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Extract from the Register of European Patents

EP About this file: EP2361970

EP2361970 - Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  18.03.2016
Database last updated on 04.02.2025
Most recent event   Tooltip18.03.2016Application deemed to be withdrawnpublished on 20.04.2016  [2016/16]
Applicant(s)For all designated states
Mesoblast, Inc.
275 Madison Avenue 4th Floor
New York NY 10016 / US
[2012/20]
Former [2011/35]For all designated states
Angioblast Systems Incorporated
275 Madison Avenue, Suite 414
New York, NY 10016 / US
Inventor(s)01 / Gronthos, Stan
21 Light Place
Colonel Light Gardens
Adelaide, South Australia 5041 / AU
02 / Zannettino, Andrew, Christopher, William
6 Domain Commons
Highbury, South Australia 5089 / AU
 [2011/35]
Representative(s)O'Neill, Michelle
Harrison IP Limited
3 Ebor House
London Ebor Business Park
Millfield Lane
Nether Poppleton York YO26 6QY / GB
[N/P]
Former [2011/35]O'Neill, Michelle
Harrison IP Limited Marlborough House Westminster Place York Business Park
Nether Poppleton, York YO26 6RW / GB
Application number, filing date10075543.829.06.2005
[2011/35]
Priority number, dateUS2004061302124.09.2004         Original published format: US 613021
[2011/35]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2361970
Date:31.08.2011
Language:EN
[2011/35]
Search report(s)(Supplementary) European search report - dispatched on:EP26.05.2011
ClassificationIPC:C12N5/0775, A61K35/12, A61K35/28, A61P9/00
[2011/35]
CPC:
C12N5/0663 (EP,KR,US); C12N5/0652 (KR,US); A61P1/02 (EP);
A61P19/00 (EP); A61P19/02 (EP); A61P19/08 (EP);
A61P19/10 (EP); A61P21/00 (EP); A61P29/00 (EP);
A61P43/00 (EP); A61P9/00 (EP); A61P9/10 (EP);
C12N2501/125 (KR,US); C12N2501/135 (KR,US); C12N2501/22 (KR,US);
C12N2501/2301 (KR,US); C12N2501/2303 (KR,US); C12N2501/2306 (KR,US);
C12N2501/25 (KR,US); C12N2501/999 (KR,US); C12N2502/13 (KR,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/35]
TitleGerman:Verfahren zur Verbesserung der Vermehrung und/oder des Überlebens von Mesenchymalvorläuferzellen (MPC)[2011/35]
English:Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)[2011/35]
French:Procédé d'amélioration de la prolifération et/ou survie des cellules de précurseurs mesenchymataux (MPC)[2011/35]
Examination procedure16.02.2012Amendment by applicant (claims and/or description)
16.02.2012Examination requested  [2012/14]
07.12.2012Despatch of a communication from the examining division (Time limit: M06)
10.06.2013Reply to a communication from the examining division
28.04.2015Despatch of a communication from the examining division (Time limit: M06)
10.11.2015Application deemed to be withdrawn, date of legal effect  [2016/16]
07.12.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2016/16]
Parent application(s)   TooltipEP05754008.0  / EP1807505
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050754008) is  01.04.2008
Fees paidRenewal fee
29.09.2010Renewal fee patent year 03
29.09.2010Renewal fee patent year 04
29.09.2010Renewal fee patent year 05
29.09.2010Renewal fee patent year 06
27.05.2011Renewal fee patent year 07
14.06.2012Renewal fee patent year 08
10.06.2013Renewal fee patent year 09
31.03.2014Renewal fee patent year 10
10.06.2015Renewal fee patent year 11
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Documents cited:Search[X]WO2004052177  (UNIV CASE WESTERN RESERVE [US], et al) [X] 1-6,8,9,12-17 * page 18 - page 20 * * page 21 *;
 [X]  - BROXMEYER HAL E ET AL, "Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo.", JOURNAL OF IMMUNOLOGY, (20030101), vol. 170, no. 1, ISSN 0022-1767, pages 421 - 429, XP002635947 [X] 1-3,7-9,12-17 * page 422 - page 425 *
 [Y]  - LATAILLADE JEAN-JACQUES ET AL, "Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: Possible role in progenitor survival", BLOOD, (20000201), vol. 95, no. 3, ISSN 0006-4971, pages 756 - 768, XP002635562 [Y] 1-18 * page 763 - page 767 *
 [Y]  - HODOHARA KEIKO ET AL, "Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK)", BLOOD, (20000201), vol. 95, no. 3, ISSN 0006-4971, pages 769 - 775, XP002635948 [Y] 1-18 * page 769 *
 [Y]  - PONOMARYOV TANYA ET AL, "Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function", JOURNAL OF CLINICAL INVESTIGATION, (200012), vol. 106, no. 11, ISSN 0021-9738, pages 1331 - 1339, XP002635949 [Y] 1-18 * page 1332 *

