of Treg function
DM Rothstein, G Camirand - Current opinion in organ …, 2015 - journals.lww.com
Tregs exhibit a previously unrecognized breadth of function, which includes tissue-specific
specialization and the regulation of both immune and nonimmune processes. This is of …
specialization and the regulation of both immune and nonimmune processes. This is of …
[HTML][HTML] Selective FcγR co-engagement on APCs modulates the activity of therapeutic antibodies targeting T cell antigens
The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc
region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to …
region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to …
[HTML][HTML] Antigen-dependent interactions between regulatory B cells and T cells at the T: B border inhibit subsequent T cell interactions with DCs
K Mohib, A Cherukuri, Y Zhou, Q Ding… - American Journal of …, 2020 - Elsevier
IL-10+ regulatory B cells (Bregs) inhibit immune responses in various settings. While Bregs
appear to inhibit inflammatory cytokine expression by CD4+ T cells and innate immune cells …
appear to inhibit inflammatory cytokine expression by CD4+ T cells and innate immune cells …
[HTML][HTML] Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice
CS Wilson, BT Stocks, EM Hoopes, JP Rhoads… - JCI insight, 2021 - ncbi.nlm.nih.gov
Autoimmune disease has presented an insurmountable barrier to restoration of durable
immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors …
immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors …
Divergent CD4+ T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients
M Khelfa, M Leclerc, S Kerbrat… - Frontiers in …, 2023 - frontiersin.org
Introduction Acute myeloid leukemia (AML) is one of the commonest hematologic disorders.
Due to the high frequency of disease-or treatment-related thrombocytopenia, AML requires …
Due to the high frequency of disease-or treatment-related thrombocytopenia, AML requires …
Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes
YL Li, CH Chen, JY Chen, YS Lai, SC Wang… - …, 2020 - Taylor & Francis
Lymph-node metastasis is a prognosis factor for poor clinical outcome of breast cancer
patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor …
patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor …
CD11c-expressing cells affect regulatory T cell behavior in the meninges during central nervous system infection
CA O'Brien, C Overall, C Konradt… - The Journal of …, 2017 - journals.aai.org
Regulatory T cells (Tregs) play an important role in the CNS during multiple infections, as
well as autoimmune inflammation, but the behavior of this cell type in the CNS has not been …
well as autoimmune inflammation, but the behavior of this cell type in the CNS has not been …
[HTML][HTML] The promise of CD4+ FoxP3+ regulatory T-cell manipulation in vivo: applications for allogeneic hematopoietic stem cell transplantation
S Copsel, D Wolf, KV Komanduri, RB Levy - Haematologica, 2019 - ncbi.nlm.nih.gov
Abstract CD4+ FoxP3+ regulatory T cells (Tregs) are a non-redundant population critical for
the maintenance of self-tolerance. Over the past decade, the use of these cells for …
the maintenance of self-tolerance. Over the past decade, the use of these cells for …
Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome
E Pollenus, H Possemiers, S Knoops, F Prenen… - Plos …, 2024 - journals.plos.org
Plasmodium parasites cause malaria, a global health disease that is responsible for more
than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by …
than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by …