ବସପାଇରୋନ

ବସପାଇରୋନ
Clinical data
Pronunciation	/ˈbjuːspɪroʊn/ (BEW-spi-rohn)
Trade names	Buspar, Namanspin
Synonyms	MJ 9022-1
AHFS/Drugs.com	monograph
MedlinePlus	a688005
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	3.9%
Protein binding	86–95%
Metabolism	Liver (via CYP3A4)
Metabolites	5-OH-Buspirone; 6-OH-Buspirone; 8-OH-Buspirone; 1-PP
Elimination half-life	2.5 hours
Excretion	Urine: 29–63%; Feces: 18–38%
Identifiers
	IUPAC name 8-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione;
ECHA InfoCard	100.048.232
Chemical and physical data
Formula	C21H31N5O2
Molar mass	୩୮୫.୫୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CCCCN2CCN(CC2)C3=NC=CC=N3)C(CC4(CCCC4)C1)=O;
	InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2 ; Key:QWCRAEMEVRGPNT-UHFFFAOYSA-N ;
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ବସପାଇରୋନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବ୍ୟବସାୟୀକ ନାମ ବସପର, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତ ଉଦ୍‌ବେଗ ଅବ୍ୟବସ୍ଥା ବିଶେଷତଃ ସାମଗ୍ରିକ ଉଦ୍‌ବେଗ ଅବ୍ୟବସ୍ଥାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୯] ^[୧୦] ଏହାର ସ୍ୱଳ୍ପ ମିଆଦି ବ୍ୟବହାରରେ ଉପକାର ମିଳେ | ^[୧୧] ସାଇକୋସିସ ଚିକିତ୍ସାରେ ଏହା ପ୍ରଭାବଶାଳୀ ନଥିବା ଜଣାପଡ଼ିଛି | ^[୧୨] ଏହା ପାଟିରେ ଦିଆଯାଏ, ଏବଂ ଏହାର ପ୍ରଭାବ ଆରମ୍ଭ ପାଇଁ ଚାରି ସପ୍ତାହ ଲାଗିପାରେ | ^[୧୨] ^[୧୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ମୁଣ୍ଡବିନ୍ଧା, ମୁଣ୍ଡ ବୁଲାଇବା ଏବଂ ଏକାଗ୍ରତା ନିମନ୍ତେ ଅସୁବିଧା ହୁଏ | ^[୯] ^[୧୧] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହାଲୁସିନେସନ, ସେରୋଟୋନିନ୍ ସିଣ୍ଡ୍ରୋମ ଏବଂ ବାତ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୧୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ମନେହୁଏ କିନ୍ତୁ ଭଲ ଭାବରେ ଏହାର ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର କରିବା ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୧୪] ^[୧୫] ଏହା କିପରି କାମ କରେ ତାହା ସ୍ପଷ୍ଟ ନୁହେଁ କିନ୍ତୁ ଏହା ବେଞ୍ଜୋଡାଏଜେପିନ ସହିତ ଜଡିତ ନୁହେଁ | ^[୧୨]

ବସପାଇରୋନ ପ୍ରଥମେ ୧୯୬୮ ମସିହାରେ ତିଆରି ହୋଇଥିଲା ଏବଂ ୧୯୮୬ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୯] ^[୧୦] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ ସୁଦ୍ଧା ମୂଲ୍ୟ ପ୍ରାୟ ୧୦ ପାଉଣ୍ଡ ଅଟେ। ^[୧୧] ^[୧୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୩ ଡଲାର ଅଟେ। ^[୧୬] ୨୦୧୭ ମସିହାରେ ଏହାର ଦଶ ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ହୋଇଥିଲା ଓ ଯୁକ୍ତରାଷ୍ଟ୍ରର ୮୦ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା | ^[୧୭] ^[୧୮]

