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Parkinson's & Movement disorders news
Neuroscience
Key pathway leading to neurodegeneration in early stages of ALS identified
Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.
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Neuroscience
New Huntington's treatment prevents protein aggregation
Scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington's disease, an incurable, debilitating illness that causes nerve cells to break down in the ...
Nov 1, 2024
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Precision diagnostics close in on Parkinson's disease proteins in extracellular vesicles
Brain disorders like Parkinson's disease (PD) or Alzheimer's disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even ...
Nov 1, 2024
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RNA structures present a promising target for early intervention in Parkinson's disease
A team of researchers at Kumamoto University has uncovered a mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's disease.
Nov 1, 2024
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Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest
A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer's disease.
Oct 31, 2024
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Study identifies 51 amyotrophic lateral sclerosis-associated mutations that could help diagnose the disease
Using sequencing techniques, researchers associated 51 mutations in mitochondrial DNA with amyotrophic lateral sclerosis (ALS), an incurable degenerative neurological disorder that leads to muscle atrophy and paralysis. Thirteen ...
Oct 31, 2024
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Rapid horizontal eye movement can improve stability in people with Parkinson's
Rapid side-to-side eye movements can help stabilize posture, avoid falls and maintain balance for people with Parkinson's disease, just as they can for healthy people. This seemingly counterintuitive conclusion was reached ...
Oct 30, 2024
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Discovery of key mechanism in Huntington's disease could pave the way for early detection and treatment
Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington's disease. This discovery opens up the possibility of studying the disease before its clinical ...
Oct 28, 2024
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How do genes shape the structures in our brains? Study finds new links to ADHD and Parkinson's
The human brain is a marvel of complexity. It contains specialized and interconnected structures controlling our thoughts, personality and behavior.
Oct 26, 2024
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Mouse model reveals liver involvement in muscular dystrophy
A new mouse model mimicking the liver symptoms of myotonic dystrophy type 1—the most prevalent form of adult-onset muscular dystrophy—provides insight into why patients develop fatty liver disease and display hypersensitivity ...
Oct 24, 2024
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Hearing loss linked to increased Parkinson's risk in veterans
Oregon Health & Science University-led researchers have found a correlative link between hearing loss and the development of Parkinson's disease (PD). They find the risk of PD rises somewhat with the severity of hearing loss, ...
Antibiotics and antifungals may slightly affect Parkinson's risk, study finds
A Rutgers Health study has found that people who took multiple courses of penicillin antibiotics had a modestly lower risk of developing Parkinson's disease, a surprising finding that researchers say highlights the complex ...
Oct 23, 2024
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FDA approves Vyalev for advanced Parkinson's disease
The U.S. Food and Drug Administration has approved AbbVie's Vyalev (foscarbidopa and foslevodopa) for adults living with advanced Parkinson's disease (PD).
Oct 23, 2024
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$3.2 million per dose Elevidys fails to meet primary endpoint in phase 3 trial
A Phase 3 clinical trial investigating Elevidys (delandistrogene moxeparvovec), a gene therapy for Duchenne muscular dystrophy, did not achieve its primary endpoint, according to findings published in Nature Medicine. A News ...
Large-scale study of brain volume finds genetic links to Parkinson's disease and ADHD
In one of the largest-ever studies of DNA and brain volume, researchers have identified 254 genetic variants that shape key structures in the "deep brain," including those that control memory, motor skills, addictive behaviors ...
Oct 21, 2024
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Challenging current understanding, study reveals rapid release of dopamine not needed for initiating movement
The chemical messenger dopamine is an essential catalyst that fuels activities and behaviors ranging from movement to cognition and learning. However, neuroscientists have long debated whether these functions rely on rapid ...
Oct 16, 2024
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For people with Parkinson's, moving is a mental challenge as well as a physical one
It's well known that Parkinson's disease can impair a person's ability to perform movements like grabbing a coffee cup, with one side of the body often more affected. But a recent study published in Brain and Cognition by ...
Oct 16, 2024
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New study reveals promising therapy that blocks microRNAs to treat myotonic dystrophy type 1
A team of researchers has identified a promising therapy based on antimiRs to treat myotonic dystrophy type 1 (DM1), a complex genetic disorder caused by an abnormally high number of CTG repeats (a specific type of RNA sequence) ...
Oct 15, 2024
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Toxic protein may contribute to amyotrophic lateral sclerosis development
A toxic version of a certain protein may affect brain, spinal cord and skeletal muscle tissues differently, leading to the complex development and progression of amyotrophic lateral sclerosis (ALS), according to a new study ...
Oct 14, 2024
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Researchers create 'mini brains' to model Lewy body dementia and pinpoint treatments
Lewy body dementia (LBD) is a progressive neurodegenerative disease that shares traits with both Parkinson's disease and Alzheimer's disease but can be more difficult to diagnose. Symptoms can include hallucinations, movement ...
Oct 14, 2024
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Clinical trial finds multidisciplinary approach improves quality of life for movement disorder patients
A research team has published a randomized clinical trial demonstrating for the first time that a multidisciplinary approach integrating specific physiotherapy and cognitive-behavioral therapy is effective in improving the ...
Oct 11, 2024
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Scientists use stem cells to recreate a hallmark of Parkinson's disease in human neurons
Lewy bodies are a hallmark of Parkinson's disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to developing better treatments.
Oct 8, 2024
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Brain molecule reverses movement deficits of Parkinson's, offering new therapeutic target
A research team from the University of California, Irvine is the first to reveal that a molecule in the brain—ophthalmic acid—unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, ...
Oct 4, 2024
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Visual mismatch negativity identified as a mechanism of Parkinson's disease psychosis
Reduced brain activity responding to unpredicted visual changes is a marker of psychosis in Parkinson's disease and a potential therapeutic target. Researchers at the IoPPN used electroencephalography (EEG) to observe participant's ...
Oct 1, 2024
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Automatic speech recognition learns to understand people with Parkinson's disease—by listening to them
As Mark Hasegawa-Johnson combed through data from his latest project, he was pleasantly surprised to uncover a recipe for Eggs Florentine. Sifting through hundreds of hours of recorded speech will unearth a treasure or two, ...
Sep 27, 2024
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