DOI:   http://dx.doi.org/10.1172/JCI10329
 [Y]  - NEUHAUS THOMAS ET AL, "Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation.", CELL PROLIFERATION APR 2003 LNKD- PUBMED:12680875, (200304), vol. 36, no. 2, ISSN 0960-7722, pages 75 - 86, XP002635950 [Y] 1-18 * page 75 *

DOI:   http://dx.doi.org/10.1046/j.1365-2184.2003.00262.x
Examination   - KORTESIDIS A ET AL, "Stromal-derived factor-1 promotes the growth, survival, and developme", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20050515), vol. 105, no. 10, doi:10.1182/BLOOD-2004-11-4349, ISSN 0006-4971, pages 3793 - 3801, XP003019018

DOI:   http://dx.doi.org/10.1182/blood-2004-11-4349
by applicantUS4352883
 US4963489
 US5226914
 WO9429438
 WO9527071
 WO9605309
 US5563048
 WO9721824
 WO9721825
 US5691176
 US5693531
 US5756084
 US5827735
 US5837539
 WO0104268
 US6200606
 US2002022676
 US6355699
 WO2004085630
 US2005059584
 US2005065064
    - WRIGHT ET AL., BONE, (2005), vol. 36, pages 840 - 853
    - ZANNETTINO ET AL., CANCER RES, (2005), vol. 65, no. 5, pages 1700 - 1709
    - GRASSI ET AL., J. CELL. PHYSIOL., (2004), vol. 199, pages 244 - 251
    - LOETSCHER ET AL., J. BIOL. CHEM, (1994), vol. 269, pages 232 - 237
    - FEDERSPPIEL ET AL., GENOMICS, (1993), vol. 16, pages 707 - 712
    - FENG ET AL., SCIENCE, (1996), vol. 272, pages 872 - 877
    - CRUMP ET AL., EMBO J., (1997), vol. 16, pages 6996 - 7007
    - CRUMP ET AL., EMBO J, (1997), vol. 16, pages 6996 - 7007
    - FRIEDENSTEIN ET AL., EXP HEMATOL., (1978), vol. 6, pages 440 - 444
    - KUZNETSOV ET AL., J BONE MINER RES., (1997), vol. 12, pages 1335 - 1347
    - PITTENGER ET AL., SCIENCE, (1999), vol. 284, pages 143 - 147
    - BIANCO ET AL., STEM CELLS, (2001), vol. 19, pages 180 - 192
    - GRONTHOS ET AL., J CELL SCI., (2003), vol. 116, pages 1827 - 1835
    - LIECHTY ET AL., NAT MED., (2000), vol. 6, pages 1282 - 1286
    - ZHAO ET AL., EXP NEUROL., (2002), vol. 174, pages 11 - 20
    - VERFAILLIE ET AL., ANN N Y ACAD SCI., (2003), vol. 996, pages 231 - 234
    - GRONTHOS, BLOOD, (1994), vol. 84, pages 4164 - 73
    - SHIROZU ET AL., GENOMICS, (1995), vol. 28, page 495
    - TASHIRO ET AL., SCIENCE, (1993), vol. 261, page 600
    - NISHIMURA ET AL., EUR. J. IMMUNOGENET., (1998), vol. 25, page 303
    - PELUS ET AL., EXP. HEMATOL., (2005), vol. 33, page 295
    - TRAN ET AL., J. NEUROIMMUNOL., (2005), vol. 160, page 68
    - ZHANG ET AL., J. BIOL. CHEM., (2002), vol. 277, page 24515
    - BREGNI ET AL., BLOOD, (1992), vol. 80, pages 1418 - 1422
    - XU ET AL., EXP. HEMAT., (1994), vol. 22, pages 223 - 230
    - COFFIN ET AL., Retroviruses, COLD SPRINGS HARBOR LABORATORY PRESS, (1997), pages 437 - 473
    - CHANG ET AL., BLOOD, (1998), vol. 92, pages 1 - 11
    - AGARWAL ET AL., J. OF VIROLOGY, (1998), vol. 72, pages 3720 - 3728
    - MILLER ET AL., MOL. CELL BIOL., (1986), vol. 6, page 2895
    - MILLER ET AL., BIOTECHNIQUES, (1989), vol. 7, page 980