ଆଧାର

↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 192–. ISBN 978-1-4757-2085-3.
↑ ^୨.୦ ^୨.୧ Mahmood I, Sahajwalla C (April 1999). "Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug". Clinical Pharmacokinetics. 36 (4): 277–87. doi:10.2165/00003088-199936040-00003. PMID 10320950.
↑ Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, et al. (April 2005). "Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes". Drug Metabolism and Disposition. 33 (4): 500–7. doi:10.1124/dmd.104.000836. PMID 15640381. S2CID 10142905.
↑ Loane C, Politis M (June 2012). "Buspirone: what is it all about?". Brain Research. 1461: 111–8. doi:10.1016/j.brainres.2012.04.032. PMID 22608068.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "buspirone (Rx) - BuSpar, Buspirex, more." Medscape Reference. WebMD. Retrieved 14 November 2013.
↑ Gammans RE, Mayol RF, LaBudde JA (March 1986). "Metabolism and disposition of buspirone". The American Journal of Medicine. 80 (3B): 41–51. doi:10.1016/0002-9343(86)90331-1. PMID 3515929.
↑ Schatzberg, Alan F.; Nemeroff, Charles B. (2009). The American Psychiatric Publishing Textbook of Psychopharmacology. American Psychiatric Pub. pp. 490–. ISBN 978-1-58562-309-9.
↑ Wong H, Dockens RC, Pajor L, Yeola S, Grace JE, Stark AD, et al. (August 2007). "6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats". Drug Metabolism and Disposition. 35 (8): 1387–92. doi:10.1124/dmd.107.015768. PMID 17494642. S2CID 25558546.
↑ ^୯.୦ ^୯.୧ ^୯.୨ "Buspirone Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୧୦.୦ ^୧୦.୧ Wilson, TK; Tripp, J (January 2018). "Buspirone". StatPearls. PMID 30285372.
↑ ^୧୧.୦ ^୧୧.୧ ^୧୧.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 9780857113382.
↑ ^୧୨.୦ ^୧୨.୧ ^୧୨.୨ "Buspirone Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ Wilson, TK; Tripp, J (January 2018). "Buspirone". StatPearls. PMID 30285372.
↑ ^୧୪.୦ ^୧୪.୧ ^୧୪.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 9780857113382.
↑ "Buspirone Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Buspirone - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 192–. ISBN 978-1-4757-2085-3.

[pmid10320950-2] ୨.୦ ^୨.୧ Mahmood I, Sahajwalla C (April 1999). "Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug". Clinical Pharmacokinetics. 36 (4): 277–87. doi:10.2165/00003088-199936040-00003. PMID 10320950.

[pmid15640381-3] Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, et al. (April 2005). "Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes". Drug Metabolism and Disposition. 33 (4): 500–7. doi:10.1124/dmd.104.000836. PMID 15640381. S2CID 10142905.

[pmid22608068-4] Loane C, Politis M (June 2012). "Buspirone: what is it all about?". Brain Research. 1461: 111–8. doi:10.1016/j.brainres.2012.04.032. PMID 22608068.

[MSR-5] ୫.୦ ^୫.୧ ^୫.୨ "buspirone (Rx) - BuSpar, Buspirex, more." Medscape Reference. WebMD. Retrieved 14 November 2013.

[pmid3515929-6] Gammans RE, Mayol RF, LaBudde JA (March 1986). "Metabolism and disposition of buspirone". The American Journal of Medicine. 80 (3B): 41–51. doi:10.1016/0002-9343(86)90331-1. PMID 3515929.

[SchatzbergNemeroff2009-7] Schatzberg, Alan F.; Nemeroff, Charles B. (2009). The American Psychiatric Publishing Textbook of Psychopharmacology. American Psychiatric Pub. pp. 490–. ISBN 978-1-58562-309-9.

[pmid17494642-8] Wong H, Dockens RC, Pajor L, Yeola S, Grace JE, Stark AD, et al. (August 2007). "6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats". Drug Metabolism and Disposition. 35 (8): 1387–92. doi:10.1124/dmd.107.015768. PMID 17494642. S2CID 25558546.

[AHFS2019-9] ୯.୦ ^୯.୧ ^୯.୨ "Buspirone Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Wil2018-10] ୧୦.୦ ^୧୦.୧ Wilson, TK; Tripp, J (January 2018). "Buspirone". StatPearls. PMID 30285372.

[BNF76-11] ୧୧.୦ ^୧୧.୧ ^୧୧.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 9780857113382.

[autogen5-12] ୧୨.୦ ^୧୨.୧ ^୧୨.୨ "Buspirone Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[autogen4-13] Wilson, TK; Tripp, J (January 2018). "Buspirone". StatPearls. PMID 30285372.

[autogen2-14] ୧୪.୦ ^୧୪.୧ ^୧୪.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 9780857113382.

[Preg2019-15] "Buspirone Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[NADAC2019-16] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-17] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-18] "Buspirone - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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