History of childhood emotional abuse predicts lower resting-state high-frequency heart rate variability in depressed women

Psychiatry Res. 2018 Nov:269:681-687. doi: 10.1016/j.psychres.2018.08.106. Epub 2018 Aug 31.

Abstract

Childhood emotional abuse impairs emotion regulation and increases risk for major depressive disorder in adulthood. Mounting evidence suggests that decreased resting-state high-frequency heart rate variability, an index of parasympathetic function, represents a transdiagnostic biomarker of emotion dysregulation. We propose that adults with histories of major depressive disorder and childhood emotional abuse represent a subpopulation at particularly high risk to exhibit deficits in parasympathetic control. The current report compared resting-state high-frequency heart rate variability across three groups: (1) depressed women who endorsed childhood emotional abuse (N = 11); (2) depressed women without childhood emotional abuse (N = 19), and (3) never-depressed women without childhood emotional abuse (N = 22). Participants completed childhood trauma self-reports and assessment of resting-state high-frequency heart rate variability. ANCOVAs comparing the three groups after controlling for health-related, psychiatric, and respiratory factors were significant. Depressed women with childhood emotional abuse exhibited lower high-frequency heart rate variability than both groups without childhood emotional abuse (d's ranging from 0.81-0.92). Surprisingly, psychiatric factors were non-significant predictors, indicating that childhood emotional abuse may have a unique impact on autonomic functioning. Future research on larger samples is needed to disentangle the relative and synergistic burdens of depression and childhood trauma on physiologic indicators of emotion dysregulation.

Keywords: Childhood emotional abuse; Depression; High-frequency heart rate variability.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Child
  • Child Abuse* / psychology
  • Child Abuse* / trends
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / physiopathology*
  • Depressive Disorder, Major / psychology
  • Female
  • Heart Rate / physiology*
  • Humans
  • Middle Aged
  • Predictive Value of Tests
  • Rest / physiology*
  • Rest / psychology
  • Stress, Psychological / diagnosis
  • Stress, Psychological / physiopathology*
  • Stress, Psychological / psychology