Noggin is a mesenchymally derived stimulator of hair-follicle induction

V A Botchkarev; N V Botchkareva; W Roth; M Nakamura; L H Chen; W Herzog; G Lindner; J A McMahon; C Peters; R Lauster; A P McMahon; R Paus

doi:10.1038/11078

Noggin is a mesenchymally derived stimulator of hair-follicle induction

Nat Cell Biol. 1999 Jul;1(3):158-64. doi: 10.1038/11078.

Authors

V A Botchkarev¹, N V Botchkareva, W Roth, M Nakamura, L H Chen, W Herzog, G Lindner, J A McMahon, C Peters, R Lauster, A P McMahon, R Paus

Affiliation

¹ Department of Dermatology, Charité, Humboldt-University Berlin, Germany.

PMID: 10559902
DOI: 10.1038/11078

Abstract

The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes the inhibitory action of BMP-4 and stimulates hair-follicle induction in embryonic skin organ culture. As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent downregulation of the 75 kD neurotrophin receptor in the developing hair follicle.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins / genetics
Carrier Proteins
Cell Adhesion Molecules / genetics
Gene Expression Regulation, Developmental*
Hair Follicle / embryology*
Heterozygote
Keratins / genetics
Mesoderm / physiology*
Mice
Mice, Knockout
Morphogenesis
Organ Culture Techniques
Proteins / genetics
Proteins / physiology*
Receptors, Cell Surface / genetics
Receptors, Growth Factor*
Skin / cytology
Skin / embryology
Skin / metabolism
Transcription Factors / genetics
Transforming Growth Factor beta*

Substances

Bmp2 protein, mouse
Bmp4 protein, mouse
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins
Carrier Proteins
Cell Adhesion Molecules
Proteins
Receptors, Cell Surface
Receptors, Growth Factor
Transcription Factors
Transforming Growth Factor beta
noggin protein
Keratins
Bone Morphogenetic Protein Receptors