Vitamin D(3): synthesis of seco C-9,11,21-trisnor-17-methyl-1 alpha, 25-dihydroxyvitamin D(3) analogues

Yusheng Wu; Katrien Sabbe; Pierre De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf

doi:10.1016/s0960-894x(02)00221-4

Vitamin D(3): synthesis of seco C-9,11,21-trisnor-17-methyl-1 alpha, 25-dihydroxyvitamin D(3) analogues

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1629-32. doi: 10.1016/s0960-894x(02)00221-4.

Authors

Yusheng Wu¹, Katrien Sabbe, Pierre De Clercq, Maurits Vandewalle, Roger Bouillon, Annemieke Verstuyf

Affiliation

¹ Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 S4, B-9000 Gent, Belgium.

PMID: 12039578
DOI: 10.1016/s0960-894x(02)00221-4

Abstract

The synthesis and biological activities of seco C-9,11,21-trisnor-17-methyl-1 alpha,25-dihydroxyvitamin D(3) analogues (D-ring analogues) are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cholecalciferol / analogs & derivatives*
Cholecalciferol / chemical synthesis*
Cholecalciferol / chemistry
Cholecalciferol / pharmacology*
Humans
Mice
Receptors, Calcitriol / drug effects
Swine

Substances

C-9,11,21-trisnor-17-methyl-1, 25-dihydroxyvitamin D3
Receptors, Calcitriol
Cholecalciferol