EP2361970 - Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 18.03.2016 Database last updated on 04.02.2025 | Most recent event Tooltip | 18.03.2016 | Application deemed to be withdrawn | published on 20.04.2016 [2016/16] | Applicant(s) | For all designated states Mesoblast, Inc. 275 Madison Avenue 4th Floor New York NY 10016 / US | [2012/20] |
Former [2011/35] | For all designated states Angioblast Systems Incorporated 275 Madison Avenue, Suite 414 New York, NY 10016 / US | Inventor(s) | 01 /
Gronthos, Stan 21 Light Place Colonel Light Gardens Adelaide, South Australia 5041 / AU | 02 /
Zannettino, Andrew, Christopher, William 6 Domain Commons Highbury, South Australia 5089 / AU | [2011/35] | Representative(s) | O'Neill, Michelle Harrison IP Limited 3 Ebor House London Ebor Business Park Millfield Lane Nether Poppleton York YO26 6QY / GB | [N/P] |
Former [2011/35] | O'Neill, Michelle Harrison IP Limited Marlborough House Westminster Place York Business Park Nether Poppleton, York YO26 6RW / GB | Application number, filing date | 10075543.8 | 29.06.2005 | [2011/35] | Priority number, date | US20040613021 | 24.09.2004 Original published format: US 613021 | [2011/35] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2361970 | Date: | 31.08.2011 | Language: | EN | [2011/35] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 26.05.2011 | Classification | IPC: | C12N5/0775, A61K35/12, A61K35/28, A61P9/00 | [2011/35] | CPC: |
C12N5/0663 (EP,KR,US);
C12N5/0652 (KR,US);
A61P1/02 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P19/10 (EP);
A61P21/00 (EP);
A61P29/00 (EP);
A61P43/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
C12N2501/125 (KR,US);
C12N2501/135 (KR,US);
C12N2501/22 (KR,US);
C12N2501/2301 (KR,US);
C12N2501/2303 (KR,US);
C12N2501/2306 (KR,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2011/35] | Title | German: | Verfahren zur Verbesserung der Vermehrung und/oder des Überlebens von Mesenchymalvorläuferzellen (MPC) | [2011/35] | English: | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) | [2011/35] | French: | Procédé d'amélioration de la prolifération et/ou survie des cellules de précurseurs mesenchymataux (MPC) | [2011/35] | Examination procedure | 16.02.2012 | Amendment by applicant (claims and/or description) | 16.02.2012 | Examination requested [2012/14] | 07.12.2012 | Despatch of a communication from the examining division (Time limit: M06) | 10.06.2013 | Reply to a communication from the examining division | 28.04.2015 | Despatch of a communication from the examining division (Time limit: M06) | 10.11.2015 | Application deemed to be withdrawn, date of legal effect [2016/16] | 07.12.2015 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2016/16] | Parent application(s) Tooltip | EP05754008.0 / EP1807505 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050754008) is 01.04.2008 | Fees paid | Renewal fee | 29.09.2010 | Renewal fee patent year 03 | 29.09.2010 | Renewal fee patent year 04 | 29.09.2010 | Renewal fee patent year 05 | 29.09.2010 | Renewal fee patent year 06 | 27.05.2011 | Renewal fee patent year 07 | 14.06.2012 | Renewal fee patent year 08 | 10.06.2013 | Renewal fee patent year 09 | 31.03.2014 | Renewal fee patent year 10 | 10.06.2015 | Renewal fee patent year 11 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X]WO2004052177 (UNIV