6125 Dokumente gefunden
Expressionsprofil der Toll-like-Rezeptoren von humanen Stammzellen aus Milchzähnen
Die Pulpa, in diesem Fall von Milchzähnen, dient als Ressource von mesenchymalen Stammzellen (stem cells from human exfoliated deciduous teeth (SHED)). SHED, die besondere regenerative und entzündungsresistente Eigenschaften besitzen, kommunizieren über vielfältige Wege mit ihrer Umgebung und werden…
Compositional dynamics and functional role of the microbial communities associated with the invasive ctenophore species Mnemiopsis…
While the concept of metaorganisms has gained importance, research on host-microbiome interactions remains limited, mainly focusing on humans and a few model organisms. Expanding our understanding is especially critical in the context of invasive species like certain marine organisms, which can profoundly…
Evaluation von CD30-Expression mittels digitaler Bildanalyse im Vergleich zur konventionellen lichtmikroskopischen Bestimmung…
Die zielgerichtete Therapie mit Brentuximab Vedotin (BV) wurde für CD30-positive kutane T-Zell-Lymphome (CL) nach vorangeganger Systemtherapie zur Therapie zugelassen. Die Therapie seltener Subtypen CL ist herausfordernd und aufgrund der geringen Inzidenz mangelt es an evidenzbasierten Therapieoptionen.…
Veränderung klinischer Symptome und sensorbasierter Gang- und Gleichgewichtsparameter bei idiopathischem Parkinsonsyndrom…
Das Idiopathische Parkinson-Syndrom und die Supranukleäre Progressive Blickparese sind zwei Erkrankungen, die oft nicht einfach voneinander zu unterscheiden sind. Sensorbasierte Messmethoden bedeuten dabei einen erheblichen Vorteil. Studien haben bereits Unterschiede der beiden Gruppen in statischem…
Entwicklung eines porphyrinbasierten Tests zum Nachweis von Explosivstoffen
Der Missbrauch von einfach herzustellenden Home-Made-Explosives sowie militärischen Sprengstoffen für terroristische Zwecke stellt eine erhebliche Gefahr für die öffentliche Sicherheit dar. Somit ist es von Bedeutung, einfache, kostengünstige, schnelle und hochsensitive Nachweismethoden zu entwickeln.…
Anomaly Detection Towards Modelling with Outlier Robustness
Machine learning algorithms have evolved in numerous fields into an important enabler for today's society. Thereby, anomaly detection is one of the machine learning tasks which contributes to many application domains. Anomalies, also known as outliers, can thereby be of advantageous but also of detrimental…
Development of miniaturized bioanalytical methods for the qualitative and quantitative analysis of proteins and proteomes…
Constant technological advances in analytics enable proteomics research on an increasingly smaller scale, which inevitably requires suitable downscaling of sample preparation workflows as well. The overall goals of this thesis were to investigate and develop promising sample preparation methods for handling…
From Contact Tracing to Coordination : Autonomy for Mobile Low-Power IoT Systems
With the rapid proliferation of the Internet of Things (IoT), low-power, connected devices have become ubiquitous due to their versatility, low cost, and ease of integration into larger systems. These devices enable new applications across domains, offering decentralized and resilient solutions even…
Diversity of Type VI Secretion System Effectors in Pseudomonas aeruginosa
Pseudomonas aeruginosa bacteria live in diverse environments all around the world. Wherever they live, they are not alone. They are faced with various biotic and abiotic factors. In order to survive in such environments, P. aeruginosa can make use of several molecular mechanisms. One mechanism is the…
Director-based continuum modeling and analysis of damage mechanics and coupled micro-magneto-mechanics
Complex material behavior often involves a local material orientation that is subject to evolution over time. One example of such an orientation is the direction of magnetization in magnetic materials. To represent this behavior in a continuum model, each material point (described by a position vector)…
In vitro effects of degradable Magnesium- Lithium thin films on cells of the nervous system
Lithium (Li) is used as a medication for bipolar disorder (BD) since several decades and can potentially help with managing other neurodegenerative disorders. However, a longstanding hurdle has been the narrow therapeutic range of Li which leads to several side effects and chronic toxicity. Localized…
Eine retrospektive Auswertung der Auswirkungen der Covid-19 Pandemie auf die Behandlung oraler Malignome und odontogener…
Die Covid-19-Pandemie hat das deutsche Gesundheitswesen vor große Herausforderungen gestellt. Um das Gesundheitssystem nicht weiter zu überlasten wurde am 16. März 2020 daher ein landesweiter „Lockdown“ erlassen. Krankenhäuser sowie niedergelassenen Zahnärzte mussten sich an den Zustand des „Lockdowns“…
Uncertainty Quantification of Biodegradation Models using Surrogate Models
Magnesium and its alloys are being investigated increasingly as temporary bone implant materials due to their non-toxicity, biocompatibility, and biodegradability properties. The most challenging aspect of Mg-based implants involves adapting the degradation rate to the human body, which requires extensive…
Struktur-Funktionsbeziehungen der ATPase-Domäne von ATP4 aus Plasmodium falciparum und Toxoplasma gondii
Eines der wenigen antiparasitären Wirkstofftargets stellt die Na+ /H+ -ATPase PfATP4 dar, welche von essentieller Bedeutung für den Parasiten ist. In der vorliegenden Arbeit wurden PfATP4 sowie das Homolog aus Toxoplasma gondii mithilfe der zellfreien Proteinsynthese in hohen Ausbeuten hergestellt, jedoch…
On Algorithms for Multidimensional Packing Problems and on the Complexity of higher dimensional Knapsack
This thesis consists of two parts. In the first half we consider a range of so called online problems. In an online setting we are not given all informations of our input instance immediately. Instead we receive informations over time and algorithms have to handle not only the given instance at a specific…
Evaluation der Patientenzufriedenheit während des stationären Aufenthalts an vier verschiedenen Index-Patientengruppen
Diese Patientenzufriedenheit kann von unterschiedlichen Faktoren beeinflusst werden. Das Ziel dieser Studie war die Evaluation der Patientenzufriedenheit zum stationären Aufenthalt in der Klinik für Mund-, Kiefer- und Gesichtschirurgie des Universitätsklinikums Schleswig-Holstein, Campus Kiel bei Patienten…
Essays on Management Opposition and Unionization
This dissertation explores the dynamics of management opposition to unions and the factors influencing employees’ willingness to unionize. It comprises three essays that investigate these issues through experiments and quasi-experimental methods in Germany and the United States. Essay 1 examines hiring…
Nitrification inhibitor differentially regulates manganese and phosphorus shoot concentrations in maize : The pros and cons…
High soil pH can lead to Mn2+ and P deficiency, and crop yield losses. NH4 +-N fertilization can increase soil Mn2+ availability and shoot concentration. Nitrification inhibitors (NIs) such as DMPP, can lower rhizosphere soil pH, and improve plant P uptake and prevent P deficiency. It is unknown if it…
Towards Better Cultivating Tomorrow’s STEM Workforce : An Investigation into Participants’ Needs, Predictors of Success,…
Student science competitions, such as the German Physics Olympiad, aim to attract potentially high-achieving students and support them in developing their STEM-related potentials, ultimately fostering their contribution to the future STEM workforce. Achieving these goals requires aligning participants'…
Governing climate change adaptation at the Baltic Sea Coast
This dissertation investigates public preferences for coastal adaptation to climate change at the German Baltic Sea coast. Using choice experiments, it analyses preferences at the national level (Chapter 1), assesses the stability of these preferences during the uncertainty of the COVID-19 pandemic (Chapter…