    - DANOS ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, page 6460
    - PEAR ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 8392 - 8396
    - FINER ET AL., BLOOD, (1994), vol. 83, pages 43 - 50
    - FREY ET AL., BLOOD, (1998), vol. 91, page 2781
    - CHATTERJEE ET AL., CURRENT TOPICS IN MICROBIOL. AND IMMUNOL., (1996), vol. 218, pages 61 - 73
    - UNKNWON, Pharmaceutical Sciences 17.sup.th Ed.,, MACK PUB. CO.
    - ANSETH ET AL., J. CONTROL RELEASE, (2002), vol. 78, no. 1-3, pages 199 - 209
    - WANG ET AL., BIOMATERIALS, (2003), vol. 24, no. 22, pages 3969 - 80
    - ALLCOCK ET AL., MACROMOLECULE, (1977), vol. 10, page 824
    - HUTMACHER, J. BIOMAT. SCI. POLYMER EDN., (2001), vol. 12, no. 1, pages 107 - 124
    - "Isolation, Purification and In Vitro Manipulation of Human Bone Marrow Stromal Precursor Cells", GRONTHOS ET AL., Marrow Stromal Cell Culture, CAMBRIDGE UNIVERSITY PRESS, (1998), pages 26 - 42
    - GRONTHOS; SIMMONS, BLOOD, (1995), vol. 85, no. 4, pages 929 - 940
    - GRONTHOS ET AL., J. BONE AND MIN. RES., (1999), vol. 14, pages 48 - 57
    - GRONTHOS ET AL., BLOOD, (1994), vol. 84, pages 4164 - 4173
    - "Marrow stromal adipocytes", GIMBLE, J. M., Marrow stromal cell culture, CAMBRIDGE: CAMBRIDGE UNIVERSITY PRESS, (1998), pages 67 - 87
    - GRONTHOS ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA), (2000), vol. 97, no. 25, pages 13625 - 13630
    - GRONTHOS; SIMMONS, BLOOD, (1995), vol. 85, pages 929 - 940
    - GRONTHOS ET AL., J BONE MINER RES., (1999), vol. 14, pages 47 - 56
    - PAN ET AL., BONE, (2004), vol. 34, no. 1, pages 112 - 23
    - ATKINS ET AL., J BONE MINER RES., (2003), vol. 18, no. 6, pages 1088 - 98
    - GRYNKIEWICZ ET AL., J BIOL CHEM., (1985), vol. 260, pages 3440 - 3450
    - SHI ET AL., NAT BIOTECHNOL, (2002), vol. 20, pages 587 - 591
    - GRONTHOS ET AL., J. CELL SCI, (2003), vol. 116, pages 1827 - 1835
    - SHI; GRONTHOS, JBMR, (2003), vol. 18, no. 4, pages 696 - 704
    - XU ET AL., CANCER RES., (2000), vol. 60, pages 1677 - 1682
    - KINGSLEY ET AL., DEV GROWTH DIFFER., (2001), vol. 43, pages 133 - 143
    - STEWART ET AL., J BONE MINER RES., (1999), vol. 14, pages 1345 - 1356
    - GUPTA; PILLARISETTI, J IMMUNOL., (1999), vol. 163, pages 2368 - 2372
    - WANG ET AL., AM J HEMATOL., (1992), vol. 40, pages 81 - 85
    - SHI; GRONTHOS, J BONE MINER RES., (2003), vol. 18, pages 696 - 704
    - PONOMARYOV ET AL., J CLIN INVEST., (2000), vol. 106, pages 1331 - 1339
    - PETIT ET AL., NAT IMMUNOL., (2002), vol. 3, pages 687 - 694
    - SALVUCCI ET AL., BLOOD, (2002), vol. 99, pages 2703 - 2711
    - BLEUL ET AL., NATURE, (1996), vol. 382, pages 829 - 833
    - OBERLIN ET AL., NATURE, (1996), vol. 382, pages 833 - 835
    - MA ET AL., PROC NATL ACAD SCI U S A., (1998), vol. 95, pages 9448 - 9453
    - GUPTA ET AL., J IMMUNOL., (1999), vol. 163, pages 2368 - 2372
 WO2005AU00416
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