CASE WESTERN RESERVE [US], et al) [X] 1-6,8,9,12-17 * page 18 - page 20 * * page 21 *; | [X] - BROXMEYER HAL E ET AL, "Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo.", JOURNAL OF IMMUNOLOGY, (20030101), vol. 170, no. 1, ISSN 0022-1767, pages 421 - 429, XP002635947 [X] 1-3,7-9,12-17 * page 422 - page 425 * | [Y] - LATAILLADE JEAN-JACQUES ET AL, "Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: Possible role in progenitor survival", BLOOD, (20000201), vol. 95, no. 3, ISSN 0006-4971, pages 756 - 768, XP002635562 [Y] 1-18 * page 763 - page 767 * | [Y] - HODOHARA KEIKO ET AL, "Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK)", BLOOD, (20000201), vol. 95, no. 3, ISSN 0006-4971, pages 769 - 775, XP002635948 [Y] 1-18 * page 769 * | [Y] - PONOMARYOV TANYA ET AL, "Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function", JOURNAL OF CLINICAL INVESTIGATION, (200012), vol. 106, no. 11, ISSN 0021-9738, pages 1331 - 1339, XP002635949 [Y] 1-18 * page 1332 * DOI: http://dx.doi.org/10.1172/JCI10329 | [Y] - NEUHAUS THOMAS ET AL, "Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation.", CELL PROLIFERATION APR 2003 LNKD- PUBMED:12680875, (200304), vol. 36, no. 2, ISSN 0960-7722, pages 75 - 86, XP002635950 [Y] 1-18 * page 75 * DOI: http://dx.doi.org/10.1046/j.1365-2184.2003.00262.x | Examination | - KORTESIDIS A ET AL, "Stromal-derived factor-1 promotes the growth, survival, and developme", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20050515), vol. 105, no. 10, doi:10.1182/BLOOD-2004-11-4349, ISSN 0006-4971, pages 3793 - 3801, XP003019018 DOI: http://dx.doi.org/10.1182/blood-2004-11-4349 | by applicant | US4352883 | US4963489 | US5226914 | WO9429438 | WO9527071 | WO9605309 | US5563048 | WO9721824 | WO9721825 | US5691176 | US5693531 | US5756084 | US5827735 | US5837539 | WO0104268 | US6200606 | US2002022676 | US6355699 | WO2004085630 | US2005059584 | US2005065064 | - WRIGHT ET AL., BONE, (2005), vol. 36, pages 840 - 853 | - ZANNETTINO ET AL., CANCER RES, (2005), vol. 65, no. 5, pages 1700 - 1709 | - GRASSI ET AL., J. CELL. PHYSIOL., (2004), vol. 199, pages 244 - 251 | - LOETSCHER ET AL., J. BIOL. CHEM, (1994), vol. 269, pages 232 - 237 | - FEDERSPPIEL ET AL., GENOMICS, (1993), vol. 16, pages 707 - 712 | - FENG ET AL., SCIENCE, (1996), vol. 272, pages 872 - 877 | - CRUMP ET AL., EMBO J., (1997), vol. 16, pages 6996 - 7007 | - CRUMP ET AL., EMBO J, (1997), vol. 16, pages 6996 - 7007 | - FRIEDENSTEIN ET AL., EXP HEMATOL., (1978), vol. 6, pages 440 - 444 | - KUZNETSOV ET AL., J BONE MINER RES., (1997), vol. 12, pages 1335 - 1347 | - PITTENGER ET AL., SCIENCE, (1999), vol. 284, pages 143 - 147 | - BIANCO ET AL., STEM CELLS, (2001), vol. 19, pages 180 - 192 | - GRONTHOS ET AL., J CELL SCI., (2003), vol. 116, pages 1827 - 1835 | - LIECHTY ET AL., NAT MED., (2000), vol. 6, pages 1282 - 1286 | - ZHAO ET AL., EXP NEUROL., (2002), vol. 174, pages 11 - 20 | - VERFAILLIE ET AL., ANN N Y ACAD SCI., (2003), vol. 996, pages 231 - 234 | - GRONTHOS, BLOOD, (1994), vol. 84, pages 4164 - 73 | - SHIROZU ET AL., GENOMICS, (1995), vol. 28, page 495 | - TASHIRO ET AL., SCIENCE, (1993), vol. 261, page 600 | - NISHIMURA ET AL., EUR. J. IMMUNOGENET., (1998), vol. 25, page 303 | - PELUS ET AL., EXP. HEMATOL., (2005), vol. 33, page 295 | - TRAN ET AL., J. NEUROIMMUNOL., (2005), vol. 160, page 68 | - ZHANG ET AL., J. BIOL. CHEM., (2002), vol. 277, page 24515 | - BREGNI ET AL., BLOOD, (1992), vol. 80, pages 1418 - 1422 | - XU ET AL., EXP. HEMAT., (1994), vol. 22, pages 223 - 230 | - COFFIN ET AL., Retroviruses, COLD SPRINGS HARBOR LABORATORY PRESS, (1997), pages 437 - 473 | - CHANG ET AL., BLOOD, (1998), vol. 92, pages 1 - 11 | - AGARWAL ET AL., J. OF VIROLOGY, (1998), vol. 72, pages 3720 - 3728 | - MILLER ET AL., MOL. CELL BIOL., (1986), vol. 6, page 2895 | - MILLER ET AL., BIOTECHNIQUES, (1989), vol. 7, page 980 | - DANOS ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, page 6460 | - PEAR ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 8392 - 8396 | - FINER ET AL., BLOOD, (1994), vol. 83, pages 43 - 50 | - FREY ET AL., BLOOD, (1998), vol. 91, page 2781 | - CHATTERJEE ET AL., CURRENT TOPICS IN MICROBIOL. AND IMMUNOL., (1996), vol. 218, pages 61 - 73 | - UNKNWON, Pharmaceutical Sciences 17.sup.th Ed.,, MACK PUB. CO. | - ANSETH ET AL., J. CONTROL RELEASE, (2002), vol. 78, no. 1-3, pages 199 - 209 | - WANG ET AL., BIOMATERIALS, (2003), vol. 24, no. 22, pages 3969 - 80 | - ALLCOCK ET AL., MACROMOLECULE, (1977), vol. 10, page 824 | - HUTMACHER, J. BIOMAT. SCI. POLYMER EDN., (2001), vol. 12, no. 1, pages 107 - 124 | - "Isolation, Purification and In Vitro Manipulation of Human Bone Marrow Stromal Precursor Cells", GRONTHOS ET AL., Marrow Stromal Cell Culture, CAMBRIDGE UNIVERSITY PRESS, (1998), pages 26 - 42 | - GRONTHOS; SIMMONS, BLOOD, (1995), vol. 85, no. 4, pages 929 - 940 | - GRONTHOS ET AL., J. BONE AND MIN. RES., (1999), vol. 14, pages 48 - 57 | - GRONTHOS ET AL., BLOOD, (1994), vol. 84, pages 4164 - 4173 | - "Marrow stromal adipocytes", GIMBLE, J. M., Marrow stromal cell culture, CAMBRIDGE: CAMBRIDGE UNIVERSITY PRESS, (1998), pages 67 - 87 | - GRONTHOS ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA), (2000), vol. 97, no. 25, pages 13625 - 13630 | - GRONTHOS; SIMMONS, BLOOD, (1995), vol. 85, pages 929 - 940 | - GRONTHOS ET AL., J BONE MINER RES., (1999), vol. 14, pages 47 - 56 | - PAN ET AL., BONE, (2004), vol. 34, no. 1, pages 112 - 23 | - ATKINS ET AL., J BONE MINER RES., (2003), vol. 18, no. 6, pages 1088 - 98 | - GRYNKIEWICZ ET AL., J BIOL CHEM., (1985), vol. 260, pages 3440 - 3450 | - SHI ET AL., NAT BIOTECHNOL, (2002), vol. 20, pages 587 - 591 | - GRONTHOS ET AL., J. CELL SCI, (2003), vol. 116, pages 1827 - 1835 | - SHI; GRONTHOS, JBMR, (2003), vol. 18, no. 4, pages 696 - 704 | - XU ET AL., CANCER RES., (2000), vol. 60, pages 1677 - 1682 | - KINGSLEY ET AL., DEV GROWTH DIFFER., (2001), vol. 43, pages 133 - 143 | - STEWART ET AL., J BONE MINER RES., (1999), vol. 14, pages 1345 - 1356 | - GUPTA; PILLARISETTI, J IMMUNOL., (1999), vol. 163, pages 2368 - 2372 | - WANG ET AL., AM J HEMATOL., (1992), vol. 40, pages 81 - 85 | - SHI; GRONTHOS, J BONE MINER RES., (2003), vol. 18, pages 696 - 704 | - PONOMARYOV ET AL., J CLIN INVEST., (2000), vol. 106, pages 1331 - 1339 | - PETIT ET AL., NAT IMMUNOL., (2002), vol. 3, pages 687 - 694 | - SALVUCCI ET AL., BLOOD, (2002), vol. 99, pages 2703 - 2711 | - BLEUL ET AL., NATURE, (1996), vol. 382, pages 829 - 833 | - OBERLIN ET AL., NATURE, (1996), vol. 382, pages 833 - 835 | - MA ET AL., PROC NATL ACAD SCI U S A., (1998), vol. 95, pages 9448 - 9453 | - GUPTA ET AL., J IMMUNOL., (1999), vol. 163, pages 2368 - 2372 | WO2005AU00416 |